CAS: 1130-32-1; 3,3-Pentamethylene Glutarimide

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1075-89-4 1194-45-2 1130-32-1

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CAS号4355-11-7 1,1-环己基二乙酸 | CAS号77287-34-4 甲亚胺酸 | CAS号704-16-5 Acetamide,2-cya... | CAS号108-59-8 丙二酸二甲酯 | CAS号180-44-9 3-氮杂螺[5.5]十一烷 | CAS号99189-60-3 1,1-环已基二乙酸单酰胺(CAM) | CAS号64744-50-9 4,4-五亚甲基-2-吡咯烷酮 | CAS号1125-01-5 三氮杂螺-[5.5]-十一烷盐酸盐 | CAS号62550-93-0 3-(morpholin-4-...

1,1-环己基二乙酸置于ammonium Hydroxide,硫酸体系中,用 5,5-Dimethyl-1,3-Cyclohexadiene 用作溶剂,化学反应 7.0H,反应生成3,3-环戊烷戊二酰亚胺
参考文献:一种1,1-环己烷-二乙酸单酰胺的制备方法及其应用
标题:一种1,1-环己烷-二乙酸单酰胺的制备方法及其应用
摘要:本发明公开了一种1,1‑环己烷‑二乙酸单酰胺(Cdma)的制备方法,包括在非苯的非极性溶剂中,1,1‑环己基二乙酸酐和1,1‑环己烷‑二乙酸单酰胺铵盐进行酰胺化反应,得到1,1‑环己烷‑二乙酸单酰胺(Cdma);或者,在非苯的非极性溶剂中,1,1‑环己基二乙酸酐与氨加热回流反应,得到3,3‑环戊烷戊二酰亚胺;3,3‑环戊烷戊二酰亚胺经碱水解开环得到1,1‑环己烷‑二乙酸单酰胺(Cdma).其中,以1,1‑环己基二乙酸为起始原料,在酸催化下脱水得到1,1‑环己基二乙酸酐.

专利信息

专利号:US-6846950-B2
优先权日:2002-10-01
标题 :Process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride
发明人：FERRARI MASSIMO; GHEZZI MARCELLO; BELOTTI PAOLO
权利人:ERREGIERRE SPA
摘要:A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride (Gabapentin hydrochloride) comprising:n a) Reaction of a mixture of acetic anhydride/ammonium acetate with 1,1-cyclohexane-diacetic acid to yield 3,3-pentamethylene glutarimide; b) Treatment of 3,3-pentamethylene glutarimide with sodium hydroxide in an aqueous solution up to dissolution, dripping the solution thus obtained into a sodium hydroxide/sodium hypochlorite mixture, which is also aqueous, followed by acidification with hydrochloric acid to yield gabapentine hydrochloride.

专利号:US-7759517-B2
优先权日:2004-06-24
标 题:Process for the preparation of gabapentin
发明人：VILLA MARCO; PAIOCCHI MAURIZIO; ARRIGHI KATIUSCIA; CORCELLA FRANCESCO; CANNATA VINCENZO; SORIATO GIORGIO; VERZINI MASSIMO
权利人:ZACH SYSTEM SPA
摘要:The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of α, -diaminocarbonyl-β,β-pentamethylene glutarimide.

专利号:US-2004063997-A1
优先权日:2002-10-01
标 题:Process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride

专利号:EP-1558564-A2
优先权日:2002-10-01
标题:A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride

专利号:CA-2500400-A1
优先权日:2002-10-01
标题 :A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride

专利号:WO-2004031126-A3
优先权日:2002-10-01
标 题:A process for synthesis of 1-(aminomethyl)cyclohexane acetic acid hydrochloride