CAS: 68890-66-4; 1-Hydroxy-4-Methyl-6-(2,4,4-Trimethylpentyl)Pyridin-2(1H)-One 2-Aminoethanol Salt

上下游产品

CAS号504-29-0 2-氨基吡啶 | CAS号50650-75-4 4-甲基-6-(2,4,4-三...

3,3-二甲基丙烯酸甲酯置于aluminum (Iii) Chloride,盐酸羟胺体系中,用 1,4-二氧六环,二氯甲烷,醋酸异丙酯 作为反应溶剂,化学反应 26.0H,反应生成 羟吡酮
参考文献:一种羟吡酮乙胺盐的合成方法
标题:一种羟吡酮乙胺盐的合成方法
摘要:本发明公开了羟吡酮乙胺盐的合成方法,包括如下步骤:S1向容器中加入异壬酰氯,路易斯酸,3,3‑二甲基丙烯酸甲酯进行傅克酰化反应,得中间体m1;s2向溶剂中加入中间体m1,盐酸羟胺,0‑140oc下进行关环,羟胺化反应,得中间体m2;s3中间体m2与乙醇胺成盐反应得到羟吡酮乙胺盐.本发明仅仅在一个反应体系下就可以实现关环,羟胺化反应得到羟吡酮,相较于现行的采用先关环得到内酯,再羟胺化得到羟吡酮的两个反应体系,简化了羟吡酮乙胺盐的合成方法流程.且反应体系温度低,对工艺及设备要求降低,反应条件安全,操作简便,适合工业化大生产;且不需要使用浓硫酸,醋酸,碱,催化剂,安全环保,降低成本.

专利信息

专利号:US-6264962-B1
优先权日:1997-12-19
标 题:Use of cinnamic acid or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids. n The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-6660283-B2
优先权日:1997-12-19
标 题 :Use of cinnamic acid, or of at least one of its derivatives in a cosmetic composition
发明人：BRETON LIONEL; GIRERD FLORENCE; RENAULT BEATRICE
权利人:OREAL
摘要:The invention relates to the use of cinnamic acid, or of at least one of its derivatives, in a cosmetic composition as an agent for promoting the synthesis of the skin's total lipids.The invention also relates to a cosmetic composition comprising an effective amount of cinnamic acid or of at least one of its derivatives.

专利号:US-2019276389-A1
优先权日:2015-12-18
标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
发明人：WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.

专利号:US-9522192-B2
优先权日:2012-12-13
标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides
发明人：CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE
权利人:EPITECH GROUP SRL
摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

专利号:WO-2008028772-A1
优先权日:2006-09-06
标 题:Bioquinones for stimulating keratin synthesis
发明人：GIESEN MELANIE; SCHULZE ZUR WIESCHE ERIK; POPPE ELISABETH; WELSS THOMAS
权利人:HENKEL KGAA; GIESEN MELANIE; SCHULZE ZUR WIESCHE ERIK; POPPE ELISABETH; WELSS THOMAS
摘要:The present invention relates to the cosmetic use of one or more bioquinones for combating age-related changes in the hair follicles, for the promotion of keratin synthesis in the hair, and for positively influencing the structure of the hair. The invention further relates to a cosmetic method for combating age-related changes in the hair follicle, and to a method for stimulating keratin synthesis in hair.

专利号:US-2012095058-A1
优先权日:2003-12-03
标 题 :Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
发明人：HANAUSKE-ABEL H M; PALUMBO PAUL; CRACCHIOLO B M; PARK MYUNG-HEE; WOLFF EDITH; HANAUSKE AXEL-RAINER; MATHEWS MICHAEL B; SAXENA DEEPTI; HOQUE MAINUL
权利人:HANAUSKE-ABEL H M; PALUMBO PAUL; CRACCHIOLO B M; PARK MYUNG-HEE; WOLFF EDITH; HANAUSKE AXEL-RAINER; MATHEWS MICHAEL B; SAXENA DEEPTI; HOQUE MAINUL
摘要:The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome.