CAS: 830346-47-9; 1-(2-Fluoro-6-(Trifluoromethyl)Benzyl)-6-Methylpyrimidine-2,4(1H,3H)-Dione

相似化合物

1150560-54-5 830346-48-0 2995282-43-2

上下游产品

CAS号674-82-8 双乙烯酮 | CAS号830346-46-8 1-[2-氟-6-(三氟甲基)苄基]脲 | CAS号1694-31-1 乙酰乙酸叔丁酯 | CAS号75-77-4 三甲基氯硅烷 | CAS号463-51-4 乙烯酮 | CAS号1150560-54-5 1-[2-氟-6-(三氟甲基)...

2-氟-6-(三氟甲基)苯甲醛置于盐酸,盐酸羟胺,氢气,碳酸氢钠,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,乙醇,水,N,N-二甲基甲酰胺,异丙醇 作为反应溶剂,15.0~130.0 °C,300.01 Kpa 条件下,反应 14.0H,反应生成 1-[2-氟-6-(三氟甲基)苄基]-6-甲基嘧啶-2,4(1H,3H)-二酮
参考文献: Processes To Produce Elagolix[fr] Processus De Production D'élagolix
标题: Processes To Produce Elagolix[fr] Processus De Production D'élagolix
摘要:本发明涉及一种用于制备依诺司特及其盐和中间化合物的可扩展工艺.

专利信息

专利号:US-11858901-B2
优先权日:2019-10-30
标 题:3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix
发明人：BALLETTE ROBERTO; JIMÉNEZ ALONSO OSCAR; GARCÃ?A GARCÃ?A ELENA; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.

专利号:US-11840519-B2
优先权日:2019-09-03
标 题 :Process for the synthesis of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)-phenyl]methyl]-3,6-dihydro-4-methyl-2.6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]-butanoic acid (elagolix sodium salt) and intermediates of said process
发明人：LENNA ROBERTO; FASANA ANDREA; ORTIZ JERRY
权利人:IND CHIMICA SRL
摘要:The present invention to a process for the preparation of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-amino]-butanoic acid, compound also known as Elagolix sodium salt, having the formula (I) reported below:

专利号:US-2022411382-A1
优先权日:2019-10-30
标 题 :3-((r)-2-(amino-2-phenylethyl)-1-(2-fluoro-6 trifluoromethyl benzyl)-5-iodo-6-methyl-1h-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix

专利号:ES-2822398-A1
优先权日:2019-10-30
标 题 :3 - ((R) -2- (Amino-2-phenylethyl) -1- (2-fluoro-6-trifluoromethylbenzyl) -5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt of the same, procedure for its preparation and its use in the synthesis of elagolix

专利号:ES-2822398-B2
优先权日:2019-10-30
标 题:3-((R)-2-(Amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidin-2,4-dione or a salt of the same, procedure for its preparation and its use in the synthesis of elagolix

专利号:WO-2021083554-A1
优先权日:2019-10-30
标题:3-((r)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethyl benzyl)-5-iodo-6-methyl-1h-pyrimidine-2,4-dione or a salt thereof, process for its preparation, and its use in the synthesis of elagolix