CAS: 79271-56-0; Triethylsilyl Trifluoromethanesulfonate

相似化合物

79271-56-0 116507-88-1 126889-55-2

上下游产品

CAS号994-30-9 三乙基氯硅烷 | CAS号1493-13-6 三氟甲烷磺酸 | CAS号617-86-7 三乙基硅烷 | CAS号1061307-56-9 R-Α,Α-双(3,5-二三氟... | CAS号14629-52-8 Triethylpentoxy... | CAS号617-86-7 三乙基硅烷 | CAS号23273-02-1 H2B(μ-H)(μ-NMe2)BH2 | CAS号79430-76-5 [Me2NH2]OTf | CAS号1631-33-0 三乙基(硅烷-d) | CAS号91-01-0 二苯甲醇 | CAS号20098-55-9 2-diazonio-1-et... | CAS号80239-20-9 2,4-dimethylpen... | CAS号872839-39-9 triethyl(hept-6...

三乙基硅烷,三氟甲磺酸 以 氘代乙腈 作为反应溶剂,化学反应生成 三乙基硅基三氟甲磺酸酯
参考文献:二亚胺亲核加合物是稳定且方便的强路易斯酸**
标题:二亚胺亲核加合物是稳定且方便的强路易斯酸**
摘要:二亚胺亲核加合物是一种方便的路易斯酸,可以满足某些超酸性的要求,通过与稳定的吡啶供体配位来合成.即使在从 P=o 键中提取半当量氧化物时,也观测到了有利的提取动力学.我们的初步结果结合价格和安全性考虑表明该加合物是优异的酰化试剂.
DOI:10.1002/chem.202302089

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.

专利号:WO-2024182268-A1
优先权日:2023-02-27
标 题 :Liquid phase peptide support synthesis of peptides and peptidomimetics
发明人：HAN AMY
权利人:REGENERON PHARMA
摘要:The present invention provides compounds useful as support for liquid phase organic synthesis e.g., liquid phase organic synthesis of peptides and peptidomimetics. In one aspect, the present invention provides a compound having a structure of Formula (I) where R1, R2, R3, m, and n are as described herein and methods of making and using same.

专利号:US-6579725-B1
优先权日:1999-03-05
标题 :Linkers for synthesis of oligosaccharides on solid supports
发明人：SEEBERGER PETER H; ANDRADE RODRIGO B
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present invention relates to versatile linkers for tethering a molecule to a solid support, e.g., for tethering a monomer, oligomer or polymer to a solid support, which are stable to a wide range of reaction conditions, but can be cleaved under well-defined conditions, thereby liberating the molecule from the solid support. Preferably, the linkers are used to tether to the solid support unprotected, partially-protected or fully-protected monosaccharides or oligosaccharides, or unprotected, partially-protected or fully-protected glycoconjugates. The linkers of the present invention may be used to tether to solid supports building blocks useful in the assembly of libraries of other types of small molecules. The present invention also relates to a molecule or plurality of molecules tethered to the solid support via a linker or linkers of the present invention. The present invention also relates to processes for synthesizing molecules, e.g., monomers, oligomers or polymers, on a solid support, wherein a starting material in the synthesis of the molecule, intermediates in the synthesis of the molecule, and the molecule itself are tethered to the solid support during the process via one of the linkers of the present invention. In certain processes of the present invention, the molecule is liberated from the solid support by cleavage of the linker of the present invention.

专利号:US-6350878-B1
优先权日:1998-05-18
标 题 :Intermediates for the synthesis of epothilones and methods for their preparation
发明人：ALTMANN KARL-HEINZ; BAUER ARMIN; SCHINZER DIETER
权利人:NOVARTIS AG
摘要:The invention relates to a method of synthesis for a compound of formula (I),wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.