CAS: 456-41-7; 1-(Bromomethyl)-3-Fluorobenzene

上下游产品

CAS号352-70-5 3-氟甲苯 | CAS号456-42-8 间氟氯苄 | CAS号28490-56-4 5-氟-2-碘甲苯 | CAS号456-47-3 3-氟苄醇 | CAS号108-44-1 3-甲基苯胺 | CAS号506-68-3 溴化氰 | CAS号351-25-7 benzyl-(3-fluor... | CAS号352-70-5 3-氟甲苯 | CAS号351-22-4 3,3'-difluoro-b... | CAS号456-42-8 间氟氯苄 | CAS号404-70-6 3-氟苯乙胺 | CAS号456-48-4 3-氟苯甲醛 | CAS号455-34-5 3-氟苯亚甲基二溴 | CAS号443882-99-3 3-氯-4-(3-氟苄氧基)硝基苯 | CAS号458-04-8 间氟苯乙酰氯间氟苯乙酰氯 | CAS号501-00-8 3-氟苯乙腈 | CAS号2248-12-6 1-but-3-enyl-3-...

3-氟苄醇置于三溴化磷体系中,用 二氯甲烷 作为反应溶剂,化学反应 0.5H,反应生成 3-氟溴苄
参考文献:通过钯催化的c 由邻烯基苯酚一步合成苯并呋喃.h功能化
标题:通过钯催化的c 由邻烯基苯酚一步合成苯并呋喃.h功能化
摘要:C(的脱氢氧合sp 2)与分子内酚羟基h键已被开发,这提供了从结构上多样的苯并呋喃一个简单和简明的访问邻-Alkenylphenols.该反应由钯/碳(pd / C)催化,不带任何氧化剂且不牺牲氢受体.
DOI:10.1002/adsc.201600082

专利信息

专利号:WO-9943409-A1
优先权日:1998-02-27
标 题:Hplc fractionation of complex chemical mixtures
发明人：COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
权利人:ISIS PHARMACEUTICALS INC; COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
摘要:The rapid deconvolution of complex chemical mixtures, such as combinatorial libraries prepared via solution-phase simultaneous addition of functionalities is demonstrated using HPLC. Libraries containing 25-216 members were screened for biological activity and active libraries are fractionated into discreet pools using preferred reversed-phase HPLC. The entire process can be completed from a single synthesis of 15-50 mg, without the need for fixed positions, serial synthesis, or tagging.

专利号:WO-2013080218-A1
优先权日:2011-11-28
标 题 :Novel intermediates and process for the preparation of lapatinib and its pharmaceutically acceptable salts
发明人：LAHIRI SASWATA; GUPTA NITIN; SINGH HEMANT KUMAR; HANDA VISHAL; SANGHANI SUNIL
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention discloses novel intermediates and processes for the synthesis of Lapatinib and its pharmaceutically acceptable salts thereof.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6150129-A
优先权日:1996-08-01
标 题 :Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions
发明人：COOK PHILLIP DAN; KAWASAKI ANDREW M; KUNG PEI PEI
权利人:ISIS PHARMACEUTICALS INC
摘要:Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The compounds and compositions of the invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents including employment as species for effecting combinatorial synthesis.