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专利信息
专利号:US-11078073-B2
优先权日:2015-02-23
标 题:Self-processing synthesis of hybrid nanostructures
发明人:YERUSHALMI ROIE; PALTIEL YOSSEF; PINCHAS-HAZUT ORI; WAICHMAN SHARON; ZIV AMIR; YOCHELIS SHIRA
权利人:YISSUM RES DEV CO OF HEBREW UNIV JERUSALEM LTD
摘要:Provided is a self-processing synthesis of hybrid nanostructures, novel nanostructures and uses thereof in the construction of electronic and optoelectronic devices.
专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人:WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人:HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.
专利号:US-10913056-B2
优先权日:2017-07-31
标 题:Method for synthesis of copper/copper oxide nanocrystals
发明人:CHEN GUGANG; HARUTYUNYAN AVETIK; RAO YI; LI XIA
权利人:HONDA MOTOR CO LTD; UNIV TEMPLE; TEMPLE UNIV OF THE COMMONWEALTH SYSTEM OF HI
摘要:A simple approach to produce mixed Cu/Cu 2 O nanocrystals having a specific morphology by controlling the reaction temperature during Cu/Cu 2 O nanocrystals synthesis. Other variables are kept constant, such as the amount of reactants, while the reaction temperatures is maintained at a predetermined temperature of 70° C., 30° C. or 0° C., which are used to produce different and controlled morphologies for the Cu/Cu 2 O nanocrystals. The reaction mixture includes a copper ion contributor, a capping agent, a pH adjustor, and reducing agent. The reaction mixture is held at the predetermined temperature for three hours to produce the Cu/Cu 2 O nanocrystals. The synthesis method has advantages such as mass production, easy operation, and high reproducibility.
专利号:US-4284582-A
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
发明人:KAYE ALBERT E; TUCKER ALAN C
权利人:ICI LTD
摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.
专利号:US-7951961-B2
优先权日:2006-07-07
标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof
发明人:SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT
权利人:PIRAMAL LIFE SCIENCES LTD
摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.