CAS: 119-32-4; 4-Methyl-3-Nitroaniline

该化合物是属于芳香胺类的类的有机化合物,其特征为甲基组和附于苯环的硝基组,具体地分别是4和3个位置;该化合物一般是黄色至橙色晶状固体,以其在水中的中中等溶解性而著称,有机溶剂中的溶解性较高;其熔点因纯度和具体条件不同而异;4-甲基乙基-3-硝基氨碱主要用于染料,色料和其他化学中间体的合成;必须谨慎处理该物质,因为它可能对健康造成危害,包括潜在的毒性和环境危害;建议采取适当的安全措施,包括使用个人防护设备,在与该化合物合作时要遵守有关其使用和处置的条例,因为该物质对人类健康和环境可能产生影响.

结构式图片

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号630410-29-6 (4-甲基-3-硝基苯基)氨基甲酸叔丁酯 | CAS号6375-16-2 N-(3-氨基-4-甲基苯基)乙酰胺

合成工艺路线路线简述

  • 合成目标产物 4-Methyl-3-Nitroaniline 主要起始原料 P-Toluidine
  • (文献来源)合成步骤主要原料 P-Toluidine
2,4-二硝基甲苯置于氢氧化钾,氢气体系中,用 异丙醇 用作溶剂,化学反应 3.0H,以78%的收率获得4-甲基-3-硝基苯胺
参考文献:钴(II)取代的六角形介孔铝磷酸盐分子筛上芳族硝基和羰基化合物的非均相催化转移加氢
标题:钴(II)取代的六角形介孔铝磷酸盐分子筛上芳族硝基和羰基化合物的非均相催化转移加氢
摘要:芳香族硝基和羰基化合物的催化转移氢化反应是使用新型的钴(II)取代的六角形介孔铝磷酸盐分子筛进行的.该催化剂显示出优异的收率和非常好的再循环能力.
Doi:10.1016/s0040-4039(02)02080-4

海关参考信息

专利信息


专利号:US-5369017-A
优先权日:1994-02-04
标题 :Process for solid phase glycopeptide synthesis
发明人:WONG CHI-HUEY; SCHUSTER MATTHIAS
权利人:SCRIPPS RESEARCH INST
摘要:A process for the synthesis of a glycopeptide using a solid phase matrix is disclosed. The matrix is compatible with aqueous and organic solvents and is comprised of a silica-based solid support to which is linked a two-part spacer group having a chain length of about 12 to about 40 methylene groups. The first part of the spacer is covalently bonded to the silica-based support and has a length of about 3 to about 10 methylene groups. The second spacer part is covalently bonded to the first part of the spacer and comprises the distal end of the two part spacer. The second part is soluble as a free molecule in each of water, dimethylformamide and dichloromethane and has a terminal amine or hydroxyl group to which the C-terminal residue of the peptide portion of the glycopeptide chain is bonded. The chain of atoms connecting the desired glycopeptide to the solid phase matrix also includes a moiety having a selectively severable bond which on cleavage of that bond separates the matrix from whatever else is bonded to that moiety.

专利号:CN-102372690-A
优先权日:2010-08-20
标 题:Intermediate for the synthesis of imatinib and its application in the synthesis of imatinib

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-4136033-A
优先权日:1969-11-07
标 题:6-hydroxypyridone-2 compounds having a cationic group in the 3-position
发明人:STEINEMANN WILLY
权利人:SANDOZ LTD
摘要:Compounds of the formula ##STR1## wherein K.sup.⊕ is a cationic group, preferably heterocyclic, n R is hydrogen or an organic radical, preferably alkyl, phenyl or acyl, n R 1 is hydrogen, hydrocarbyl, substituted hydrocarbyl, heterocyclyl, substituted heterocyclyl, amino or substituted amino, and n A.sup.⊖ is an anion, n Are useful as intermediates in the synthesis of azo dyes of the formula ##STR2## wherein D is an aromatic carbocyclic or heterocyclic diazo component radical, and n K.sup.⊕, r, r 1 and A.sup.⊖ are as defined above.

专利号:US-4243606-A
优先权日:1976-10-12
标 题 :N-Substituted anilines
发明人:BOURDAUDUCQ PAUL M C; BROUARD CLAUDE M H E; MOEREL CLAUDE L E; STIOT JEAN-PIERRE H
权利人:UGINE KUHLMANN
摘要:The present invention relates to new N-substituted anilines which correspond to the general formula: ##STR1## in which R 1 represents an alkyl radical or substituted alkyl radical, R 2 represents a hydrogen atom, an alkyl radical or substituted alkyl radical, R 3 represents a cyano, carbamoyl, carboxy or carbalkoxy radical and R 4 represents a hydrogen or halogen atom or an alkyl or alkoxy radical. These compounds are valuable intermediates for the preparation of coloring materials, especially as coupling compounds for the synthesis of azo dyes.

专利号:CN-112724055-A
优先权日:2021-01-13
标 题:A method for the synthesis of aromatic monofluoromethylthio compounds by one-pot method
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合成参考文献


摘要:Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku, Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972, -(133), 1972
摘要:F. Kieffer and P. Rumpf. Compt. Rend. 230, 1874 (1950).
摘要:Schafer, E.W. 1972. The acute oral toxicity of 369 pesticidal, pharmaceutical and other chemicals to wild birds. Toxicology and Applied Pharmacology. 21:315-330.
摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/S_schafer851.pdf
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