4,4-Diphenyl-1,3-Dioxane置于萘,水,Lithium体系中,化学反应生成3,3-二苯基丙醇 参考文献:Generation Of γ-Oxy-Substituted Benzylithium Derivatives By Reductive Lithiation Of 4-Phenyl-1,3-Dioxanes 标题:Generation Of γ-Oxy-Substituted Benzylithium Derivatives By Reductive Lithiation Of 4-Phenyl-1,3-Dioxanes 摘要:在四氢呋喃中,在催化量的萘的存在下,用金属锂还原裂解 1,3-二氧杂环戊烷 1A-C,然后与不同的亲电物反应,以非常好的收率合成了 3-取代-和 3,3-二取代-3-苯基-1-丙醇 4. Doi:10.1055/s-1999-3442
专利号:US-2004053999-A1 优先权日:1997-09-17 标题 :Novel compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
专利号:US-6225341-B1 优先权日:1995-02-27 标 题:Compounds and methods for synthesis and therapy 发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A 权利人:GILEAD SCIENCES INC 摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
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