CAS: 4595-60-2; 2-Bromopyrimidine

相似化合物

32779-37-6 150010-20-1 124405-67-0

上下游产品

CAS号1722-12-9 2-氯嘧啶 | CAS号34671-83-5 2,2'-联嘧啶 | CAS号145208-86-2 2-(4-甲基哌嗪-1-基)嘧啶 | CAS号937593-41-4 嘧啶-2-硼酸频那醇酯 | CAS号942189-65-3 2-(6-溴吡啶-3-基)嘧啶 | CAS号37972-24-0 2-乙炔基嘧啶 | CAS号193631-86-6 2-三甲基锡乙炔嘧啶 | CAS号885702-33-0 2-溴-4-氯嘧啶 | CAS号823-09-6 2-甲硫基嘧啶 | CAS号892502-12-4 (3嘧啶-2吡啶)甲醇 | CAS号77232-38-3 4-(嘧啶-2-基)苯甲醛

2-氯嘧啶置于三甲基溴硅烷体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 4.0H,以87%的收率获得产物2-溴嘧啶
参考文献:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
标题:吡啶和其他杂环中甲硅烷基介导的卤素/卤素置换
摘要:用溴三甲基硅烷加热将 2-氯吡啶转化为 2-溴吡啶,将 2-氯-6-甲基吡啶转化为 2-溴-6-甲基吡啶.2-氯吡啶和2-溴吡啶都得到相应的碘化合物.当用原位反应生成的碘三甲基硅烷处理时.尽管 3-和 4-氯吡啶是完全惰性的,但 2,4-二氯吡啶在 2-和 4-位同时进行卤素/卤素交换.卤素置换仅在 2-位与 2,3-二氯吡啶和 2,5-二氯吡啶发生.与作为发生卤素交换的先决条件的 N-三甲基甲硅烷基吡啶鎓盐的中间体一致,2-氟吡啶和 2-氟-6-甲基吡啶和任何 2,6-二卤代吡啶都不发生反应.最后,溴/氯和碘/氯取代也可以用 2-或 4-氯喹啉,1-氯异喹啉,2-氯嘧啶,氯吡嗪和 2,3-二氯喹喔啉作为底物来完成.[在 Scifinder (R) 上]
DOI:10.1002/1099-0690(200212)2002:24<4181::Aid-Ejoc4181>3.0.Co;2-M

专利信息

专利号:WO-0061545-A1
优先权日:1999-04-14
标题 :Methods for solid phase combinatorial synthesis of integrin inhibitors
发明人：GOPALSAMY ARIAMALA; YANG HUI YU
权利人:AMERICAN HOME PROD
摘要:Compounds of the formula (I) are useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer, diabetic retinopathy, rheumatoid arthritis), restenosis (following balloon angioplasty or stent implantation), inflammation (as in rheumatoid arthritis, psoriasis), bone diseases (osteopenia induced by bone metastases, immobilization and glucocortocoid treatment, periodontal disease, hyperparathyroidism and rheumatoid arthritis), and as antiviral agents. Novel method of making compounds of formula (I) are also provided.

专利号:US-5110929-A
优先权日:1986-08-07
标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles
发明人：PARADIES HENRICH H
权利人:MEDICE CHAM PHARM FABRIK PUTTE
摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.

专利号:EP-4198027-A1
优先权日:2021-12-14
标题:Sustainable process for the synthesis of molecules with antihistamine activity in unconventional biodegradable solvents (deep eutectic solvents)
发明人：QUIVELLI ANDREA FRANCESCA; CAPRIATI VITO; PERNA FILIPPO MARIA; VITALE PAOLA; ROSSI FEDERICO VITTORIO; GARCÃ?A - Ã?LVAREZ JOAQUÃ?N
权利人:UNIV DEGLI STUDI DI BARI; UNIV OVIEDO
摘要:The present invention relates to a sustainable synthetic process for obtaining ethylenediamines molecules with antihistamine activity whose production costs are considerably reduced by employing unconventional biodegradable solvents, such as the Deep Eutectic Solvents, with considerable advantages from a point of view both of the environmental and economic impact.

专利号:US-3869456-A
优先权日:1972-03-13
标 题 :Synthesis of 5-pyrimidinecarbinols
发明人：TAYLOR HAROLD M; DAVENPORT JAMES D; HACKLER RONALD E
权利人:LILLY CO ELI
摘要:There is disclosed an improved method of synthesizing 5pyrimidinecarbinols by the addition of an alkyllithium to a mixture of 5-halopyrimidine and a ketone at a low temperature. The product compounds are useful as plant fungicides and as plant growth regulators.

专利号:US-6586187-B1
优先权日:1999-04-14
标题:Methods for solid phase combinatorial synthesis of integrin inhibitors
发明人：GOPALSAMY ARIAMALA; YANG HUI Y
权利人:WYETH CORP
摘要:Compounds of the formulaare useful in the treatment of various disorders including, but not limited to, cancer (tumor metathesis, tumorgenesis/tumor growth), angiogenesis (as in cancer, diabetic retinopathy, rheumatoid arthritis), restenosis (following balloon angioplasty or stent implantation), inflammation (as in rheumatoid arthritis, psoriasis), bone diseases (osteopenia induced by bone metastases, immobilization and glucocortocoid treatment, periodontal disease, hyperparathyroidism and rheumatoid arthritis), and as antiviral agents. Novel method of making compounds of formula I are also provided.

专利号:US-6121448-A
优先权日:1995-03-28
标题 :Pyrimidine compounds
发明人：LEWIS ROBERT ANDREWS; GOODBY JOHN WILLIAM; TOYNE KENNETH JOHNSON; HIRD MICHAEL
权利人:SECR DEFENCE BRIT
摘要:The synthesis of novel compound (I) is described: 5-bromo-2-iodopyrimidine may be used for the synthesis of a range of chemical compounds both known and novel. The synthesis of a number of novel liquid crystalline compounds is described.