专利号:GB-878693-A 优先权日:1958-03-21 标题:Synthesis of Ã~-pregnadiene-17 ª-, 21-diol-3, 20-dione
专利号:EP-0728471-B1 优先权日:1995-02-24 标题 :Cosmetic compositions for enhancing the collagen synthesis of the skin
专利号:US-7678380-B2 优先权日:1996-11-07 标 题 :Cosmetic treatment method for fighting against skin ageing effects 发明人:BONTE FREDERIC; DUMAS MARC; HEUSELE CATHERINE; LE BLAY JACQUES 权利人:LVMH RECH 摘要:The present invention relates to a method of cosmetic treatment for combating the effects of skin ageing and to novel cosmetic compositions which are particularly suitable for carrying it out. According to the invention, at least one agent for promoting the adhesion of the keratinocytes of the epidermal basal layer to the dermo-epidermal junction, especially to the collagen IV of said junction, such as, in particular, a divalent metal salt or complex, preferably magnesium aspartate or magnesium chloride, is used, optionally in association with a stimulant of collagen IV synthesis and/or a stimulant of collagen VII synthesis.
专利号:BR-112016022455-B1 优先权日:2014-03-31 标 题 :use of a supernatant from cultures of a strain of bacillus pumilus species, unnatural cosmetic or dermopharmaceutical composition; skin, stimulate collagen synthesis and / or hyaluronic acid synthesis, treatment of skin tightening and / or prevention of loss of skin firmness
专利号:US-2004146539-A1 优先权日:2003-01-24 标 题:Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits 发明人:GUPTA SHYAM K 摘要:I have discovered cosmetic or topical pharmaceutical compositions for external body part or organ slimming, firming, cellulite reduction, fat-reduction, and obesity control benefits that are in synergistic combination with benefits for the treatment of skin aging, skin wrinkles reduction, skin exfoliating, treatment of acne, treatment of rosacea, age-spots reduction, skin surface whitening, skin surface brightening striae distensae (stretch marks) reduction, treatment of pimples, treatment of skin infections and lesions, spider veins reduction, blood microcirculation (venous insufficiency) improvement, UVA/UVB protection of skin, and skin redness reduction. These compositions thus provide multiple combinations of skin and external body part or organ enhancement benefits that can be selective and specific for external body parts and organs such as face, chin, cheeks, arms, “love handlesâ€? in abdomen area, eye lids and eye zone, neck, breasts, thighs, and hips. These compositions include a body beneficial composition selected from certain nutraceutical, cosmetic, and pharmaceutical ingredients, a composition to promote collagen and elastin synthesis in the skin, and a cosmetically or pharmaceutically acceptable delivery ystem.
专利号:US-7427690-B2 优先权日:2004-06-05 标 题 :Multifunction “crown complexesâ€? from amino acids and peptides for skin and hair restoration 发明人:GUPTA SHYAM K 权利人:BIODERM RESEARCH 摘要:This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.
1: Qi JY, Jin YC, Wang XS, Yang LK, Lu L, Yue J, Yang F, Liu YS, Jiang YL, Song DK, Lv T, Li XB, Zhang K, Liu SB. Ruscogenin Exerts Anxiolytic-Like Effect via Microglial NF-κB/MAPKs/NLRP3 Signaling Pathways in Mouse Model of Chronic Inflammatory Pain. Phytother Res. 2024 Sep 12. doi: 10.1002/ptr.8325. Epub ahead of print. 225:114173. doi: 10.1016/j.phytochem.2024.114173. Epub 2024 Jun 6. 12(5):989. doi: 10.3390/biomedicines12050989. 4: Wang RY, Wang MG, Tang HZ, Du H, Luo Y, Li Q, Zhang XH, Fu J, Lv CZ. The Protective Effects of Ruscogenin Against Lipopolysaccharide-Induced Myocardial Injury in Septic Mice. J Cardiovasc Pharmacol. 2024 Aug 1;84(2):175-187. doi: 10.1097/FJC.0000000000001563.
合成参考文献
摘要:Huang BM, Yao CW, Bian QQ, Wang ZG, Mo JY. [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis]. Yao Xue Xue Bao. 2011 Apr;46(4):443–6.