3-(苯硫基)丙腈置于硫酸,双氧水,溶剂黄146体系中,化学反应生成3-(苯磺酰)丙酸 参考文献:Reactions Of Mercaptans With Acrylic And Methacrylic Derivatives 标题:Reactions Of Mercaptans With Acrylic And Methacrylic Derivatives 摘要: Doi:10.1021/ja01202A024
专利号:US-12172982-B2 优先权日:2020-08-12 标 题:Synthesis of quinazoline compounds 发明人:LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH 权利人:GENENTECH INC; HOFFMANN LA ROCHE 摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.
专利号:US-12071422-B2 优先权日:2022-02-07 标 题 :Process for synthesis of quinazoline compounds 发明人:LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN 权利人:GENENTECH INC; HOFFMANN LA ROCHE 摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
专利号:WO-2022035790-A1 优先权日:2020-08-12 标题:Synthesis of quinazoline compounds
专利号:EP-4196470-A1 优先权日:2020-08-12 标 题:Synthesis of quinazoline compounds
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:EA-002100-B1 优先权日:1996-12-23 标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK