CAS: 121-00-6; 4-Hydroxy-3-Tert-Butylanisole

该化合物是一种具有抗氧化性特性的有机化合物,主要用作食品防腐剂,以防止脂肪和油氧化;似乎是白色的黄色晶状固体,在有机溶剂中可溶解,但水溶性有限;BHA的特点是其芬诺结构,这种结构有助于其排泄自由基和抑制氧化性降解;THA组的存在增强了其脂性,使其在各种含脂的产品中有效;BHA在特定限度内使用时被管理机构普遍承认为安全(GRAS),尽管其安全由于与高剂量或长期接触有关的潜在健康关切而成为一些争论的主题;BHA在食品中也有其使用,此外还在化妆品,药品和工业应用中发现,它有助于稳定产品免受氧化性损害.

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号15360-00-6 p-tert-butoxyanisole | CAS号88-32-4 2-叔丁基-4-羟基茴香醚 | CAS号96-76-4 2,4-二叔丁基酚 | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号75-65-0 叔丁醇 | CAS号123-31-9 对苯二酚 | CAS号732-26-3 2,4,6-三叔丁基苯酚 | CAS号15773-07-6 2-tert-butyl-4-... | CAS号77-78-1 硫酸二甲酯 | CAS号3602-55-9 叔丁基对苯醌 | CAS号2940-63-8 3-叔丁基-5-甲氧基-1,2-醌 | CAS号14078-46-7 2',5-ditert-but... | CAS号14160-38-4 3,3'-di-tert-bu... | CAS号732-26-3 2,4,6-三叔丁基苯酚 | CAS号15773-07-6 2-tert-butyl-4-... | CAS号1516-94-5 4,4'-Ethylenebi... | CAS号128-37-0 抗氧剂BHT | CAS号2607-52-5 2,6-二叔-丁基-4-亚甲基... | CAS号809-73-4 3,3',5,5'-四叔丁基-...

合成工艺路线路线简述

  • 合成目标产物 3-Tert-Butyl-4-Hydroxyanisole 主要起始原料 Dimethyl Carbonate And Tert-Butylhydroquinone
  • 9005-53-2 = 121-00-6 + 103-81-1 + 831-00-5 + 22607-11-0 + 74421-05-9 + 2219-78-5 + 219726-60-0 + 94391-24-9 + 60826-26-8 + 7443-70-1 + 51504-54-2 + 72386-20-0 + 79-31-2 + 494-99-5 + 646-07-1 + 4041-09-2 + 1131-62-0 + 432-25-7 + 56687-68-4 + 93-15-2
    反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: Molybdenum,Copper Solvents: Methanol,Water; 7 H,220 °C1.2 Reagents: Water
    标题:Cu-Mo Doped Zeolite Zsm-5 Catalyzed Conversion Of Lignin To Alkyl Phenols With High Selectivity
    作者:Singh,Sunit Kumar; Et Al
    参考文献:Catalysis Science & Technology 日期:2015 卷标:5(4) 页码:2117-2124
2-叔丁基-4-羟基茴香醚 反应生成叔丁基对羟基茴香醚
参考文献:Process For Preparing Monoalkylethers Of Hydroquinone And Its Derivatives
标题:Process For Preparing Monoalkylethers Of Hydroquinone And Its Derivatives
摘要:一种制备羟基苯单烷基醚和取代羟基苯单烷基醚的方法,其通式为##str1##其中,R是烷基,R.Sub.1是氢或烷基,其中一种羟基苯化合物的通式为##str2##在过渡金属盐的存在下,与醇或式r-Oh反应,可以在有或没有空气或氧气的情况下进行.

海关参考信息

专利信息


专利号:US-2006128930-A1
优先权日:2004-12-03
标题 :Synthesis of sterically hindered phenol based macromolecular antioxidants
发明人:DHAWAN ASHISH; CHOLLI ASHOK L
权利人:DHAWAN ASHISH; CHOLLI ASHOK L
摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes polymerizing and alkylating a phenol containing monomer represented by the following structural formula: n n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

专利号:US-7678877-B2
优先权日:2004-12-03
标题 :Process for the synthesis of polyalkylphenol antioxidants
发明人:YANG SUIZHOU; CHOLLI ASHOK L
权利人:POLNOX CORP
摘要:Disclosed is a method for the synthesis of sterically hindered polymeric antioxidants based on phenol type antioxidant monomers. The method includes partially etherifying, polymerizing and thermally rearranging a phenol containing monomer represented by the following structural formula: n nto produce a sterically hindered polymeric macromolecular antioxidant. X, R 10 and q are as defined herein. The disclosed method is a simple, direct and economical process for the synthesis of sterically hindered polymeric macromolecular antioxidants.

专利号:WO-2017046598-A1
优先权日:2015-09-16
标题:Treatment of acute inflammatory disorders
发明人:CRISANTI ANDREA; CANAVESE MIRIAM
权利人:CRISANTI ANDREA; IMP INNOVATIONS LTD
摘要:The present invention relates to a VEGF receptor agonist for use in the treatment of an acute inflammatory disorder associated with the overproduction of pro-inflammatory cytokine, administered with an agent that induces the synthesis of Nrf2. The invention also relates to pharmaceutical combinations comprising a VEGF receptor agonist and an agent that induces the synthesis of Nrf2, and kits comprising these agents. The described uses, combinations and methods may prevent or reduce the dis-regulated activation of an inflammatory response and reduce endothelial damage.

专利号:US-8129521-B2
优先权日:2005-12-14
标 题 :One pot synthesis of tetrazole derivatives of rapamycin
发明人:DHAON MADHUP K; HSIAO CHI-NUNG; PATEL SUBHASH R; BONK PETER J; CHEMBURKAR SANJAY R; CHEN YONG Y
权利人:DHAON MADHUP K; HSIAO CHI-NUNG; PATEL SUBHASH R; BONK PETER J; CHEMBURKAR SANJAY R; CHEN YONG Y; ABBOTT LAB
摘要:A single-step, one-pot process to obtain zotarolimus and other rapamycin derivatives on large scale is presented, which improves currently available synthesis schemes. In one embodiment, dried rapamycin is dissolved in isopropylacetate (IPAc). The solution is cooled, and 2,6-Lutidine is added, followed slowly adding triflic anhydride at −30° C. Salts are then removed by filtration. Tetrazole, followed by a tert-base diisopropylethylamine (DIEA) is added to the triflate solution. After incubation at room temperature, the product is concentrated and purified by a silica gel column using THF/heptane as eluant. The fractions containing the product are collected, concentrated, and purified again using an acetone/heptane column. The product containing fractions are concentrated. The product is dissolved in t-BME and precipitated with heptane. The solids are dissolved in acetone, treated with butylated-hydroxy toluene (BHT), and the solution concentrated. The process is repeated twice with acetone to remove solvents. At least one stabilizing agent is added, such as BHT at 0.5% before drying.

专利号:US-10017391-B2
优先权日:2015-04-23
标题:Direct polymer templating synthesis of mesoporous carbon
发明人:DAI SHENG; NELSON KIMBERLY M
权利人:UT BATTELLE LLC; UNIV TENNESSEE RES FOUND
摘要:The invention is directed to a method for fabricating a mesoporous carbon composite material. The method comprises providing a precursor composition and subjecting the precursor material to a curing step followed by carbonization step. The precursor composition comprises (i) a templating component comprised of a linear homopolymer material, (ii) a phenolic compound or material, (iii) a crosslinkable aldehyde component, and (iv) an acid catalyst.

专利号:EP-2354120-A1
优先权日:2003-08-20
标题 :Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人:GALLOP MARK A; YAO FENMEI; LUDWIKOW MARIA J; PHAN THU; PENG GE
权利人:XENOPORT INC
摘要:The present invention relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, pharmaceutical compositions thereof, methods of making prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof, methods of using prodrugs of (±)-4-amino-3-(4-tluorophenyl)butanoic acid and analogs thereof, and pharmaceutical compositions thereof for treating or preventing common diseases and/or disorders such as spasticity and/or acid reflux disease. The present invention also relates to acyloxyalkyl carbamate prodrugs of (±)-4-amino-3-(4-fluorophenyl)butanoic acid and analogs thereof which are suitable for oral administration and to sustained release oral dosage forms thereof.
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主要参考文献

[参考文献]: Filipa Tavares, Et Al. Cymbopogon Citratus Industrial Waste As A Potential Source Of Bioactive Compounds. J Sci Food Agric. 2015 Oct;95(13):2652-9.
[参考文献]: Huihui Wang, Et Al. Vegf Enhances The Migration Of Mscs In Neural Differentiation By Regulating Focal Adhesion Turnover. J Cell Physiol. 2015 Nov;230(11):2728-42.
[参考文献]: Jin-Sil Kim, Et Al. Formation And Reduction Of Carcinogenic Furan In Various Model Systems Containing Food Additives. Food Chem. 2015 Dec 15:189:108-13.
[参考文献]: Kenneth J Olejar, Et Al. Influence Of Harvesting Technique And Maceration Process On Aroma And Phenolic Attributes Of Sauvignon Blanc Wine. Food Chem. 2015 Sep 15:183:181-9.
[参考文献]: M Tirgar, Et Al. Suitable Coating Material For Microencapsulation Of Spray-Dried Fish Oil. J Food Sci Technol. 2015 Jul;52(7):4441-9.

合成参考文献


摘要:Lumb, J.-P.; Esguerra, K. V. N., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 590.
摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 32.
摘要:Singh, F. V.; Wirth, T., Science of Synthesis: Catalytic Oxidation in Organic Synthesis, (2017) 1, 53.
摘要:Zhang, J.; Liu, D.; Chen, Y., Science of Synthesis, (2021) , 371.
摘要:Selt, M.; Waldvogel, S. R., Science of Synthesis: Special Topics, (2021) 1, 262.
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