1-Methoxybicyclo-<3.1.0>-Hexan置于4,4'-联苯甲腈体系中,用 甲醇 作为反应溶剂,化学反应生成 环己酮二甲缩酮 参考文献:Ring Expansions Via Photoinduced Single Electron Transfer Promoted Opening Of Cyclopropyl Ethers 标题:Ring Expansions Via Photoinduced Single Electron Transfer Promoted Opening Of Cyclopropyl Ethers 摘要: DOI:10.1021/jo00258A044
专利号:US-7358382-B2 优先权日:2001-08-03 标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.
专利号:US-7368568-B2 优先权日:2001-08-03 标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
专利号:US-6933385-B2 优先权日:2001-08-03 标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:SCHERING AG 摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
专利号:US-10717718-B2 优先权日:2015-11-17 标 题:5-azido-5-deoxy-2 :3-isopropylidene-D-arabinose compounds; their method of manufacture and their use for the synthesis of ARA-N3, KDO-N3 and 4EKDO-N3 发明人:VAUZEILLES BORIS; MAS PONS JORDI; BARON AURÈLIE 权利人:CENTRE NAT RECH SCIENT 摘要:Disclosed are new compounds of formulae: n nWherein: R 1 and R 2 can be independently H; a C 1 to C 6 alkyl including methyl, ethyl, propyl, butyl; aryl including phenyl, para-methoxyphenyl; or R 1 ,R 2 together with the carbon C-6 can be a cyclopentylidene or cyclohexylidene; each of these groups being substituted or not; and R 3 can be a C 1 to C 6 alkyl including methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl; or aryl including phenyl, methylphenyl, ethylphenyl, each of these groups being substituted or not. The invention also relates to their method of manufacture and their use for the synthesis of Ara-N 3 , Kdo-N 3 and 4eKdo-N 3 .
专利号:WO-0172706-A1 优先权日:2000-03-28 标题 :Synthesis of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid hemi calcium salt (atorvastatin) 发明人:SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH 权利人:BIOCON LTD; SAMBASIVAN GANESH; SRIDHARAN MADHAVAN; PADUDEVASTANA SATHYASHANKER; POORNAPRAJNA ACHARYA; MATHEW JOY; SRINATH SUMITHRA; NAIR SATHEESH 摘要:The present invention discusses a novel process for the synthesis of [R-(R*,R*)]-2-(4-fluorophenyl)-B,D-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt by using 4-fluoro-α-[2-methyl-1-oxopropyl]η-oxo-N-β-diphenylbenzene butaneamide with (4R)-methyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-3-acetate. The compound so prepared is useful as inhibitors of the enzyme HMG-CoA reductase and are thus used as hypolipidemic and hypocholesterolemic agents.
专利号:US-6518438-B2 优先权日:1996-08-23 标题:Preparation of cyclohexene carboxylate derivatives 发明人:KENT KENNETH M; KIM CHOUNG U; MCGEE LAWRENCE R; MUNGER JOHN D; PRISBE ERNEST J; POSTICH MICHAEL J; ROHLOFF JOHN C; KELLY DAPHNE E; WILLIAMS MATTHEW A; ZHANG LIJUN 权利人:GILEAD SCIENCES INC 摘要:The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
[参考文献]: M Ogata, Et Al. Synthesis And Oral Antifungal Activity Of Novel Azolylpropanolones And Related Compounds. J Med Chem. 1987 Jun;30(6):1054-68.
合成参考文献
摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 420. 摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 389. 摘要:Vil’, V. A.; Bityukov, O. V.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2019) 3, 408. 参考文献:10.1038/ncomms14190 摘要:Meng Q, Hou M, Liu H, Song J, Han B. Synthesis of ketones from biomass-derived feedstock. Nature Communications. 2017 Jan 31;8(1):14190. doi: 10.1038/ncomms14190.