CAS: 1009-22-9; N-(2-Bromo-4-Fluorophenyl)Acetamide

相似化合物

64695-81-4 1009-06-9 614-76-6

上下游产品

CAS号1003-98-1 2-溴-4-氟苯胺 | CAS号75-36-5 乙酰氯

N-(2-Bromophenyl)-N-Hydroxyacetamide置于potassium Fluoride,硫酰氟体系中,用 二氯甲烷 用作溶剂,化学反应 12.0H,以2.23 G的收率获得2'-溴-4'-氟乙酰苯胺
参考文献:一种4-氟取代芳基胺类化合物及其合成方法
标题:一种4-氟取代芳基胺类化合物及其合成方法
摘要:本发明公开了一种4‑氟取代芳基胺类化合物的合成方法,包括以下步骤:1)以酰基保护的苯基羟胺为底物,在极性溶剂中,以磺酰氟为氟源,在碱性条件下生成4‑氟取代苯胺类化合物;2)在稀酸性条件下或者pd催化氢化进行脱保护基团,得到所述4‑氟取代芳基胺类化合物.本发明合成的4‑氟取代的苯胺类化合物,由于氟原子引入极大程度上增加其亲脂性,因此能广泛用于含氟药物,农药以及染料中间体的制备;同时,本发明采用的原料均为工业化产品,价廉易得,具有市售;通过本发明制得的4‑氟芳基苯胺收率高,能够以大于90%的收率获得纯度>=99%的产物;本发明操作简单,成本低廉的工艺十分适用于工业化,能够广泛推广使用.

专利信息

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:CN-101885698-B
优先权日:2009-05-15
标题 :Pyrrolyl acrylamide compound and application thereof to synthesis of sunitinib

专利号:CN-101885698-A
优先权日:2009-05-15
标 题 :Pyrrolyl acrylamide compound and application thereof to synthesis of sunitinib

专利号:US-2020047165-A1
优先权日:2017-03-31
标 题:Method for the production of a material of plant origin that is rich in phenolic acids, comprising at least one metal, for carrying out organic synthesis reactions

专利号:US-11254597-B2
优先权日:2017-03-31
标题:Method for the production of a material of plant origin that is rich in phenolic acids, comprising at least one metal, for carrying out organic synthesis reactions

专利号:CN-111217718-A
优先权日:2020-03-11
标题:Synthesis method of sulfur-free 2-bromo-4-fluoroacetanilide