CAS: 768-59-2; (4-Ethylphenyl)Methanol

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CAS号16331-45-6 4-乙基苯甲酰氯 | CAS号4748-78-1 4-乙基苯甲醛 | CAS号1467-05-6 4-乙基苄氯 | CAS号3609-53-8 对乙酰基苯甲酸乙酯 | CAS号619-64-7 对乙基苯甲酸 | CAS号586-89-0 4-乙酰基苯甲酸 | CAS号622-96-8 4-乙基甲苯 | CAS号1585-07-5 1-溴-4-乙基苯 | CAS号100-41-4 乙苯 | CAS号4748-78-1 4-乙基苯甲醛 | CAS号57825-30-6 1-(溴甲基)-4-乙苯 | CAS号51632-28-1 4-乙基苯基乙腈 | CAS号1829-22-7 2-碘对苯二甲酸 | CAS号2567-29-5 4-溴甲基联苯 | CAS号777-90-2 1-(butoxymethyl... | CAS号59455-96-8 2-(4-ethylpheny...

对乙基苯甲酸置于lithium Aluminium Tetrahydride体系中,用92%的收率获得产物4-乙基苄醇
参考文献:空间要求高的手性钯催化剂在活化的初级 C-H 键的位点选择性 C-H 官能化中的作用
标题:空间要求高的手性钯催化剂在活化的初级 C-H 键的位点选择性 C-H 官能化中的作用
摘要:描述了空间要求严格的四羧酸二铑催化剂通过铑卡宾诱导的 Ch 插入对 Ch 官能化的位点选择性的影响.由于竞争性空间和电子效应,已建立的四脯氨酸二铑催化芳基重氮乙酸酯反应导致二级 Ch 键的优先 Ch 官能化.空间上要求更高的四(三芳基环丙烷羧酸)二铑催化剂,例如四[(R)-(1-(联苯)-2,2-二苯基环丙烷羧酸)] [rh2(r-Bpcp)4],有利于活化伯的 Ch 官能化ch 债券.使用该催化剂实现了对包含伯苄基,烯丙基和甲氧基 Ch 键的各种简单底物的高度位点选择性和对映选择性 Ch 官能化.
DOI:10.1021/ja504797X

专利信息

专利号:US-2016115113-A1
优先权日:2014-10-28
标题 :Aerobic Oxidative Esterification of Sugar-Derived 1,4-Disubstituted Benzene for Direct Synthesis of Dimethylterephthalate
发明人：SHIRAMIZU MIKA; LATTNER JAMES R; KANDEL KAPIL
权利人:EXXONMOBIL CHEM PATENTS INC
摘要:This invention relates to a dimethylterephthalate production process comprising reacting substituted furan with ethylene under cycloaddition reaction conditions and in the presence of a cycloaddition catalyst to produce a bicyclic ether, dehydrating the bicyclic ether to produce a substituted phenyl, dissolving said substituted phenyl in methanol, and oxidizing and esterifying the substituted phenyl in the presence of an oxidative esterification catalyst to form dimethylterephthalate. Importantly, the process does not include oxidizing the substituted phenyl to form terephthalic acid.

专利号:US-8062756-B2
优先权日:2005-08-26
标题:Stepwise growth of oligomeric redox-active molecules on a surface without the use of protecting groups
发明人：BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING
权利人:BOCIAN DAVID F; LINDSEY JONATHAN S; JIAO JIEYING; REGENTS OFT THE UNIVERSITY OF CALIFORNIA; UNIV NORTH CAROLINA STATE
摘要:This invention provides a procedure for growing oligomers via a stepwise process. The oligomers can include porphyrins, which have been previously shown to be attractive candidates for molecular-based information storage. The stepwise synthesis procedure requires no protecting groups, thus eliminating protection/deprotection reactions that add complexity to the process.

专利号:US-9603951-B2
优先权日:2010-02-08
标题 :Methods and apparatus for synthesizing imaging agents, and intermediates thereof
发明人：LAZEWATSKY JOEL; DEVINE MARYBETH
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18 F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

专利号:US-2011190266-A1
优先权日:2010-02-04
标 题:5,6,6a,7,8,9-HEXAHYDRO-2H-PYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
发明人：CHU DANIEL; WANG BING
权利人:CHU DANIEL; WANG BING
摘要:Provided herein are compounds having the structure set forth in Formula (I): n n n n n n n n n n wherein the variables Y, Z, A, B, R 1 , R 2 , R 3 , R 1′ , R 2′ , R 3′ , R 4 and R 5 are as defined herein and methods of their synthesis. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.

专利号:US-8940855-B2
优先权日:2009-06-02
标题:Polymers bearing pendant pentafluorophenyl ester groups, and methods of synthesis and functionalization thereof
发明人：HEDRICK JAMES L; NELSON ALSHAKIM; SANDERS DANIEL P
权利人:IBM
摘要:A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

专利号:US-11267824-B2
优先权日:2017-08-17
标 题:Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
发明人：BOSS CHRISTOPH; BUR DANIEL; CREN SYLVAINE; KIMMERLIN THIERRY; LOTZ-JENNE CARINA; POTHIER JULIEN; TIDTEN-LUKSCH NAOMI
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed.