3-氨基-4-硝基苯甲酸置于盐酸,Tin(Ll) Chloride体系中,化学反应生成 3,4-二氨基苯甲酸 参考文献:Studies In Chemotherapy. Ix. Ureylenebenzene And Cyclohexane Derivatives As Biotin Antagonists1 标题:Studies In Chemotherapy. Ix. Ureylenebenzene And Cyclohexane Derivatives As Biotin Antagonists1 摘要: DOI:10.1021/ja01218A044
专利号:US-6251689-B1 优先权日:1998-05-14 标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof 发明人:LABORDE EDGARDO; MATSUMOTO YUKIHARU 权利人:TELIK INC 摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.
专利号:WO-2020034022-A1 优先权日:2018-08-17 标题 :Synthesis of a fluorophore-class compound, compound produced and use thereof, process for producing white organic light emitting diodes and diodes produced 发明人:TEIXEIRA ALVES DUARTE LUIS GUSTAVO; SEVERO RODEMBUSCH FABIANO; GERMINO JOSÉ CARLOS; FALEREIRO BERBIGIER JÔNATAS; DIB ZAMBON ATVARS TERESA; MEIRA FALEIROS MARCELO 权利人:UNIV FEDERAL DO RIO GRANDE DO SUL UFRGS; UNICAMP 摘要:The present invention relates to the synthesis of a class of fluorophores developed by combining the salicylidene and benzazole classes, and to the compound produced and the technical use thereof in the form of a light emitting diode (WOLED). Said synthesis produces a compound which has advantageous optical and electronic properties and high potential for use in light emitting diodes. The present invention further relates to a process for producing white organic light emitting diodes (WOLEDs) as well as to the diodes produced.
专利号:WO-2021126118-A1 优先权日:2019-12-20 标 题:Synthesis of 2-(substitutedphenyl)-5-(substitutedheteroaryl)- 1h-benzimidazole derivatives and investigation of their biological effects 发明人:KAPLANCIKLI ZAFER ASIM; ÖZKAY YUSUF; ACAR ÇEVİK ULVIYE; SAÄžLIK BEGÜM NURPELIN; OSMANİYE DERYA; LEVENT SERKAN; KAYA ÇAVUÅžOÄžLU BETÜL; ATLI EKLİOÄžLU ÖZLEM; KARADUMAN ABDULLAH BURAK 权利人:ANADOLU UENIVERSITESI 摘要:The invention is related to the synthesis of 2-((5-(2-(4-Substitutedphenyl)-1H-benzo[d]imidazole-6-yl)-1,3,4-oxadiazole-2-yl)thio)-1-(4substitutedpiperazine-1-yl)-ethane-1-one derivative compounds and investigation of their biological effects. Cytotoxicity of the obtained compounds on 5 different cancer cell lines was evaluated and their selectivity indices were calculated.
专利号:US-5527824-A 优先权日:1985-07-22 标题 :Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis 发明人:SCHERRER ROBERT A 权利人:RIKER LABORATORIES INC 摘要:Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.
专利号:US-2018317484-A1 优先权日:2017-05-07 标题:Composition for inhibiting synthesis of mycotoxin without affecting the growth of the fungi 发明人:MEHTA ALKA; BOGA RAMESHBABU; P DHANAMJAYULU 权利人:VIT UNIV; BogaR Laboratories 摘要:A composition for inhibiting the growth of mycotoxins without affecting the growth of fungi is provided. The mycotoxin is an Aflatoxin and the fungus is an Aspergillus . The anti-aflatoxin composition comprises benzimidazole derivatives of Formula, n n n n n n n n n n where the A is hydrogen or C1-C6 alkyl or C6-C14 aryl; B is C1-C10 alkyl or C6-C14 aryl or oxygen, sulfur, nitrogen containing heteroaryl; C and D are hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl; E is hydrogen or nitro or cyano or carboxyl or acetamidoxime or amidoxime or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl; F is hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl, and mixture thereof with corresponding salts.
专利号:US-2010279122-A1 优先权日:2006-08-16 标题:Benzimidazole, Benzoxazole and Benzothiazole Derivatives, Optical Film Comprising them and Method of Producing thereof 发明人:NOKEL ALEXEY; LAZAREV PAVEL I 权利人:CRYSOPTIX KK 摘要:The present invention is relates to the synthesis of predominantly planar heterocyclic organic compound and the manufacture of optical films based on these compounds. Said organic compound has the general structural formula where Het is a predominantly planar heterocyclic molecular system possessing hydrophilic properties; B is a binding group; p is the number in the range from 3 to 8; S is a group providing solubility of the organic compound; m is a number in the range from 0 to 8. Said organic compound is transparent for electromagnetic radiation in the visible spectral range from 400 to 700 nm, and a solution of the compound or a salt thereof is capable of forming a substantially transparent optical layer on a substrate, with the heterocyclic molecular planes oriented predominantly parallel to the substrate surface.
[参考文献]: L A Cooper, Et Al. Differentiation And Melanin Production In Hyaline And Pigmented Strains Of Microdochium Bolleyi. Antonie Van Leeuwenhoek. 1984;50(1):53-62. [参考文献]: N Sundaraganesan, Et Al. Vibrational Spectra And Quantum Chemical Calculations Of 3,4-Diaminobenzoic Acid. Spectrochim Acta A Mol Biomol Spectrosc. 2008 Jul;70(2):376-83. [参考文献]: Osmar Calderon Sanchez, Et Al. (99M)Tc Complexes With Activated Ester Functions; Ligands Comprising A 3,4-Diamino-Benzoate Backbone. Nucl Med Biol. 2006 Apr;33(3):381-90. [参考文献]: R M Vickers, Et Al. Clinical Laboratory Differentiation Of Legionellaceae Family Members With Pigment Production And Fluorescence On Media Supplemented With Aromatic Substrates. J Clin Microbiol. 1984 May;19(5):583-7. [参考文献]: S Ram, Et Al. Synthesis And Biological Activity Of Certain Alkyl 5-(Alkoxycarbonyl)-1H-Benzimidazole-2-Carbamates And Related Derivatives: A New Class Of Potential Antineoplastic And Antifilarial Agents. J Med Chem. 1992 Feb 7;35(3):539-47.
合成参考文献
摘要:Tymoshenko, D. O., Science of Synthesis Knowledge Updates, (2012) 3, 354. 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:Compound: Benzoic acid, 3,4-diamino-, homopolymer 摘要:P.Vetesnik, J. Bielavsky and M. Vecera. Coll. Czech. Chem. Comm. 33, 1687 (1968). 摘要:P.Vetesnik, J. Bielavsky, J. Kavalek and M. Vecera. Coll. Czech. Chem. Comm. 33, 2902 (1968).