N-Methyl-3-Methyl-3-[(Methylamino)-3-Oxopropyl]Aminopropanamide置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 12.0H,以49%的收率获得n,N',N''-三甲基二丙撑三胺 参考文献:A New Stepwise Synthesis Of A Family Of Propylamines Derived From Diatom Silaffins And Their Activity In Silicification 标题:A New Stepwise Synthesis Of A Family Of Propylamines Derived From Diatom Silaffins And Their Activity In Silicification 摘要:介绍了一种逐步合成含有硅藻生物提取物中发现的 N-甲基丙胺片段的丙胺的新方法,并描述了它们在硅酸缩合中的活性. Doi:10.1039/b515967A
专利号:US-2013102730-A1 优先权日:2010-04-02 标 题:Polyamine-containing polymers and methods of synthesis and use 发明人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN 权利人:JOST ROBERT W; ULUDAG HASAN; BOLUK MEHMET YAMAN; ALBERTA INNOVATES TECHNOLOGY FUTURES 摘要:The present invention relates to polyamine-containing polymers and methods of their synthesis and use. The polymer may be hydroxyethylcellulose, dextran, poly(vinyl alcohol) or poly(methyl acrylate).
专利号:US-2024360105-A1 优先权日:2021-08-04 标 题 :Process for polyamide synthesis 发明人:ZHANG CHENGZHI 权利人:DESIGN THERAPEUTICS INC 摘要:The disclosure relates to synthetic methods for producing polyamides, for example pyrrole and imidazole containing polyamides of Formula (I) or (II), or a pharmaceutically acceptable salts thereof. These polyamides bind genes having expanded oligonucleotide repeat sequences, which thereby modulates transcription. The disclosure further provides methods of modulation of the transcription of such DNA, and the use of polyamides as therapeutic agents to treat diseases associated with such DNA.
专利号:US-6583280-B1 优先权日:2000-05-26 标 题 :Polyamine analogues having antiproliferative activity 发明人:SAAB-ISHMAIL NADA H 摘要:Novel compounds are chiral compounds which are conformationally restricted polyamine analogues for use in imaging and for therapeutic use in treatment of tumors. These analogues diminish the ability to aggregate DNA seen in the parent polyamines. The invention provides for synthesis of a library of analogues with fine structural modifications which retain restriction and conservation of the molecular weight of the parent polyamines.
专利号:US-2013102079-A1 优先权日:2010-04-02 标 题 :Polyamine-containing polymers and methods of synthesis and use
专利号:WO-2011120156-A1 优先权日:2010-04-02 标 题 :Polyamine-containing polymers and methods of synthesis and use
专利号:CA-2795084-A1 优先权日:2010-04-02 标 题:Polyamine-containing polymers and methods of synthesis and use
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合成参考文献
参考文献:10.1097/00005072-198201000-00005 摘要:Lyons JC, Scheithauer BW, Ginsburg WW. Gaucher's disease and glioblastoma multiforme in two siblings: a clinicopathologic study. J Neuropathol Exp Neurol. 1982 Jan;41(1):45–53. doi: 10.1097/00005072-198201000-00005.