CAS: 10269-01-9; (3-Bromophenyl)Methanamine

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间溴苯甲腈置于zr12(μ3-O)5[(μ3-O)Cocl]8[(μ2-O)2(μ3-O)Cocl]3Li3(Triphenyldicarboxylate)9,氢气体系中,用 甲苯 用作溶剂,110.0 °C,4.0 Mpa 条件下,反应 42.0H,以100%的收率获得3-溴苄胺
参考文献:新型 Zr12(μ3-O)8(μ3-Oh)8(μ2-Oh)6 金属-有机骨架节点的单中心钴催化剂,用于硝基芳烃,腈类和异氰化物的高活性加氢
标题:新型 Zr12(μ3-O)8(μ3-Oh)8(μ2-Oh)6 金属-有机骨架节点的单中心钴催化剂,用于硝基芳烃,腈类和异氰化物的高活性加氢
摘要:我们在此报告了由三苯基二羧酸 (H2Tpdc) 和前所未有的 Zr12 二级构建单元 (Sbu) 构成的坚固多孔金属有机骨架 (Mof) Zr12-Tpdc 的合成:Zr12(μ3-O)8(μ3-Oh)8(μ2-Oh)6.Zr12-Sbu 可以看作是通过六个 μ2-Oh 基团从两个常见的 Zr6 簇中二聚化的无机节点.Zr12-Tpdc Sbu 用 Cocl2 金属化,然后用 Nabet3H 处理,提供了一种高活性且可重复使用的固体 Zr12-Tpdc-Co 催化剂,用于将硝基芳烃,腈和异氰化物氢化成相应的胺,具有优异的活性和选择性.这项工作强调了通过调整 Sbu 的电子和空间特性来设计新型 Mof 负载的单中心固体催化剂的机会.
Doi:10.1021/jacs.7B02394

专利信息

专利号:US-8357819-B2
优先权日:2007-05-11
标 题 :Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid
发明人：BOITEAU JEAN-GUY
权利人:GALDERMA RES & DEV; BOITEAU JEAN-GUY
摘要:The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): n nand also to the process for the synthesis of the reaction intermediates of general formula (XII), and to the said compounds when R2 is chosen from the methyl, trifluoromethyl, phenyl and 4-tolyl radicals:

专利号:US-9102698-B2
优先权日:2007-03-14
标 题:Process for the synthesis of IB-MECA
发明人：BRUZINSKI PAUL; LIU XUEJUN; GIBB CAMERON; HERNANDEZ-ABAD PEDRO E
权利人:BRUZINSKI PAUL; LIU XUEJUN; GIBB CAMERON; HERNANDEZ-ABAD PEDRO E; CAN FITE BIOPHARMA LTD
摘要:The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-2001024798-A1
优先权日:1998-06-11
标题:Biomimetic combinatorial synthesis
发明人：SHAIR MATTHEW D; LINDSLEY CRAIG W; PELISH HENRY E; SHEEHAN SCOTT M; GOESS BRIAN C; LAYTON MARK E; CHAN LAWRENCE K; CHEN CHUO; WESTWOOD NICHOLAS J
摘要:The present invention provides biomimetic compounds and libraries thereof, as well as methods for their production. In general, the inventive method involves the selection of a desired biological synthetic pathway and mimics that synthetic pathway utilizing modern synthetic tools. The structures formed from this method are preferably generated in fewer than four steps. These scaffold structures can then be functionalized to yield biomimetic compounds and libraries of compounds. In preferred embodiments, biomimetic compounds and libraries are generated from an oxidative phenolic coupling reaction. In other particularly preferred embodiments, the compounds and libraries of compounds are generated from cascade reactions to yield bicyclo [n. 3.1 ] ring systems, medium ring systems, and fused ring systems. In addition to compounds, libraries and methods for their production, the present invention also provides pharmaceutical compositions and methods and kits for determining one or more biological activities of the library members.

专利号:US-2010087636-A1
优先权日:2007-03-14
标题:Process for the synthesis of ib-meca