CAS: 132539-06-1; 2-Methyl-4-(4-Methylpiperazin-1-yl)-10H-Benzo[b]Thieno[2,3-E][1,4]Diazepine

上下游产品

CAS号161696-76-0 2-甲基-4-(1-哌嗪基)-... | CAS号74-88-4 碘甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号72242-31-0 5-甲基-2-[((2-硝基苯... | CAS号109-01-3 N-甲基哌嗪 | CAS号612503-08-9 2-甲基-10H-苯并[b]噻... | CAS号138564-59-7 2-(2-硝基苯胺基)-3-氰... | CAS号873895-41-1 2-(2-aminoanili...

2-(2-硝基苯氨基)-5-甲基噻吩-3-甲酸甲酯置于palladium On Charcoal Catalyst,四氯化钛 氨体系中,用 N-甲基哌嗪,乙醇乙酸乙酯,乙酸乙酯,苯甲醚,异丙醇 用作溶剂,化学反应生成奥氮平
参考文献:2-Methyl-Thieno-Benzodiazepine
标题:2-Methyl-Thieno-Benzodiazepine
摘要:2-甲基-4-(4-甲基-1-哌嗪基)-10H-噻吩-[2,3-B][1,5]苯二氮杂环己烷,或其酸盐,具有药用性质,特别适用于治疗中枢神经系统疾病.该化合物的结构如下:##str1##

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-2003083352-A1
优先权日:2000-07-31
标 题 :Synthesis of imidazole intermediates
发明人：HELAL CHRISTOPHER J
权利人:PFIZER
摘要:The invention provides a method for synthesis of compounds of formula n n n wherein R 1 and R 19 are as defined. Compounds of formula 12 are useful as intermediates for synthesizing compounds having pharmacological activity inhibiting cdk5, cdk2, and GSK-3.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:WO-2022224090-A1
优先权日:2021-04-20
标题 :Method for the physical synthesis of metallic nanoparticles
发明人：Ã?VILA BERNAL ALBA GRACIELA; PÉREZ TABORDA JAIME ANDRÉS; LANZA BAYONA GUSTAVO ADOLFO
权利人:UNIV LOS ANDES
摘要:The present invention relates to a method for the physical synthesis of metallic nanoparticles, which comprises: (a) depositing a metallic film on a substrate of irregularly oriented salt crystal; and (b) heat-treating the metallic film deposited on the substrate until metallic nanoparticles form. This method makes it possible to obtain nanoparticles that are immobilised on a substrate and completely free of stabilising agents or surface ligands, in addition to nanoparticles in suspension or dry nanoparticles. The method also enables the production of nanoparticles having different sizes and diverse morphologies by adjusting the surface characteristics of the substrate, the characteristics of the metallic film and the thermal conditions established during the nanoparticle formation steps.

专利号:US-9315483-B2
优先权日:2007-09-13
标题 :Synthesis of deuterated catechols and benzo[D][1,3]dioxoles and derivatives thereof
发明人：JONES ANDREW D; ZELLE ROBERT E; SILVERMAN I ROBERT
权利人:CONCERT PHARMACEUTICALS INC
摘要:The present invention provides a convenient and efficient process for the synthesis of d 2 -benzo[d][1,3]dioxoles.

专利号:US-12234200-B2
优先权日:2019-04-16
标 题:Synthetic methods of preparing esketamine
发明人：CHEN CHENG YI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl.