CAS: 82-92-8; Cyclizine

• ⚠️《化妆品禁用原料目录》
• 英文名称Cyclizine
• 中文名称苯甲嗪
• IUPAC名称1-benzhydryl-4-methylpiperazine
• 其它别名(N-Benzhydryl)(N'-methyl)diethylenediamine; 1-Diphenylmethyl-4-methylpiperazine; Compound 47-83; Cyclizine; Marezine; N-Benzhydryl-N'-methylpiperazine; N-Methyl-N'-benzhydrylpiperazine; Nautazine; Ne-Devomit; Neo-Devomit; Wellcome prepn. 47-83
• CAS编号82-92-8
• MFCD编号:MFCD00067334
• EINECS号:201-445-5
• FDA UNII编号:QRW9FCR9P2
• 分子式:C18H22N2
• 分子量:266.38
• 产品CID: 1819112
• 产品分类有机原料 → 苯类化合物 → 苯和取代衍生物

• 相似结构搜索
• InChIKey: UVKZSORBKUEBAZ-UHFFFAOYSA-N
• InChI=1S/C18H22N2/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18H,12-15H2,1H3…
• 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数3.0

物理性质

• 熔点105.5-107.5°
• 沸点399.58°C (粗估)
• 闪点159.1±12.9 °C
• 密度0.9934 (粗估)
• PSA:6.48
• LogP:2.8992
• 折射率1.5840 (估算)
• 溶解性Slightly Soluble In Water And In Ethanol (96 Per Cent).
• 外观形态白色至类白色固体
• 储存条件密封, 常温干燥保存
• 产品应用该化合物用于治疗与运动病有关的恶心和呕吐.

MSDS等安全信息

• GHS象形图
• GHS符号GHS06;
  注释: Skull and crossbones
• 危险类别急性毒性 类别3(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  生殖毒性 类别2
• 警示词Danger(危险)
• 危险描述H301 |吞咽会中毒.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H361 |怀疑对生育能力或胎儿造成损害.
• 防范说明P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P310-P321-P330-P405-P501
• 危险品标志T+
• 安全声明H303+H313+H333

欧盟法规

上下游产品

合成工艺路线路线简述

• 841-77-0 = 82-92-8
  反应条件:1.1 Catalysts: Triphenylphosphine,Di-μ-Chlorobis[(1,2,5,6-η)-1,5-Cyclooctadiene]Diiridium Solvents: 2,2,2-Trifluoroethanol; 20 Min,Rt1.2 Reagents: Hydrogen Solvents: 2,2,2-Trifluoroethanol; 24 H,20 Atm,Rt
  标题:Practical N-Alkylation Via Homogeneous Iridium-Catalyzed Direct Reductive Amination
  作者:Wang,Jing; Et Al
  参考文献:Science China: Chemistry 日期:2023 卷标:66(2) 页码:518-525]
  
  109-01-3 + 90-99-3 = 82-92-8
  反应条件:1.1 45 Min,100 °C
  标题:Continuous-Flow Multistep Synthesis Of Cinnarizine,Cyclizine,And A Buclizine Derivative From Bulk Alcohols
  作者:Borukhova,Svetlana; Et Al
  参考文献:Chemsuschem 日期:2016 卷标:9(1) 页码:67-74]
  
  109-01-3 + 90-99-3 = 82-92-8
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 10 Min,Rt1.2 Solvents: Dimethylformamide; Rt; 10 H,80 °C
  标题:Synthesis And Pharmacological Evaluation Of 1-Benzhydryl Piperazine Derivatives
  作者:Thakran,Atul Kumar; Et Al
  参考文献:International Journal Of Pharmaceutical Sciences And Research 日期:2012 卷标:3(1) 页码:213-217]
  
  91-00-9 = 82-92-8
  反应条件:1.1 Catalysts: Tributylphosphine,Ruthenium Trichloride Solvents: 1,4-Dioxane
  标题:Ruthenium Complex Catalyzed N-Heterocyclization. Syntheses Of N-Substituted Piperidines,Morpholines,And Piperazines From Amines And 1,5-Diols
  作者:Tsuji,Yasushi; Et Al
  参考文献:Journal Of Organic Chemistry 日期:1985 卷标:50(9) 页码:1365-70]
  
  100-52-7 = 82-92-8
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 118 H,Reflux1.2 Reagents: Water,Ammonium Chloride2.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 210 H,Reflux2.2 Solvents: Acetonitrile; 280 H,Reflux
  标题:Synthesis And Antiinflammatory Effects Of New Piperazine And Ethanolamine Derivatives Of H1-Antihistaminic Drugs
  作者:Ahmadi,Abbas; Et Al
  参考文献:Mini-Reviews In Medicinal Chemistry 日期:2012 卷标:12(12) 页码:1282-1292]
  
  109-01-3 + 100-52-7 = 82-92-8
  反应条件:1.1 Reagents: Potassium Carbonate,Sodium Sulfate; 0 °C; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Bis(2,3,4,5,6-Pentafluorophenyl)Zinc Solvents: Toluene; 1 H,Rt2.2 Reagents: Methanol
  标题:Atom-Efficient Transition-Metal-Free Arylation Of N,O-Acetals Using Diarylzinc Reagents Through Zn/zn Cooperativity
  作者:Borys,Andryj M.; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2021 卷标:57(71) 页码:8905-8908]
  
  = 82-92-8
  反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol; 0 °C -> Rt; Overnight,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Rt2.1 Catalysts: Ruthenium(1+),[2-[[bis(1,1-Dimethylethyl)Phosphino-Kp]Methyl]Pyridine-Kn]Chloro...; Rt -> 130 °C; 72 H,130 °C
  标题:Synthesis Of 1,4-Diazacycles By Hydrogen Borrowing
  作者:Nalikezhathu,Anju; Et Al
  参考文献:Organic Letters 日期:2023 卷标:25(10) 页码:1754-1759]
  
  591-51-5 = 82-92-8
  反应条件:1.1 Reagents: Zinc Chloride Solvents: Diethyl Ether; -78 °C; -78 °C -> Rt; Overnight,Rt2.1 Reagents: Bis(2,3,4,5,6-Pentafluorophenyl)Zinc Solvents: Toluene; 1 H,Rt2.2 Reagents: Methanol
  标题:Atom-Efficient Transition-Metal-Free Arylation Of N,O-Acetals Using Diarylzinc Reagents Through Zn/zn Cooperativity
  作者:Borys,Andryj M.; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2021 卷标:57(71) 页码:8905-8908]
  
  91-01-0 = 82-92-8
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 0 - 5 °C; 4 - 6 H,0 - 5 °C2.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 10 Min,Rt2.2 Solvents: Dimethylformamide; Rt; 10 H,80 °C
  标题:Synthesis And Pharmacological Evaluation Of 1-Benzhydryl Piperazine Derivatives
  作者:Thakran,Atul Kumar; Et Al
  参考文献:International Journal Of Pharmaceutical Sciences And Research 日期:2012 卷标:3(1) 页码:213-217]
  
  119-61-9 + 109-81-9 = 82-92-8
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 48 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; 10 Min,Basified2.1 Reagents: Sodium Borohydride Solvents: Methanol; 0 °C -> Rt; Overnight,Rt2.2 Reagents: Sodium Hydroxide Solvents: Water; Rt3.1 Catalysts: Ruthenium(1+),[2-[[bis(1,1-Dimethylethyl)Phosphino-Kp]Methyl]Pyridine-Kn]Chloro...; Rt -> 130 °C; 72 H,130 °C
  标题:Synthesis Of 1,4-Diazacycles By Hydrogen Borrowing
  作者:Nalikezhathu,Anju; Et Al
  参考文献:Organic Letters 日期:2023 卷标:25(10) 页码:1754-1759]
  
  841-77-0 = 82-92-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Catalysts: [2-[(Amino-Kn)Diphenylmethyl]Phenyl-Kc]Chloro[(1,2,3,4,5-η)-1,2,3,4,5-Pentamethy... Solvents: Methanol; 5 Min,24 °C; 2 H,110 °C
  标题:Scalable Synthesis Of Antihistamines And Sensipar Via Intensified Hydrogen Borrowing Methodology
  作者:Ng,Xiao Qian; Et Al
  参考文献:Acs Sustainable Chemistry & Engineering 日期:2023 卷标:11(33) 页码:12389-12396]
  
  109-01-3 + 90-99-3 = 82-92-8
  反应条件:1.1 Solvents: Acetonitrile; 280 H,Reflux1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
  标题:Synthesis And Anti-Inflammatory Performance Of Newly Cyclizine Derivatives On Adult Male Wistar Rats
  作者:Ahmadi,Abbas; Et Al
  参考文献:Iranian Journal Of Pharmaceutical Research 日期:2012 卷标:11(4) 页码:1027-1037]
  
  107-21-1 = 82-92-8
  反应条件:1.1 Catalysts: Ruthenium(1+),[2-[[bis(1,1-Dimethylethyl)Phosphino-Kp]Methyl]Pyridine-Kn]Chloro...; Rt -> 130 °C; 72 H,130 °C
  标题:Synthesis Of 1,4-Diazacycles By Hydrogen Borrowing
  作者:Nalikezhathu,Anju; Et Al
  参考文献:Organic Letters 日期:2023 卷标:25(10) 页码:1754-1759]
  
  109-01-3 + 101-81-5 = 82-92-8
  反应条件:1.1 Reagents: Azobisisobutyronitrile,N-Bromosuccinimide Solvents: Carbon Tetrachloride; 1 H,Reflux; Reflux -> Rt1.2 Reagents: Potassium Carbonate Solvents: Acetonitrile; 2 H,Reflux
  标题:A Pd-Catalyzed Organometallic-Free Homologation Of Arylboronic Acids Enabled By Chemoselective Transmetalation
  作者:Bastick,Kane A. C.; Et Al
  参考文献:Chemrxiv 日期:2023 卷标:1 页码:1-6]
  
  109-01-3 + 101-81-5 = 82-92-8
  反应条件:1.1 Reagents: Lithium Bis(Trimethylsilyl)Amide Catalysts: Nickelate(1-),[n2,N6-Bis[2,6-Bis(1-Methylethyl)Phenyl]-2,6-Pyridinedicarboxamid... Solvents: Dimethyl Sulfoxide; 3 H,100 °C
  标题:Highly Economical And Direct Amination Of Sp3 Carbon Using Low-Cost Nickel Pincer Catalyst
  作者:Brandt,Andrew; Et Al
  参考文献:Rsc Advances 日期:2021 卷标:11(3) 页码:1862-1874]
  
  109-01-3 + 119-61-9 = 82-92-8
  反应条件:1.1 Reagents: Carbon Dioxide,Carbon Monoxide Catalysts: Dirhodium Tetraacetate Solvents: Tetrahydrofuran; 48 H,45 Bar,130 °C
  标题:Catalytic Utilization Of Converter Gas - An Industrial Waste For The Synthesis Of Pharmaceuticals
  作者:Runikhina,Sofiya A.; Et Al
  参考文献:Chemical Science 日期:2023 卷标:14(16) 页码:4346-4350]
  
  1078-58-6 = 82-92-8
  反应条件:1.1 Reagents: Bis(2,3,4,5,6-Pentafluorophenyl)Zinc Solvents: Toluene; 1 H,Rt1.2 Reagents: Methanol
  标题:Atom-Efficient Transition-Metal-Free Arylation Of N,O-Acetals Using Diarylzinc Reagents Through Zn/zn Cooperativity
  作者:Borys,Andryj M.; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2021 卷标:57(71) 页码:8905-8908]
  
  91-00-9 = 82-92-8
  反应条件:1.1 Catalysts: Iridium,Graphene (Oxide); 24 H,110 °C
  标题:Iridium/graphene Nanostructured Catalyst For The N-Alkylation Of Amines To Synthesize Nitrogen-Containing Derivatives And Heterocyclic Compounds In A Green Process
  作者:Chen,Tsun-Ren; Et Al
  参考文献:Rsc Advances 日期:2022 卷标:12(8) 页码:4760-4770]
  
  109-01-3 + 91-01-0 = 82-92-8
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 210 H,Reflux1.2 Solvents: Acetonitrile; 280 H,Reflux
  标题:Synthesis And Antiinflammatory Effects Of New Piperazine And Ethanolamine Derivatives Of H1-Antihistaminic Drugs
  作者:Ahmadi,Abbas; Et Al
  参考文献:Mini-Reviews In Medicinal Chemistry 日期:2012 卷标:12(12) 页码:1282-1292]
  
  100-52-7 = 82-92-8
  反应条件:1.1 Solvents: Tetrahydrofuran; Rt; 118 H,Reflux2.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 210 H,Reflux3.1 Solvents: Acetonitrile; 280 H,Reflux3.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
  标题:Synthesis And Anti-Inflammatory Performance Of Newly Cyclizine Derivatives On Adult Male Wistar Rats
  作者:Ahmadi,Abbas; Et Al
  参考文献:Iranian Journal Of Pharmaceutical Research 日期:2012 卷标:11(4) 页码:1027-1037]
  
  91-01-0 = 82-92-8
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 10 Min,100 °C2.1 45 Min,100 °C
  标题:Continuous-Flow Multistep Synthesis Of Cinnarizine,Cyclizine,And A Buclizine Derivative From Bulk Alcohols
  作者:Borukhova,Svetlana; Et Al
  参考文献:Chemsuschem 日期:2016 卷标:9(1) 页码:67-74]
  
  91-01-0 = 82-92-8
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 210 H,Reflux2.1 Solvents: Acetonitrile; 280 H,Reflux2.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized
  标题:Synthesis And Anti-Inflammatory Performance Of Newly Cyclizine Derivatives On Adult Male Wistar Rats
  作者:Ahmadi,Abbas; Et Al
  参考文献:Iranian Journal Of Pharmaceutical Research 日期:2012 卷标:11(4) 页码:1027-1037

海关参考信息

• 2902300000-甲苯
  2921211000-乙二胺
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管