CAS: 2398-37-0; 1-Bromo-3-Methoxybenzene

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CAS号591-20-8 3-溴苯酚 | CAS号616-38-6 碳酸二甲酯 | CAS号67-56-1 甲醇 | CAS号585-79-5 间溴硝基苯 | CAS号124-41-4 甲醇钠 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号591-19-5 3-溴苯胺 | CAS号870485-34-0 (3-methoxypheny... | CAS号578-57-4 邻溴苯甲醚 | CAS号106614-60-2 3-methoxy-N,N-b... | CAS号109251-88-9 (3-methoxypheny... | CAS号10540-43-9 1-fluoro-4-(3-m... | CAS号398-23-2 4,4'-二氟联苯 | CAS号6161-50-8 3,3-二甲氧基联苯 | CAS号107622-64-0 1-(3-methoxyphe... | CAS号107328-74-5 4-(3-methoxyphe... | CAS号104174-43-8 4-(3-Methoxyphe... | CAS号456-49-5 间氟苯甲醚 | CAS号100-66-3 苯甲醚

3-溴苯硼酸置于三氟化硼乙醚,Sodium Hydride体系中,用 二氯甲烷,甲基叔丁基醚,Mineral Oil 用作溶剂,化学反应 1.75H,反应生成间溴苯甲醚
参考文献:Base Mediated Synthesis Of Alkyl-Aryl Ethers From The Reaction Of Aliphatic Alcohols And Unsymmetric Diaryliodonium Salts
标题:Base Mediated Synthesis Of Alkyl-Aryl Ethers From The Reaction Of Aliphatic Alcohols And Unsymmetric Diaryliodonium Salts
摘要:The Base Mediated Coupling Of Aliphatic Alcohol Pronudeophiles With Unsymmetric Diaryliodonium Salt Electrophiles Is Described. This Metal-Free Reaction Is Operationally Simple,Proceeds At Mild Temperature,And Displays Broad Substrate Scope To Generate Industrially Important Alkyl-Aryl Ethers In Moderate To Excellent Yield. The Synthetic Utility Of These Reactions Is Demonstrated,And Aspects Of Sustainability Are Highlighted By The Use Of Unsymmetric Aryl(Mesityl)Iodonium Arylating Reagents.
Doi:10.1021/acs.Joc.5B00907

专利信息

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-8791287-B2
优先权日:2010-07-02
标 题:Process for the synthesis of tapentadol and intermediates thereof
发明人：MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA
权利人:MOTTA GIUSEPPE; VERGANI DOMENICO; BERTOLINI GIORGIO; LANDONI NICOLA; EUTICALS SPA
摘要:The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high stereoselectivity due to the presence of the benzyl group as substituent of the amino group. It was surprisingly found that this substitution shifts the keto-enol equilibrium towards the desired enantiomer and amplifies the capacity of the stereocenter present in the compound (VII) to orient the nucleophilic addition of the organometallic compound at the carbonyl towards the desired stereoisomer. This substitution thus allows obtaining a considerable increase of the yields in this step, and consequently allows significantly increasing the overall yield of the entire tapentadol synthesis process. n A further object of the present invention is constituted by the tapentadol free base in solid form, obtainable by means of the process of the invention. n Still another object of the invention is represented by the crystalline forms I and II of the tapentadol free base. n A further object of the present invention is the mixture of the crystalline forms I and II of the tapentadol free base.

专利号:US-2013296608-A1
优先权日:2011-01-27
标 题 :Novel stereospecific synthesis of (-) (2s, 3s)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol
发明人：MOHAN RAO DODDA; KRISHNAREDDY PINGILI; RAMACHANDRAREDDY PINGILI; HARITHA KIRLA; SRINIVAS KOLLURU
权利人:MOHAN RAO DODDA; KRISHNAREDDY PINGILI; RAMACHANDRAREDDY PINGILI; HARITHA KIRLA; SRINIVAS KOLLURU; SYMED LABS LTD
摘要:The present invention relates to a novel stereospecific synthesis of (−)(2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol an intermediate in the synthesis of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol.

专利号:US-6417380-B1
优先权日:1987-12-31
标 题 :Synthesis of 1,2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
摘要:Compounds having the formula: n wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., n m-phenylene), produced by reacting a compound having the formula: n with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: n are produced by reacting a compound having the formula: n with n wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula n are produced by reacting a compound of the formula n with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.

专利号:WO-2024140771-A1
优先权日:2022-12-30
标 题 :Catalyst for synthesis of polyimide, preparation method therefor and use thereof
发明人：DUAN PINGPING; HE JUNPENG; DING MINGYUE; WU HONGSHENG
权利人:BYD CO LTD
摘要:A catalyst for synthesis of polyimide. The structural formula of the catalyst is as shown in formula (I), wherein Ar 1 and Ar 2 are independently selected from a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic aryl group, and R 1 is oxygen, sulfur, a sulfone group, a sulfoxide group, a carbonyl group, a secondary amine group, an alkylene group, an alkenylene group, an alkynylene group, an alicyclic group, a heterocycloarylene group, a fused ring arylene group, or a single bond.

专利号:US-5777133-A
优先权日:1987-12-31
标 题:Synthesis of 1, 2-dioxetanes and intermediates therefor
发明人：BRONSTEIN IRENA Y; EDWARDS BROOKS
权利人:TROPIX INC
摘要:Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C 1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (eg., m-phenylene), produced by reacting a compound having the formula: ##STR2## with an R-ylating agent (e.g., R 2 SO 4 ) in the presence of an alkali metal alkoxide in a polar aprotic solvent. Also, compounds having the formula: ##STR3## are produced by reacting a compound having the formula: ##STR4## wherein X is an electronegative leaving group (e.g., a halogen anion such as chloride ion) in the presence of a Lewis base (e.g., a trialkyl-amine) dissolved in an aprotic organic solvent (e.g., benzene or toluene). Also, compounds having the formula ##STR5## are produced by reacting a compound of the formula ##STR6## with a tetra-O-acylated-O-hexopyranoside halide, then hydrolyzing off the protective acyl groups. The aforementioned compounds and procedures are useful in the synthesis of enzyme-cleavable 1,2-dioxetane ring systems that can serve as members of a binding pair employed, for example, in chemiluminescent immunoassays, DNA probe assays, and direct assays for an enzyme.