CAS: 847502-83-4; 3,4-Difluoro-2-Methylbenzonitrile

上下游产品

1-bromo-3,4-difluoro-2-methyl-benzene copper(I) cyanide 1,2-difluoro-3-methyl-benzene

2,3-二氟甲苯置于1,1'-双(二苯基膦)二茂铁,溴,Palladium Diacetate,铁粉,Sodium Carbonate体系中,用 N-甲基吡咯烷酮,氯仿 作为反应溶剂,化学反应 27.0H,反应生成 3,4-二氟二甲基苯腈
参考文献:一种7,8-二氟-6,11-二氢-二苯并噻吩并-11-醇的制备方法
标题:一种7,8-二氟-6,11-二氢-二苯并噻吩并-11-醇的制备方法
摘要:本发明涉及一种7,8‑二氟‑6,11‑二氢‑二苯并噻吩并‑11‑醇的制备方法,具体涉及以2,3‑二氟甲苯作为原料,经过溴化反应,氰基化反应,苄溴化反应,取代反应,水解反应,环合反应,还原反应高效合成7,8‑二氟‑6,11‑二氢‑二苯并噻吩并‑11‑醇.本发明提供的巴洛沙韦中间体7,8‑二氟‑6,11‑二氢‑二苯并[b,E]噻吩并‑11‑醇的制备方法是一种高收率,低成本,环保,易操作,适宜工业化的制备方法.

专利信息

专利号:US-6593347-B2
优先权日:1998-10-30
标题 :Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
发明人：BANDARAGE UPUL K; DONG QING; FANG XINQIN; GARVEY DAVID S; MERCER GREGORY J; RICHARDSON STEWART K; SCHROEDER JOSEPH D; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.

专利号:US-7432285-B2
优先权日:1999-12-23
标 题 :Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
发明人：BANDARAGE RAMANI R; BANDARAGE UPUL K; FANG XINQIN; GARVEY DAVID S; LETTS L GORDON; SCHROEDER JOSEPH D; TAM SANG W
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.

专利号:US-2005187222-A1
优先权日:1996-02-02
标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds
发明人：GARVEY DAVID S; DE TEJADA INIGO S; GASTON RICKY D; KHANAPURE SUBHASH P; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.