CAS: 115029-23-7; 2-Fluoro-5-(Trifluoromethyl)Benzoic Acid

相似化合物

146137-78-2 207974-09-2 4088-84-0

上下游产品

CAS号402-44-8 4-氟三氟甲苯 | CAS号124-38-9 二氧化碳 | CAS号207981-46-2 2-氟-5-(三氟甲基)苯甲酰氯 | CAS号865471-20-1 2-吗啉-5-(三氟甲基)苯甲酸

4-氟三氟甲苯置于sodium Hydroxide,正丁基锂体系中,用 四氢呋喃,正己烷,水,乙酸乙酯 用作溶剂,以64%的收率获得2-氟-5-三氟甲基苯甲酸
参考文献:Fused Aromatic Oxazepinones,Thiazepinones,Diazepinones And Sulfur
标题:Fused Aromatic Oxazepinones,Thiazepinones,Diazepinones And Sulfur
摘要:芳香族氮杂七元酮和硫醚的化学式为##str1##其中;A为苯,萘,喹啉或吡啶;B为氧或硫;E为氧,硫或##str2##n为1,2或3;Z为氨基或含氮杂环的基团;R为氢,较低烷基,环烷基或苯基较低烷基;Y为卤素,较低烷基,较低烷氧基,二较低烷基氨基,硝基,氨基,较低乙酰氨基,三氟甲基,苯基或被从卤素,较低烷基,较低烷氧基,二较低烷基氨基,硝基,氨基,较低酰胺基或三氟甲基中选择的一个至三个y'基团取代的苯基;具有抗组胺作用,公开了其制备方法和化学中间体.

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-10233182-B2
优先权日:2014-04-04
标题 :Substituted spirocyclic inhibitors of autotaxin
发明人：BABISS LEE; CLARK MATTHEW; KEEFE ANTHONY D; MULVIHILL MARK J; NI HAIHONG; RENZETTI LOUIS; RUEBSAM FRANK; WANG CE; XIE ZHIFENG; ZHANG YING
权利人:X RX INC
摘要:The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.

专利号:EP-4428132-A1
优先权日:2023-03-08
标题:Slack-activating compounds and their medical use
发明人：SCHMIDTKO ACHIM; PROSCHAK EUGEN; BALZULAT ANNIKA; ZHU WENXIN; FLAUAUS CATHRIN; STEINHILBER DIETER; LU RUIRUI; HERNANDEZ OLMOS VICTOR; HEERING JAN
权利人:JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN
摘要:The present invention pertains to novel compounds and their synthesis which are structurally derived from 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[ b , f ][1,4]oxazepine. The compounds of the invention were shown in a comparative study to bind and activate potassium channels, in particular Slack. Based on their activating activity, the compounds of the invention and pharmaceutical compositions containing them can be used in various therapeutic applications for the treatment or prevention of pathologies.