CAS: 124811-71-8; 4-Hydroxy-3-(Trifluoromethyl)Benzonitrile

主要参考文献

参考标题: Sphingosine Kinase Inhibitors Inhibiteurs De La Sphingosine Kinase
摘要:Sphingosine Kinases Are Enzymes That Catalyze The Biosynthesis Of Sphingosine-1-Phosphate. The Invention Provides Compounds That Are Effective For Inhibition Of Sphingosine Kinase Type 1, Sphingosine Kinase Type 2, Or Both. Certain Compounds Are Selective For Sphingosine Kinase Type 2 Relative To Sphingosine Kinase Type 1. Compounds Of The Invention Can Be Used In Treatment Of A Range Of Diseases Wherein Increasing The Level Of Sphingosine-1-Phosphate In Blood Is Medically Indicated. Diseases That Can Be Treated By Administration Of An Effective Dose Of A Compound Of The Invention Include A Neoplastic Disease That Involves Excess Vascular Growth; Macular Degeneration Or Diabetic Retinopathy; An Allergic Disease Such As Asthma, An Inflammatory Disease Of The Eye Such As Uveitis, Scleritis, Or Vitritis; An Inflammatory Disease Of The Kidney; A Fibrotic Disease; Atherosclerosis; Or Pulmonary Arterial Hypertension. A Compound Of The Invention Can Be Used To Improve The Integrity Of A Vascular Barrier In A Disease Where The Vascular Barrier Is Disrupted, Such As Cancer Or Alzheimer'S Disease.