CAS: 68-12-2; N,N-Dimethylformamide

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CAS号201230-82-2 carbon monoxide | CAS号124-40-3 二甲胺 | CAS号124-38-9 二氧化碳 | CAS号64-18-6 甲酸 | CAS号3585-33-9 二甲基胺锂 | CAS号506-59-2 盐酸二甲胺 | CAS号117731-86-9 2-(2-ethenoxyet... | CAS号107-31-3 甲酸甲酯 | CAS号75-50-3 三甲胺 | CAS号50-00-0 甲醛 | CAS号1032-98-0 3-(2-benzothiaz... | CAS号106129-86-6 3-(dimethylamin... | CAS号1064678-66-5 3-溴-5-氯吡啶-4-羧醛 | CAS号10045-65-5 1-苄基-1H-咪唑-2-甲醛 | CAS号112372-07-3 呋喃并[3,2-c]吡啶-2-羧醛 | CAS号110912-15-7 3-氯-1H-吲哚-2-甲醛 | CAS号1093880-37-5 6-氯-2-氟尼古丁醛 | CAS号1079252-75-7 4-溴-3-甲酰基-1H-吲哚... | CAS号112372-05-1 呋喃并[3,2-b]吡啶-2-羧醛 | CAS号1060809-20-2 6-氯-4-氟烟醛

4-甲基噻唑 反应生成 N,N-二甲基甲酰胺
参考文献:Pyrazine Derivative And Application Thereof In Inhibiting Shp2
标题:Pyrazine Derivative And Application Thereof In Inhibiting Shp2
摘要:本发明涉及吡嗪衍生物,其在抑制shp2中的应用,以及具有化学式(I)的化合物或其药用可接受的盐,酯,异构体,溶剂合物,前药或同位素标记.化合物的化学式(I)结构如下.本发明提供的新型吡嗪衍生物具有出色的抑制shp2活性,并可用于预防和/或治疗非受体蛋白酪氨酸磷酸酶介导或依赖的疾病或紊乱.

专利信息

专利号:US-12012427-B2
优先权日:2019-10-31
标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
发明人：SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

专利号:WO-2021014395-A1
优先权日:2019-07-24
标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs
发明人：ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT
权利人:DR REDDY’S INST OF LIFE SCIENCES
摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.

专利号:US-2024409495-A1
优先权日:2021-10-20
标 题 :Process for the preparation of 2,7-dihydroxy-9-fluorenone useful for the synthesis of tilorone and its salts
发明人：JAISANKAR PARASURAMAN; DEB INDUBHUSAN; BHATTACHARJEE PINAKI
权利人:COUNCIL SCIENT IND RES
摘要:Methods involving preparation of building blocks of 2,7-dihydroxy-9-fluorenone toward the synthesis of tilorone dihydrochloride salt and other salts (bromide, iodide, fluoride, citrate, oxalate, maleate, phosphate, tartrate, triflate, trifluoroacetate, tetrafluoroborate) of tilorone, and an efficient, safe, cost effective method for the preparation of 2,7-bis-[2-(diethylamino)ethoxy]-fluorenone-9 and its various salts are developed. The methods involve oxygenation of fluorene, nitration of fluorenone, followed by reduction and diazotization toward the formation of 2,7-dihydroxy-9-fluorenone, which is the key intermediate for the formation of 2,7-bis-[2-(diethylamino)ethoxy]-9-fluorenone-dihydrochloride (Tilorone dihydrochloride) and other tilorone salts. The synthesis method has relatively simple operation, mild reaction conditions, high yield, and simple process with yields of 80-97%. Subsequent product purification of this method uses filtration and crystallization methods, avoiding the existing methods of column chromatography. Therefore, the research of its synthetic method being with a wide range of applications from the drug development and material synthesis point of view.

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:WO-2024193201-A1
优先权日:2023-03-22
标题:Machine learning-based multi-objective optimization method for route for synthesis of mofs
发明人：WANG GE; LIN JING; GAO HONGYI; LIU ZHIMENG; BAN TAO; LI TIAN; ZHOU SHENGLAN
权利人:UNIV BEIJING SCIENCE & TECHNOLOGY
摘要:A machine learning-based multi-objective optimization method for a route for synthesis of MOFs. The method comprises: collecting a synthesis condition for preparing Ce-UiO-66, evaluating defect content and thermal stability by means of a thermogravimetric analysis curve, and using same as an initial data set; randomly dividing the data set into a training set and a testing set, respectively modeling each performance of the Ce-UiO-66 using eight algorithms, and screening representative models used for for prediction of each performance; calculating an objective achievement probability (PA) value of each performance in a synthesis space, and expanding same to a multi-objective evaluation factor; preparing a Ce-UiO-66 material; performing a characterization test on the obtained material, and if test data does not satisfy a requirement, updating the data set and the proxy model. Being based on reliable experimental data and machine learning has the advantages of low cost, short period, and the like for optimization of catalysis and stability of MOFs, and the method can be expanded to the design of synthesis routes for other materials.

专利号:WO-2023030277-A1
优先权日:2021-08-30
标 题:Method for fully liquid-phase synthesis of grnh nonapeptide amide analog
发明人：SUN PENGCHENG; PAN JING; WU JUNYONG; TANG YONGBO; Du Yixiong; GUO LIN
权利人:HUNAN MICRO PEPTIDE BIOMEDICAL CO LTD
摘要:Provided is a method for fully liquid-phase synthesis of a GRnH nonapeptide amide analog, which belongs to the technical field of medicine synthesis. The method comprises respectively synthesizing a 'Trp-Ser-Tyr' fragment, an 'R-Leu' fragment, a 'Pyr-His' fragment and 'Arg-Pro-Hunan T', wherein, R = D-Ala (alarelin), D-Leu (leuprorelin), D-Trp (deslorelin) and D-His (histrelin), and obtaining the GRnH nonapeptide amide analog with high yield and high purity by means of a '3 +2 +2 +2' fragment condensation method. The synthesis method is environmentally friendly, mild, and free of any highly toxic and poisonable reagents. The cost is greatly reduced and the synthesis method is very suitable for large-scale production.