专利号:WO-2023039068-A1 优先权日:2021-09-08 标题:Compositions and methods for synthesis of peptide nucleic acid intermediates 发明人:COULL JAMES M; GILDEA BRIAN D 权利人:NEUBASE THERAPEUTICS INC 摘要:The present disclosure provides intermediates for the synthesis of peptide nucleic acid (PNA) backbones and monomers, such as cyclic intermediates, and methods of making the same.
专利号:US-6121430-A 优先权日:1998-12-28 标 题 :Regiospecific synthesis of glucose-based surfactants 发明人:LINHARDT ROBERT J; BAZIN HELENE G 权利人:UNIV IOWA RES FOUND 摘要:New glucose-based surfactants and methods of their synthesis are described. The surfactants are synthesized through the preparation of an intermediate glucose 4,6-cyclic sulfate. The surfactants are economical to prepare and have excellent surface-active properties.
专利号:US-6277982-B1 优先权日:1999-08-20 标题:Alkylation of alcohols, amines, thiols and their derivatives by cyclic sulfate intermediates 发明人:FRASER ALLISTER S; MANOHARAN MUTHIAH; COOK PHILLIP DAN; JUNG MICHAEL E; KAWASAKI ANDREW M 权利人:ISIS PHARMACEUTICALS INC 摘要:Methods for the alkylation of alcohols, amines and thiols by the use of cyclic sulfates are disclosed. The alkylated sulfates formed are versatile intermediates which may be further elaborated by methods of the invention. In particular, methods for the alkylation of the 2′, 3′ or 5′-hydroxy position of nucleosides and nucleoside analogs with cyclic sulfates to form the 2′, 3′ or 5′-O-alkyl sulfate modified compounds are disclosed. Displacement of the 2′,3′ or 5′-O-sulfate with a nucleophile provides 2′, 3′ or 5′-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.
专利号:US-8669382-B2 优先权日:2010-06-03 标题 :Method for producing (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor 发明人:ISHII AKIHIRO; NAGURA HIROKATSU; TSURUTA HIDEYUKI 权利人:ISHII AKIHIRO; NAGURA HIROKATSU; TSURUTA HIDEYUKI; CENTRAL GLASS CO LTD 摘要:In the presence invention, a (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is produced in the form of a ring-opened fluorinated compound by reaction of a 1,2-diol with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base and, optionally, a fluoride ion source. The production method of the present invention secures less number of process steps as compared to the conventional production method (shortening of three steps: cyclic sulfurous esterification, oxidation and ring-opening fluorination to one step) and satisfies the requirements for industrial production (high yield and high reproductivity). The thus-obtained (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is useful as an important intermediate for the synthesis of 2′-deoxy-2′-fluoro-2′-C-methylcytidine with antivirus activity.
专利号:US-6184196-B1 优先权日:1998-05-27 标 题 :Sucrose based surfactants and methods thereof 发明人:BAZIN HELENE G; POLAT TULAY; LINHARDT ROBERT J 权利人:UNIV IOWA RES FOUND 摘要:The invention relates to the synthesis of sulfonated sucrose compounds, surfactants and intermediate cyclic sulfates.
专利号:WO-0039137-A2 优先权日:1998-12-28 标 题:Regiospecific synthesis of glucose-based surfactants