CAS: 158353-15-2; Pyraclonil

该化合物是一种选择性除草剂,属于丙烯醇衍生物化学类,主要用于稻田大叶草和草草的发芽前和早期出血后控制. 米拉克罗尼勒作为一种抗原素氧化酶(PPO)抑制剂,干扰叶绿素合成,导致目标杂草迅速脱贫.其主要优势包括低施用率高效,长期残留活动以及与综合杂草管理系统的兼容性. 复合物展示有利于环境的特征,包括对非目标生物的低毒性和减少沥滤风险. 米拉克隆尼勒对于抗除草剂的人群的功效特别宝贵.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

propargyl p-toluenesulfonate 5-Chlorovaleroyl chloride

合成工艺路线路线简述

    2-Hydrazino-3-Chloropyrazolo[1,5-A]-4,5,6,7-Tetrahydropyridine置于甲酸,Sodium Carbonate,溶剂黄146体系中,用 四氢呋喃,甲醇,乙醇 用作溶剂,化学反应 46.0H,反应生成双唑草腈
    参考文献:一种双唑草腈的合成方法
    标题:一种双唑草腈的合成方法
    摘要:本发明公开了一种双唑草腈的合成方法,属于除草剂技术领域,该合成方法以甲酸酯,丙二腈,5‑氯戊酰氯,三氯乙烯,水合肼,对甲苯磺酸丙炔醇酯为主要原料,经过七步反应,得到双唑草腈.本发明工艺路线短,只需七步反应就可以合成出双唑草腈,比现有的合成方法减少了三步,大幅度地提高了收率,降低了生产成本.

    海关参考信息

    专利信息


    专利号:WO-2024256370-A1
    优先权日:2023-06-13
    标 题 :Synthesis of glufosinate using an amidase-based process
    发明人:ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

    专利号:US-2025120400-A1
    优先权日:2021-12-10
    标题:Synthesis of glufosinate using a hydantoinase-based process
    发明人:DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
    权利人:BASF SE
    摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

    专利号:US-11919928-B2
    优先权日:2016-03-16
    标题 :Method for producing dihydrotentoxin
    发明人:KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
    权利人:KUMIAI CHEMICAL INDUSTRY CO
    摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

    专利号:US-2021386068-A1
    优先权日:2018-11-07
    标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
    发明人:KISTER JEREMY; SATCHIVI NORBERT M
    权利人:CORTEVA AGRISCIENCE LLC
    摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

    专利号:US-2021352899-A1
    优先权日:2018-11-07
    标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
    发明人:KISTER JEREMY; SATCHIVI NORBERT M
    权利人:CORTEVA AGRISCIENCE LLC
    摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.

    专利号:ES-2717283-T3
    优先权日:2012-07-24
    标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids
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    主要参考文献


    1: Li W, Hu J. Photodegradation of the novel herbicide pyraclonil in aqueous solution: Kinetics, identification of photoproducts, mechanism, and toxicity assessment. Environ Pollut. 2024 Sep 15;357:124381. doi: 10.1016/j.envpol.2024.124381. Epub 2024 Jun 19. 31(14):21857-21868. doi: 10.1007/s11356-024-32597-3. Epub 2024 Feb 24.
    197:105648. doi: 10.1016/j.pestbp.2023.105648. Epub 2023 Oct 14.
    182:105038. doi: 10.1016/j.pestbp.2022.105038. Epub 2022 Jan 21. 46(3):267-273. doi: 10.1584/jpestics.D21-018.

    合成参考文献


    参考文献:10.1007/s11696-024-03534-y
    摘要:Sharma S, Sharma P, Singh V, Vaishali, Vashistha VK, Das DK, Pal K, Kumar N, Devi P. Exploitation of pyrazole C-3/5 carbaldehydes towards the development of therapeutically valuable scaffolds: a review. Chem. Pap. 2024 May 31;78(11):6287–314. doi: 10.1007/s11696-024-03534-y.
    参考文献:10.1007/s13157-024-01823-6
    摘要:Watanabe R, Kubo S, Fukuoka T, Takahashi S, Kobayashi K, Ohba S. Do Fallow Field Biotopes Function as Habitats for Aquatic Insects Similar to Rice Paddy Fields and Irrigation Ponds Wetlands. 2024 Jun;44(5). doi: 10.1007/s13157-024-01823-6.
    参考文献:10.1007/s10750-025-05949-4
    摘要:Watanabe R, Kubo S, Fukuoka T, Takahashi S, Kobayashi K, Sagawa S, Ohba S. Effects of early summer plowing on aquatic insects in fallow field biotopes. Hydrobiologia. 2025 Aug 14;853(1):315–36. doi: 10.1007/s10750-025-05949-4.
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