CAS: 3430-14-6; 6-Methylpyridin-3-Amine

上下游产品

2-methyl-5-nitropyridine 2,2-dimethyl-3-(2-methylpyrid-5-yl)-4-oxo-4H-1,3-benzoxazine pyrographite D-Glucose N-(6-methyl-pyridin-3-yl)-acetamideN-(6-methyl-pyridin-3-yl)-acetamide 5-bromo-2-methylpyridine 3-iodo-6-methylpyridine 2‐methyl‐5‐fluoropyridine

6-甲基-3-吡啶羰基叠氮化物置于氢氧化钾体系中,化学反应生成3-氨基-6-甲基吡啶
参考文献:Graf,Journal Fur Praktische Chemie (Leipzig 1954),1932,Vol. <2> 133,P. 36,49
标题:Graf,Journal Fur Praktische Chemie (Leipzig 1954),1932,Vol. <2> 133,P. 36,49

专利信息

专利号:US-11702380-B2
优先权日:2021-03-10
标 题:Synthesis of omecamtiv mecarbil
发明人：CAILLE SEBASTIEN; MURRAY JAMES; QUASDORF KYLE; NGUYEN HANNAH; SILVA ELIPE MARIA VICTORIA; ERICSON ARI ELIZABETH
权利人:AMGEN INC
摘要:Provided herein are synthetic methods for the preparation of intermediates that are utilized in the synthesis of omecamtiv mecarbil dihydrochloride.

专利号:US-12269811-B2
优先权日:2017-06-30
标 题:Synthesis of omecamtiv mecarbil
发明人：CAILLE SEBASTIEN; QUASDORF KYLE; ROOSEN PHILIPP C; SHI XIANQING; COSBIE ANDREW; WANG FANG; WU ZUFAN; NEERGUNDA ARCHANA; QUAN BIN PETER; GUAN LIANXIU
权利人:AMGEN INC
摘要:Provided herein is a synthesis for omecamtiv mecarbil dihydrochloride hydrate and various intermediates. (1)

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:WO-2024022475-A1
优先权日:2022-07-28
标 题:A pyridinyl substituted thiohydantoin pharmaceutical intermediate and its preparation method and use
发明人：TONG YOUZHI; MENG XIANGBING; ZHANG HUIHUI; XU RUO
权利人:SUZHOU KINTOR PHARMACEUTICALS INC
摘要:The present invention belongs to the technical field of pharmaceutical synthesis technology and relates to a pyridyl-substituted thioglycolide intermediate for pharmaceutical use and its preparation method and use. In particular, the present invention discloses compounds of formula (I), which can be used to prepare thioglycolide drugs, and solves the defects of the existing process such as harsh conditions and low yields. The present invention also discloses various preparation methods of compounds of formula (I), which involve novel processes for some upstream intermediates (for example, compounds of formula (II) in the form of carboxylic acids). In addition, the present invention discloses for the first time a method for the synthesis of compounds of formula (I) to obtain thioglycolide analogues by ring closing reaction with aryl isothiocyanate.

专利号:US-2266754-A
优先权日:
标 题:Synthesis of vitamin

专利号:US-2023373955-A1
优先权日:2017-06-30
标 题:Synthesis of omecamtiv mecarbil