CAS: 64221-86-9; (5R,6S)-3-((2-Formimidamidoethyl)Thio)-6-((R)-1-Hydroxyethyl)-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid

上下游产品

N-(N'-p-nitrobenzyloxycarbonyl) formimidoyl cysteamine (5R,6S)-3-(Diphenoxy-phosphoryloxy)-6-((R)-1-hydroxy-ethyl)-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 22H30N4O6SSiC22H30N4O6SSi p-nitrobenzyl 6-(1'-hydroxyethyl)-1-azabicyclo(3.2.0)heptane-3,7-dione-2-carboxylate

专利信息

专利号:US-5145957-A
优先权日:1988-03-18
标 题:Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:EP-0269236-B1
优先权日:1986-10-24
标题:Process for synthesis of a chiral azetidinone
摘要:A process is described for the stereo-controlled synthesis of 3-(R)-3-[1'-(R)-hydroxyethyl]-4-(R)-benzoyl-2-oxo-1-aze tidines and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:EP-0343716-A1
优先权日:1988-05-23
标 题 :Process for synthesis of a beta-lactam carbapenem intermediate
发明人：LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonyl­methyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.

专利号:US-5037974-A
优先权日:1988-05-23
标题:Cyclization process for synthesis of a beta-lactam carbapenem intermediate
发明人：LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonylmethyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.

专利号:EP-0333268-A1
优先权日:1988-03-18
标题:Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereo-­controlled synthesis of (3R,4R)-3-[(1R)-1-hydroxy­ethyl]-4-benzoyloxyazetidin-2-ones and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.