CAS: 51-36-5; 3,5-Dichlorobenzoic Acid

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CAS号541-42-4 亚硝酸异丙酯 | CAS号118-92-3 邻氨基苯甲酸 | CAS号117757-68-3 3,5-二氯-4-碘苯甲酸 | CAS号1765-93-1 4-氟苯硼酸 | CAS号2789-92-6 2-氨基-3,5-二氯苯甲酸 | CAS号7758-99-8 五水硫酸铜 | CAS号108-70-3 均三氯苯 | CAS号124-38-9 二氧化碳 | CAS号650598-41-7 3,5-dichloro-4-... | CAS号25186-47-4 3,5-二氯甲苯 | CAS号554-95-0 均苯三甲酸 | CAS号3290-06-0 1,3-二氯-5-氯甲基苯 | CAS号91085-56-2 3,5-二氯苯甲酸乙酯 | CAS号23082-45-3 3,5-二氯-2-硝基苯甲酸 | CAS号82477-67-6 3-氯-5-甲氧基苯甲酸 | CAS号2905-62-6 3,5-二氯苯甲酰氯 | CAS号60211-57-6 3,5-二氯苯甲醇 | CAS号62899-78-9 3,5-二氯苯酰肼 | CAS号10203-08-4 3,5-二氯苯甲醛 | CAS号14401-72-0 3',5'-二氯苯乙酮

1,3-二氯苯置于氢氧化钾,仲丁基锂体系中,用 四氢呋喃,甲醇,环己烷,水 作为反应溶剂,化学反应 2.75H,反应生成 3,5-二氯苯甲酸
参考文献:支撑效应改变 1,3-二氯苯和 1,3-二溴苯的去质子化和功能化
标题:支撑效应改变 1,3-二氯苯和 1,3-二溴苯的去质子化和功能化
摘要:1,3-二氟苯,1,3-二氯苯和 1,3-二溴苯之间的系统比较并未揭示它们对强碱(如二异丙基氨基锂或 2,2,6,6-四甲基哌啶锂)行为的重大差异.因此,通过用合适的碱和干冰连续处理,所有 2,6-二卤代苯甲酸都可以直接获得.相比之下,(2,6-二氯苯基)-和(2,6-溴苯基)三乙基硅烷在 5-位进行去质子化(提供 4-羧基衍生物和脱保护后的 3,5-二卤代苯甲酸),而 1已知,3-二氟类似物在 4-位反应.2,4-二卤代苯甲酸被选择性地制备.从硅烷通过在 4 位溴化,相邻位置的金属化和羧化,然后脱甲硅烷基化和脱溴或 1,3-Dihalo-2-Iodobenzos 通过碱促进碘迁移到 4 位,然后碘/镁置换和随后的羧化.[在 Scifinder (R) 上]
DOI:10.1002/ejoc.200300355

专利信息

专利号:US-2002192767-A1
优先权日:1999-10-13
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli . Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:WO-02068613-A1
优先权日:2001-02-28
标题 :Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
权利人:UNIV LELAND STANFORD JUNIOR; KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. coli. Production can be enhanced in microbial organisms of polyketides and other secondary metabolites by delaying production until after exponential phase and by maintaining relatively constant nutrient levels in the medium. In addition, polyketide production can be enhanced by providing an expression system for a thioesterase II. Thus, by modifying the host organism and changing the culture conditions, synthesis of a secondary metabolite can be enhanced. The present invention also results in a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-2002045220-A1
优先权日:1999-10-13
标题:Biosynthesis of polyketide synthase substrates
发明人：KHOSLA CHAITAN; PFEIFER BLAINE
摘要:The use of enzymes which catalyze the production of starter and extender units for polyketides is described. In addition, modified loading modules are described, which can accept a variety of starting units such as substituted benzoates, and which can be used to generate substituted derivatives of natural products. These enzymes may be used to enhance the yield of polyketides that are natively produced or polyketides that are rationally designed. By using these techniques, the synthesis of a complete polyketide has been achieved in E. col. This achievement permits a host organism with desirable characteristics to be used in the production of such polyketides and to assess the results of gene shuffling.

专利号:US-6828466-B2
优先权日:2002-07-19
标题:Process for the synthesis of phenols from arenes
发明人：MALECZKA JR ROBERT E; SMITH III MILTON R; HOLMES DANIEL; SHI FENG
权利人:UNIV MICHIGAN STATE
摘要:A process to synthesize substituted phenols such as those of the general formula RR'R''Ar(OH) wherein R, R', and R'' are each independently hydrogen or any group which does not interfere in the process for synthesizing the substituted phenol including, but not limited to, halo, alkyl, alkoxy, carboxylic ester, amine, amide; and Ar is any variety of aryl or hetroaryl by means of oxidation of substituted arylboronic esters is described. In particular, a metal-catalyzed C-H activation/borylation reaction is described, which when followed by direct oxidation in a single or separate reaction vessel affords phenols without the need for any intermediate manipulations. More particularly, a process wherein Ir-catalyzed borylation of arenes using pinacolborane (HBPin) followed by oxidation of the intermediate arylboronic ester by OXONE is described.

专利号:US-5086179-A
优先权日:1988-04-27
标题 :Process for the preparation of optically pure amides
发明人：POWERS MATTHEW R; YOUSSEFYEH RAYMOND D; STUDT WILLIAM L; GOLEC FREDERICK A
权利人:RHONE POULENC RORER PHARMA
摘要:This invention is directed to certain dibenzofurancarboxamides and dibenzofurancarboxamide acids and their use as 5HT 3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D 2 receptor binding properties. Further, this invention relates to a process for the synthesis of stereoisomeric compounds having such CNS, anti-emetic and gastric prokinetic activity.