2-叔丁基-4-羟基茴香醚 反应生成叔丁基对羟基茴香醚 参考文献:Process For Preparing Monoalkylethers Of Hydroquinone And Its Derivatives 标题:Process For Preparing Monoalkylethers Of Hydroquinone And Its Derivatives 摘要:一种制备羟基苯单烷基醚和取代羟基苯单烷基醚的方法,其通式为##str1##其中,R是烷基,R.Sub.1是氢或烷基,其中一种羟基苯化合物的通式为##str2##在过渡金属盐的存在下,与醇或式r-Oh反应,可以在有或没有空气或氧气的情况下进行.
专利号:US-2006128930-A1 优先权日:2004-12-03 标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants 发明人:DHAWAN ASHISH; CHOLLI ASHOK L 权利人:DHAWAN ASHISH; CHOLLI ASHOK L 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:US-7678877-B2 优先权日:2004-12-03 标题 :Process for the synthesis of polyalkylphenol antioxidants 发明人:YANG SUIZHOU; CHOLLI ASHOK L 权利人:POLNOX CORP 摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.
专利号:WO-2017046598-A1 优先权日:2015-09-16 标题:Treatment of acute inflammatory disorders 发明人:CRISANTI ANDREA; CANAVESE MIRIAM 权利人:CRISANTI ANDREA; IMP INNOVATIONS LTD 摘要:The present invention relates to a VEGF receptor agonist for use in the treatment of an acute inflammatory disorder associated with the overproduction of pro-inflammatory cytokine, administered with an agent that induces the synthesis of Nrf2. The invention also relates to pharmaceutical combinations comprising a VEGF receptor agonist and an agent that induces the synthesis of Nrf2, and kits comprising these agents. The described uses, combinations and methods may prevent or reduce the dis-regulated activation of an inflammatory response and reduce endothelial damage.
专利号:US-8129521-B2 优先权日:2005-12-14 标 题 :One pot synthesis of tetrazole derivatives of rapamycin 发明人:DHAON MADHUP K; HSIAO CHI-NUNG; PATEL SUBHASH R; BONK PETER J; CHEMBURKAR SANJAY R; CHEN YONG Y 权利人:DHAON MADHUP K; HSIAO CHI-NUNG; PATEL SUBHASH R; BONK PETER J; CHEMBURKAR SANJAY R; CHEN YONG Y; ABBOTT LAB 摘要:A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30° C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane. The solids are dissolved in acetone, treated with butylated-hydroxy toluene (BHT), and the solution concentrated. The process is repeated twice with acetone to remove solvents. At least one stabilizing agent is added, such as BHT at 0.5% before drying.
专利号:US-10017391-B2 优先权日:2015-04-23 标题:Direct polymer templating synthesis of mesoporous carbon 发明人:DAI SHENG; NELSON KIMBERLY M 权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND 摘要:The invention is directed to a method for fabricating a mesoporous carbon composite material. The method comprises providing a precursor composition and subjecting the precursor material to a curing step followed by carbonization step. The precursor composition comprises (i) a templating component comprised of a linear homopolymer material, (ii) a phenolic compound or material, (iii) a crosslinkable aldehyde component, and (iv) an acid catalyst.
专利号:EP-2354120-A1 优先权日:2003-08-20 标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof 发明人:GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE 权利人:XENOPORT INC 摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
[参考文献]: Filipa Tavares, Et Al. Cymbopogon Citratus Industrial Waste As A Potential Source Of Bioactive Compounds. J Sci Food Agric. 2015 Oct;95(13):2652-9. [参考文献]: Huihui Wang, Et Al. Vegf Enhances The Migration Of Mscs In Neural Differentiation By Regulating Focal Adhesion Turnover. J Cell Physiol. 2015 Nov;230(11):2728-42. [参考文献]: Jin-Sil Kim, Et Al. Formation And Reduction Of Carcinogenic Furan In Various Model Systems Containing Food Additives. Food Chem. 2015 Dec 15:189:108-13. [参考文献]: Kenneth J Olejar, Et Al. Influence Of Harvesting Technique And Maceration Process On Aroma And Phenolic Attributes Of Sauvignon Blanc Wine. Food Chem. 2015 Sep 15:183:181-9. [参考文献]: M Tirgar, Et Al. Suitable Coating Material For Microencapsulation Of Spray-Dried Fish Oil. J Food Sci Technol. 2015 Jul;52(7):4441-9.
合成参考文献
摘要:Lumb, J.-P.; Esguerra, K. V. N., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 590. 摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 32. 摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 53. 摘要:Zhang, J.; Liu, D.; Chen, Y., Science of Synthesis, (2021) , 371. 摘要:Selt, M.; Waldvogel, S. R., Science of Synthesis: Special Topics, (2021) 1, 262.