CAS: 90734-71-7; 3-Acetyl-6-Chloroimidazo[1,2-B]Pyridazine

该化合物是一个异环化合物,其内有一异丁二烯[1,2,b] pyridazine核心,其六方为氯替代体,三方为乙酰基,该结构具有重要的再活动性和多功能性,使它成为制药和农用化学合成中有价值的中间体.氯组增强了电子生物替代潜力,而克酮功能允许进一步衍生,如凝聚或减少反应.其硬性引信环系系统有助于稳定性和潜在生物活动,在发现药物时经常被利用,以针对动酶抑制剂或其他与生物相关的途径.该化合物的界定精密合成路线和高纯度适合于需要精确分子修改的研究规模应用.

结构式图片

相似化合物

154578-26-4 1208084-53-0 137384-48-6

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C&L通报

上下游产品

CAS号78-95-5 氯丙酮 | CAS号35053-55-5 [2-(6-氯-3-吡嗪)-2... | CAS号598-31-2 溴丙酮 | CAS号453548-65-7 1-咪唑并[1,2-b]哒嗪-3-基乙酮

合成工艺路线路线简述

  • 35053-55-5 = 90734-71-7 [标题:Reaction Conditions
    标题:A New Approach For The Synthesis Of Fused Imidazoles: The Synthesis Of 3-Acyl-Substituted Imidazo[1,2-X]Azines
    作者:Podergajs,Simona; Stanovnik,Branko; Tisler,Miha
    参考文献:Synthesis 日期:1984 卷标:(3) 页码:263-5
溴丙酮,(Z)-N'-(6-Chloropyridazin-3-yl)-N,N-Dimethylformimidamide置于sodium Iodide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,以0.7 G的收率获得产物3-乙酰基-6-氯咪唑并[1,2-B]哒嗪
参考文献:一种新型苯甲酰胺类化合物
标题:一种新型苯甲酰胺类化合物
摘要:本发明涉及药物化学领域,具体涉及一种新型苯甲酰胺类化合物或其药学上可接受的盐,其制备方法,以及含有这类化合物的药物组合物及其在制备抗肿瘤药物中的应用.

海关参考信息

专利信息


专利号:US-5196600-A
优先权日:1992-03-25
标题 :Synthesis of fluorinated dimethyl ethers
发明人:O'NEILL GERALD J
权利人:GRACE W R & CO
摘要:A novel process is disclosed for the synthesis of fluorinated dimethyl ethers of the formula CF 2 HOCCl x F y H 3- (x+y) wherein x is 0, 1 or 2; y is 1, 2 or 3; and wherein the total x+y is 1, 2 or 3. The process involves chlorination of methyl difluoromethyl ether to form a chlorinated reaction product, including at least one compound of the formula CF 2 HOCH 3-z Cl z , wherein z is 1, 2 or 3, which compound is then fluorinated with HF and/or an antimony salt and with or without separation from the chlorinated reaction product, to give a fluorinated reaction product including the aforementioned fluorinated dimethyl ethers.

专利号:US-5185474-A
优先权日:1990-10-02
标 题:Synthesis of fluorinated dimethyl ethers
发明人:O'NEILL GERALD J
权利人:GRACE W R & CO
摘要:A novel process is disclosed for the synthesis of fluorinated dimethyl ethers of the formula CF 2 HOCCl X F Y H 3- (X+Y) wherein X and Y are each independently 0, 1, 2 or 3 and wherein the total X+Y is 2 or 3. The process involves chlorination of methyl difluoromethyl ether to form a chlorinated reaction product, including at least one compound of the formula CF 2 HOCH 3-z Cl z , wherein z is 1, 2 or 3, which compound is then fluorinated, with or without separation from the chlorinated reaction product, to give a fluorinated reaction product including the aforementioned fluorinated dimethyl ethers.

专利号:US-4756739-A
优先权日:1985-12-21
标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents
发明人:FUSS ANDREAS; KOCH VOLKER
权利人:HOECHST AG
摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.

专利号:US-5711925-A
优先权日:1995-03-27
标题:Synthesis of pure disilicon hexafluoride
发明人:NODA TETSUIJI; SUZUKI HIROSHI; ARAKI HIROSHI
权利人:NAT RES INST METALS
摘要:Highly pure disilicon hexafluoride is synthesized by a process in which a suspension of a fluorination agent is made by dispersing this fluorination agent in an oxybenzene compound as a solvent and disilicon hexachloride is dripped in the suspension to be caused to react with the fluorination agent in nitrogen gas flows under atmospheric pressure, the oxybenzene being expressed by a following formula: ##STR1## (where each of R 1 and R 2 is an alkyl group alternatively having one or more substituents; carbon numbers summed up by R 1 and R 2 are equal to at least 2; and m≧1 and n≧0).

专利号:US-8377406-B1
优先权日:2012-08-29
标 题 :Synthesis of bis(fluorosulfonyl)imide
发明人:SINGH RAJENDRA P; MARTIN JERRY LYNN; POSHUSTA JOSEPH CARL
权利人:BOULDER IONICS CORP; SINGH RAJENDRA P; MARTIN JERRY LYNN; POSHUSTA JOSEPH CARL
摘要:The present invention provides methods for producing bis(fluorosulfonyl) compounds of the formula:n nF—S(O) 2 —Z—S(O) 2 —F  In nby contacting a nonfluorohalide compound of the formula:n nX—S(O) 2 —Z—S(O) 2 —Xn nwith bismuth trifluoride under conditions sufficient to produce the bis(fluorosulfonyl) compound of Formula I, where Z and X are those defined herein.

专利号:US-3641082-A
优先权日:1969-02-17
标题 :Process for the alkylation alkenylation or arylation of heavy-metla salts by means of organo-triptychsiloxazolidines
发明人:MULLER RICHARD; FREY HANS; DATHE CHRISTIAN
权利人:INST SILIKON & FLUORKARBONCHEM
摘要:PROCESS FOR THE ALKYLATOR, XXXVLATION OR ARYLATION OF SALTS OR HYDROXIDES OF HEAVY METALS, SUCH AS MERCURY, BXXOUTH, ANTIMONY AND XXX COMPRISING REACTING THEM WITH ORGANO-TRIPTYCH-SILEXXOLIDINES IN THE PRESENCE OF FLUORINE. THE PRODUCTS ACCORDING TO THIS INVENTION ARE USEFUL AS PHARMACEUTICALS AND PESTICIDES, AND MAY ALSO SERVE IN THE SYNTHESIS OF OTHER USEFUL PRODUCTS.
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参考DOI号:10.1016/j.bmcl.2004.02.008
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