CAS: 406-87-1; 4,4,4-Trifluorobutanal

相似化合物

406-93-9 461-18-7 371-26-6

上下游产品

4,4,4-trifluorobutanol 3,3,3-trifluoropropyl magnesium chloride orthoformic acid triethyl ester 1,1,1-trifluoropropylene 4,4,4-trifluorobutanol 2-phenyl-4-(4,4,4-trifluorobutylidene)-5-oxazolone 2-phenyl-4-(4,4,4-trifluorobutylidene)-5-oxazolone 2-amino-5,5,5-trifluoropentanoic acid

4,4,4-三氟丁酸乙酯置于盐酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 4,4,4-三氟丁醛
参考文献:Fluoro-And Trifluoroalkyl-Containing Heterocyclic Sulfonamide Inhibitors Of Beta Amyloid Production And Derivatives Thereof
标题:Fluoro-And Trifluoroalkyl-Containing Heterocyclic Sulfonamide Inhibitors Of Beta Amyloid Production And Derivatives Thereof
摘要:提供了具有式(I)的化合物,其中t为cho,Con或c(Oh)R1R2;r1和r2为氢,可选择取代的较低烷基,Cf3,可选择取代的烯烃或可选择取代的炔烃;r3为氢或可选择取代的较低烷基;r4为(Cf3)N烷基,(Cf3)N(取代烷基),(Cf3)N烷基苯基,(Cf3)N烷基(取代苯基)或(F)N环烷基;n=1-3;r5为氢,卤素,Cf3,与y融合的双烯烃(当y为c时),或与y融合的取代双烯烃(当y为c时);w,Y和z为c,Cr6或n,其中至少有一个为c;r6为氢,卤素或可选择取代的较低烷基;x为o,S,So2或nr7;r7为氢,可选择取代的较低烷基,可选择取代的苄基或可选择取代的苯基;r8为较低烷基,Cf3或可选择取代的苯基.还描述了制备和使用这些化合物来抑制β淀粉样蛋白的产生,以及治疗阿尔茨海默病和唐氏综合征的方法.

专利信息

专利号:WO-0120995-A9
优先权日:1999-09-23
标题:Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis thereof
发明人：KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
权利人:UNIV WASHINGTON; KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY
摘要:Many Gram-negative pathogens assemble adhesive structures on their surfaces that allow them to colonize host tissues and cause disease. Novel compositions which inhibit or prevent the formation of a pilus chaperone-subunit complex are disclosed. Interfering with the function of the pili chaperone negatively affects the chaperone/usher pathway which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures and thus prevent or inhibit pilus assembly. Also provided are methods for the treatment or prevention of diseases caused by tissue-adhering pilus-forming bacteria by inhibiting the function of pilus chaperones. Also provided are pharmaceutical preparations capable of inhibiting or preventing the formation of a pilus chaperone-subunit complex. Also provided are methods of synthesizing the N-substituted amino acid compounds and compounds useful for the synthesis thereof. In particular, novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed.

专利号:US-2003096374-A1
优先权日:1999-01-27
标题:Synthesis of oligoketides

专利号:WO-2022213975-A1
优先权日:2021-04-08
标题:Compounds targeting y220c mutant of p53
发明人：LI SUJING; LI AMIN; ZHENG QIAN; Dang Chaojie; FAN XINRUI; LONG WEI; WANG YANPING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided are compounds of formula (I) which can bind to p53 mutant and restore its ability to bind DNA and activate downstream effects involved in tumor suppression. Also provided are the synthesis processes and use of the compounds.

专利号:WO-0044717-A2
优先权日:1999-01-27
标 题 :Synthesis of oligoketides

专利号:WO-0044717-A3
优先权日:1999-01-27
标题 :Synthesis of oligoketides

专利号:US-7022825-B2
优先权日:1999-01-27
标 题 :Polyketides and antibiotics
发明人：ASHLEY GARY; CHAN-KAI ISAAC C; BURLINGAME MARK A
权利人:KOSAN BIOSCIENCES INC
摘要:Facile methods for preparing diketide and triketide thioesters are disclosed. The resulting thioesters may be used as intermediates in the synthesis of desired polyketides, and may contain functional groups which ultimately reside in side chains on the resulting polyketide and thus can be used further to manipulate the polyketide so as form derivatives. The polyketides produced may also be tailored by glycosylation, hydroxylation and the like. New polyketides and their derivatives and tailored forms are thereby produced.