CAS: 20582-55-2; Ethyl 4-Methylthiazole-5-Carboxylate

上下游产品

CAS号17309-13-6 2-疏基-4-甲基-5-噻唑羧酸乙酯 | CAS号7210-76-6 2-氨基-4-甲基噻唑-5-羧酸乙酯 | CAS号115-08-2 硫代甲酰胺 | CAS号609-15-4 2-氯乙酰乙酸乙酯 | CAS号77287-34-4 甲亚胺酸 | CAS号84911-18-2 2-溴-3-氧代丁酸乙酯 | CAS号52481-66-0 2-肼基-4-甲基噻唑-5-羧酸乙酯 | CAS号64-17-5 乙醇 | CAS号7647-01-0 盐酸 | CAS号7722-84-1 过氧化氢 | CAS号1977-06-6 (4-甲基噻唑-5-基)甲醇 | CAS号82294-70-0 4-甲基噻唑-5-甲醛 | CAS号81569-44-0 4-甲基噻唑-5-甲酸甲酯 | CAS号160844-75-7 2-(3-氰基-4-异丁氧基苯... | CAS号3944-31-8 diethyl 4,4-dim... | CAS号20485-41-0 4-甲基噻唑-5-甲酸 | CAS号760203-29-0 4-甲基-噻唑-5-羧酸酰胺 | CAS号78502-77-9 5-Thiazolecarbo... | CAS号78502-78-0 5-Thiazolecarbo...

2-氨基-4-甲基噻唑-5-甲酸乙酯置于亚硝酸异戊酯体系中,用 四氢呋喃 用作溶剂,化学反应 0.5H,反应生成4-甲基噻唑-5-甲酸乙酯
参考文献:铁催化串联氧化偶联和乙缩醛水解反应制备甲酰化苯并噻唑和异喹啉
标题:铁催化串联氧化偶联和乙缩醛水解反应制备甲酰化苯并噻唑和异喹啉
摘要:醛基是合成化学中最通用的中间体之一,并且将醛基引入杂芳烃对于分子结构的转化很重要.在这里,我们实现了苯并噻唑/莱和异喹啉的直接甲酰化.该反应具有新颖的铁催化的minisci型氧化偶联工艺,该工艺使用可商购的1,3-二氧戊环作为甲酰化试剂,然后进行乙缩醛水解而无需分离过程.该反应可以在非常温和的反应条件下进行,并且表现出宽泛的官能团耐受性.
Doi:10.1039/d1Cc00621E

专利信息

专利号:US-2008139558-A1
优先权日:2006-02-24
标题 :Quinolones useful as inducible nitric oxide synthase inhibitors
发明人：SMITH NICHOLAS D; ROPPE JEFFREY R; BONNEFOUS CELINE; PAYNE JOSEPH E; ZHUANG HUI; CHEN XIAOHONG; LINDSTROM ANDREW K; DURON SERGIO G; HASSIG CHRISTIAN A; NOBLE STEWART A
权利人:KALYPSYS INC
摘要:The present invention relates to novel quinolones of Formula I that inhibit inducible NOS synthase together with methods of synthesizing and using the compounds including methods for inhibiting or modulating nitric oxide synthesis and/or lowering nitric oxide levels in a patient by administering the compounds for the treatment of disease.

专利号:CN-114890998-B
优先权日:2022-04-06
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优先权日:2023-10-20
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优先权日:2023-10-20
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