CAS: 117048-59-6; (Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol

相似化合物

586410-08-4 537-42-8 116519-00-7

上下游产品

CAS号847063-26-7 3-tert-butyldim... | CAS号621-59-0 异香兰素； 3-羟基-4-甲氧... | CAS号108683-61-0 Triphenyl-[(3,4... | CAS号39500-10-2 (E)-3-(3-acetox... | CAS号86-81-7 3,4,5-三甲氧基苯甲醛 | CAS号111394-52-6 3-hydroxy-4-met... | CAS号61240-20-8 三苯基(3,4,5-三甲氧苄基)溴化磷

(E)-3-(3-Acetoxy-4-Methoxyphenyl)-2-(3,4,5-Trimethoxyphenyl)Acrylic Acid置于喹啉,Copper Chromite 吡啶,乙酸酐,盐酸,Sodium Hydroxide,水体系中,化学反应 2.25H,以59%的收率获得(Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯
参考文献:Wo2007/59118
标题:Wo2007/59118

专利信息

专利号:US-2025101045-A1
优先权日:2022-01-18
标题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives
发明人：DAS BHASKAR
权利人:LONG ISLAND UNIV
摘要:The present disclosure is concerned with borylated amidoximes useful in the synthesis of biologically relevant drug-like molecules, including functionalized oxadizole and quinazolinone derivatives. Also disclosed are methods of making borylated amidoximes, methods of making functionalized oxadiazole and quinazolinone compounds using the amidoximes, and functionalized oxadiazole and quinazolinone compounds prepared from borylated amidoximes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-7105695-B2
优先权日:2001-12-21
标题 :Synthesis of combretastatin A-2 prodrugs
发明人：PETTIT GEORGE R; MOSER BRYAN R
权利人:UNIV ARIZONA STATE
摘要:The original synthesis of combretastatin A-2 (1a) was modified to provide an efficient scale-up procedure for obtaining this antineoplastic stilbene. Subsequent conversion to a useful prodrug was accomplished by phosphorylation employing in situ formation of dibenzylchlorophosphite followed by cleavage of the benzyl ester protective groups with bromotrimethylsilane to afford phosphoric acid intermediate 11. The latter was immediately treated with sodium methoxide to complete a practical route to the disodium phosphate prodrug (2a). The phosphoric acid precursor (11) of phosphate 2a was employed in a parallel series of reactions to produce a selection of metal and ammonium cation prodrug candidates. Each of the phosphate salts (2a–q) was evaluated with respect to relative solubility behavior, cancer cell growth inhibition, and antimicrobial activity.

专利号:US-2005130221-A1
优先权日:2001-02-01
标 题:Synthesis for the preparation of compounds for screening as potential tubulin binding agents
发明人：FLYNN BERNARD L; HAMEL ERNEST
权利人:US GOV HEALTH & HUMAN SERV
摘要:The present invention relates to methods for the synthesis of chemical compounds for screening as potential tubulin polymerization inhibitors. The invention also provides chemical compounds with tubulin polymerization inhibitor activity.

专利号:US-2009099218-A1
优先权日:2007-09-17
标题 :Synthesis of novel tubulin polymerization inhibitors: benzoylphenylurea (bpu) sulfur analogs
发明人：KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
权利人:KHAN SAEED R; HALLUR GURULINGAPPA; HIDALGO MANUEL; JIMENO ANTONIO
摘要:This invention provides a series of BPU analogues; their synthesis and evaluated biological activity. BPU sulfur analogues were found to possess up to 20 fold increased potency, when compared to compound 1, in various cancerous cell lines.