CAS: 27825-21-4; Methyl 3-Chloropyrazine-2-Carboxylate

相似化合物

89283-32-9 121246-96-6 27398-39-6

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CAS号16298-03-6 3-氨基吡嗪-2-羧酸甲酯 | CAS号27825-20-3 3-羟基-2-吡嗪甲酸甲酯 | CAS号5424-01-1 3-氨基吡嗪-2-羧酸 | CAS号20737-42-2 3-羟基-2-吡嗪甲酸 | CAS号85661-24-1 Pyrazinecarboxy... | CAS号6164-79-0 2-吡嗪羧酸甲酯 | CAS号770-00-3 METHYL2-PYRAZIN... | CAS号27398-39-6 2-氯吡嗪-3-羧酸 | CAS号2236-60-4 2-氨基-4-羟基蝶啶 | CAS号21279-62-9 3-氯吡嗪-2-酰胺 | CAS号870787-05-6 3-(三氟甲基)吡嗪-2-羧酸甲酯

2-羟基-3-吡嗪羧酸甲酯置于氯化亚砜,N,N-二甲基甲酰胺体系中,用 甲苯 用作溶剂,化学反应 3.0H,以80%的收率获得3-氯-2-吡嗪甲酸甲酯
参考文献:Methyl 3-(Triphenylphosphoranylideneamino)Pyrazine-2-Carboxylate: Synthesis,Crystal Structure And Use In Pteridin-4(3H)Ones Synthesis
标题:Methyl 3-(Triphenylphosphoranylideneamino)Pyrazine-2-Carboxylate: Synthesis,Crystal Structure And Use In Pteridin-4(3H)Ones Synthesis
摘要:标题中的亚氨基磷烷 6 是用三苯基膦-六氯乙烷-三乙胺体系,通过改进的基尔萨诺夫法,从 3-氨基吡嗪-2-羧酸甲酯 1 中制备出来的.6 的晶体结构显示了亚氨基磷烷功能(np 键).在 6 与异氰酸酯的一锅反应中得到了 2,3-二取代的蝶啶-4(3H)-酮,然后在加入醇或胺后发生杂环化反应.
Doi:10.1039/p19960000247

专利信息

专利号:US-2024335442-A1
优先权日:2021-08-02
标 题:N-acylhydrazone compounds capable of inhibiting nav1.7 and/or nav1.8, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT'ANA DANILO PEREIRA DE; GAMBA LUIS EDUARDO REINA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA; LIMA LÃ?DIA MOREIRA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO UFRJ
摘要:N-acylhydrazone compounds that are Nav 1.7 and/or Nav 1.8 inhibitors, including N-acylhydrazone compounds of Formula (I), wherein the substituents R1 to R6 are independently selected from the groups defined in the specification, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits, and which are applicable in the fields of medicinal chemistry and organic synthesis, as well as in the treatment of pain-related disorders.