专利号:US-2008319164-A1 优先权日:2007-06-20 标 题:Synthesis and application of a family of new materials resulting from the chemical cross-linking between gelatine and organic salts 发明人:BARREIROS SUSANA FILIPE; GOMES PEDRO MIGUEL VIDINHA; LOURENCO NUNO MIGUEL TORRES; CABRAL JOAQUIM MANUEL SAMPAIO; RIBEIRO INES ISABEL BAPTISTA; AFONSO CARLOS ALBERTO MATEUS 权利人:BARREIROS SUSANA FILIPE; GOMES PEDRO MIGUEL VIDINHA; LOURENCO NUNO MIGUEL TORRES; CABRAL JOAQUIM MANUEL SAMPAIO; RIBEIRO INES ISABEL BAPTISTA; AFONSO CARLOS ALBERTO MATEUS 摘要:The Scheme (I) illustrates the synthesis mechanism of the new materials. This invention involves the combination of gelatine with organic salts in the solid or liquid state. For that purpose, gelatines of several origins (animal, microbial, vegetal) can be used. n n n n n n n n n n wherein X ⊖ represents the anion of the salt and Y ⊕ represents the cation of the salt. n The invention relates also to the application of said synthesized new materials in the domains of physics, chemistry and biology, disclosing the process for the synthesis of the new materials and the use thereof as supports for biocatalysts immobilization in chemical reactions, controlled drug delivery, manufacturing of sensors/biosensors aimed at the detection of chemical species, manufacturing of conductive/semi-conductive materials, electrochemical (galvanic or electrolytic) cells or parts of cells.
专利号:US-2022161250-A1 优先权日:2019-04-01 标题:Co-deflagration synthesis of metallic, ceramic, and mixed ceramic-metallic particles 发明人:ROSEN BRIAN ASHLEY; GOZIN MICHAEL; KOMARALA ESWARA VARA PRASADARAO; FADEEV LUDMILA 权利人:TECH INNOVATION MOMENTUM FUND ISRAEL LIMITED PARTNERSHIP 摘要:A co-deflagration process for the preparation of metallic, ceramic, or mixed ceramic-metallic particles optionally impregnated within or attached to a metallic, ceramic, or mixed ceramic-metallic support material includes mixing at least two components. Each of the components can be any of a nitrogen-rich ligand or a salt thereof, a complex or coordination polymer of the nitrogen-rich ligand or salt thereof with one of the at least one metal, and a cluster of the at least one metal, and optionally an organic or inorganic oxidant, gas generator, pyrotechnic, propellant, and/or explosive.
专利号:EP-3686190-A1 优先权日:2013-07-11 标 题 :Synthesis of therapeutically active compounds
专利号:US-2008207914-A1 优先权日:2007-02-28 标题 :Bis-(1(2) h-tetrazol-5-yl)-amine monohydrate synthesis and reaction intermediate 发明人:TODA TOSHIYUKI; KOFUKUDA TORU 权利人:TOYO KASEI KOGYO CO LTD 摘要:The present invention provides Bis-(1(2)H-tetrazol-5-YL)-amine compound, and safe and inexpensive methods for producing high quality Bis-(1(2)H-tetrazol-5-YL)-amine compound. Also provided are Bis-(1(2)H-tetrazol-5-YL)-amine intermediates, and methods for their preparation. The process of preparing Bis-(1(2)H-tetrazol-5-YL)-amine intermediate substantially combines dicyanamide salt, azide salt, solvent and acid at 40-70 C temperature. The process of preparing Bis-(1(2)H-tetrazol-5-YL)-amine anhydride and/or Bis-(1(2)H-tetrazol-5-YL)-amine monohydrate comprises heating the intermediate described above at ≧75 C and adding a second acid.
专利号:US-12371404-B2 优先权日:2016-12-08 标 题 :Fused bicyclic alkylene linked imidodicarbonimidic diamides, methods for synthesis, and uses in therapy 发明人:BATCHELOR KENNETH; COBB JEFFERY E; GUDMUNDSSON KRISTJAN S; HENKE BRAD R; TAVARES FRANCIS X 权利人:NOVATARG INC 摘要:The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3-yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3-yl)alkylene]-linked imidodicarbonimidic diamides (compound of formula (I) or formula (II)), and uses therefor. The compounds of the present invention are believed to be organic cation transporter selective compounds, useful for the treatment of diseases and conditions caused by reduced activity of 5′ adenosine monophosphate-activated protein kinase (AMPK).
专利号:US-11274114-B2 优先权日:2014-08-14 标题:Modified mito-metformin compounds and methods of synthesis and use thereof 发明人:KALYANARAMN BALARAMAN; HARDY MICAEL J; LOPEZ MARCOS; OUARI OLIVIER; ZIELONKA JACEK MICHAL 权利人:MEDICAL COLLEGE WISCONSIN INC; UNIV DAIX MARSEILLE 1; UNIV IOWA STATE RES FOUND INC; AIX MARSEILLE UNIV 摘要:The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
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