4-溴丁酸置于三苯基膦体系中,用 甲苯 用作溶剂,化学反应 12.0H,反应生成(3-丙羧基)三苯基溴化膦 参考文献: Antibody-Drug Conjugates Comprising Glp1 Peptidomimetics And Uses Thereof[fr] Conjugués Anticorps-Médicament Comprenant Des Peptidomimétiques De Glp1 Et Leurs Utilisations 标题: Antibody-Drug Conjugates Comprising Glp1 Peptidomimetics And Uses Thereof[fr] Conjugués Anticorps-Médicament Comprenant Des Peptidomimétiques De Glp1 Et Leurs Utilisations 摘要:本文描述了蛋白质-药物结合物及其组合物,例如,用于靶向胰高血糖素样肽1受体(glp1R).在某些实施例中,提供了肽类类似物荷载和连接器-荷载以及制备它们的方法.更具体地,提供了glp1类似物,抗体-药物结合物和组合物,其中包括抗glp1R抗体和glp1类似物荷载,并提供了治疗glp1R相关疾病的方法.
专利号:US-4033949-A 优先权日:1976-04-14 标 题:Analogs of thromboxane B2 and processes for their synthesis 发明人:KELLY ROBERT C; NELSON NORMAN A 权利人:UPJOHN CO 摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.
专利号:US-3952033-A 优先权日:1975-04-23 标题 :Furan intermediates and process for synthesis of 4-hydroxycyclopetenones, prostaglandin synthesis intermediates 发明人:FLOYD JR MIDDLETON BRAWNER 权利人:AMERICAN CYANAMID CO 摘要:This disclosure describes novel 2,5-dihydro-2,5-dialkoxyfuran derivatives useful as intermediates for the preparation of the natural prostaglandins and their congeners.
专利号:US-6753449-B2 优先权日:2001-10-09 标题 :Cleavable linker for solid phase synthesis 发明人:GUO MAOJUN 权利人:ARQULE INC 摘要:Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of making and using the linkers and supports.
专利号:US-4927963-A 优先权日:1989-04-28 标题 :Novel processes for the synthesis of certain bicyclo(4.2.0)octane derivatives with valuable therapeutic properties 发明人:WALKER KEITH A M; KERTESZ DENIS J 权利人:SYNTEX INC 摘要:A process for preparing compounds represented by the formula ##STR1## wherein: X is hydrogen or lower alkoxy; n Y is hydrogen, exo-(lower alkyl) or endo-(lower alkyl); n n is an integer from 2-4; n R 2 is hydrogen or methyl; and n R 3 is linear or branched alkyl, ##STR2## --(CH 2 ) m -phenyl or --CH 2 O-phenyl; in which any phenyl may be optionally substituted with lower alkyl, lower alkoxy, trifluoromethyl, or halogen, and n a is an integer of 0, 1 or 2; n b is an integer of 3-7; n m is an integer of 0, 1 or 2, n as a mixture or separately in a sequence starting from an epoxide represented by the formula ##STR3## and processes for making the novel intermediates.
专利号:US-3682970-A 优先权日:1969-03-27 标 题:Production of unsaturated carbocyclic ketones 发明人:HENRICK CLIVE A; EDWARDS JOHN A; FRIED JOHN H 权利人:SYNTEX CORP 摘要:Preparation of Alpha , Beta -unsaturated carbocyclic ketones by reacting a methylene or methine phosphonium ylid with a delta keto carboxylic acid ester, anhydride or acyl halide. The reaction is useful for producing intermediates for synthesis of known steroids having estrogenic, progestational, or anabolic activity, for example.
专利号:EP-0257610-A2 优先权日:1986-08-25 标 题:Process and intermediates for the synthesis of the enantiomers of bicyclo(4.2.0)oct-2-en-7-one and derivatives and for the synthesis of bicyclo(4.2.0)octane derivatives
[参考文献]: Min Han, Et Al. Mitochondrial Delivery Of Doxorubicin Via Triphenylphosphine Modification For Overcoming Drug Resistance In Mda-Mb-435/dox Cells. Mol Pharm. 2014 Aug 4;11(8):2640-9.
合成参考文献
摘要:Vedantham, P.; Jiménez, M.; Hanson, P. R., Science of Synthesis, (2007) 20, 293.