CAS: 16588-74-2; 3,5-Bis(Trifluoromethyl)Phenylisocyanate

相似化合物

1548-13-6 327-78-6 2285-12-3

上下游产品

phosgene 3,5-Bis-(trifluoromethyl)aniline bis(trichloromethyl) carbonate 1-(3,5-Bis-trifluoromethyl-phenyl)-3-(2-hydroxy-4-methyl-phenyl)-urea 1-(3,5-Bis-trifluoromethyl-phenyl)-3-[2-hydroxy-5-(1,1,3,3-tetramethyl-butyl)-phenyl]-urea 1-(3,5-Bis-trifluoromethyl-phenyl)-3-(2-hydroxy-4,5-dimethyl-phenyl)-urea (3,5-Bis-trifluoromethyl-phenyl)-carbamic acid 5-bromo-2-(4-chloro-phenoxy)-phenyl ester

三光气,间二(三氟甲基)苯胺 以 二氯甲烷 用作溶剂,化学反应 0.75H,反应生成3,5-双(三氟甲基)苯基异氰酸酯
参考文献:Discovery Of Novel Vegfr-2 Inhibitors. Part 5: Exploration Of Diverse Hinge-Binding Fragments Via Core-Refining Approach
标题:Discovery Of Novel Vegfr-2 Inhibitors. Part 5: Exploration Of Diverse Hinge-Binding Fragments Via Core-Refining Approach
摘要:Pathological Angiogenesis Plays A Critical Role In Numerous Diseases Including Malignancy. Vegfr-2 Is The Central Regulators In Angiogenesis And Has Become A Promising Target For Anticancer Drug Design. We Have Identified A Novel Biphenyl-Aryl Urea Incorporated With Salicyladoxime (Bps-7) As Potent Vegfr-2 Inhibitor. As A Continuation To Our Previous Research,Various Aromatic-Heterocyclic Were Introduced As Hinge-Binding Fragment Via A Core-Refining Approach. Interestingly,Many Compounds Exhibited Comparable Vegfr-2 Inhibition To Sorafenib. In Particular,12E And 12O Displayed Excellent Vegfr-2 Inhibitory Activity With Ic50 Values Of 0.50 Nm And 0.79 Nm,Respectively. Several Title Compounds Showed Considerable Antiproliferative Activity Against A549 And Smmc-7721 Cells. In Addition,Molecular Docking Was Performed To Rationalize The Efficiency Of The Better Compounds. These Results Will Be Instructive For Further Inhibitor Design And Optimization. (C) 2015 Elsevier Masson Sas. All Rights Reserved.
Doi:10.1016/j.Ejmech.2015.08.045

专利信息

专利号:US-10100060-B2
优先权日:2016-06-16
标题:Asymmetric synthesis of funapide
发明人：BEN-DAVID RONEN; CHEN JIAN; CHRISTIE MICHAEL A; DIMITRI MINA GADELRAB; GERSHON GRACIELA NOEMI; HE LINLI; LANDMESSER NELSON G; LEVY DANIEL V; MIZRAHI OREL YOSEF; MUDIPALLI PARTHA S; REESE HARLAN F; SCLAFANI JOSEPH A; WANG YI
权利人:XENON PHARMACEUTICALS INC
摘要:This invention is directed to asymmetric synthesis of funapide, which is useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.

专利号:US-11479558-B2
优先权日:2019-07-09
标题 :Substituted tetrahydropyranoindoles, derivatives thereof, and their methods of synthesis and use
发明人：SCHEIDT KARL A; MASKERI MARK A
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are tetrahydropyranoindole compounds and derivatives thereof, as well as their methods of synthesis and use. The disclosed compounds may be synthesized by methods that utilize a cooperative hydrogen bond donor/Brønsted acid system. The disclosed compounds may be useful for treating a disease, disorder, or a symptom thereof in a subject in need thereof, such as pain, swelling, and joint stiffness. The disclosed compounds also may be useful for treating cell proliferative diseases and disorders such as cancer.

专利号:CN-111471171-B
优先权日:2019-01-24
标 题:A kind of aryl sulfonic acid intermediate and its preparation method, and its application for the synthesis of low temperature sensitive admixture for concrete

专利号:CN-115515998-A
优先权日:2020-05-06
标题 :Synthesis of Polyurethanes by Chain Growth Copolymerization

专利号:CN-115515998-B
优先权日:2020-05-06
标 题:Synthesis of polyurethanes by chain growth copolymerization

专利号:WO-2017218920-A1
优先权日:2016-06-16
标 题:Asymmetric synthesis of funapide