2-甲氧基-吡啶 1-氧化物置于三甲基氯硅烷,Sodium Iodide,锌体系中,用 乙腈 用作溶剂,化学反应 1.0H,以81%的收率获得2-甲氧基吡啶 参考文献:A New Method For Deoxygenation Of Heteroaromaticn-Oxides With Chlorotrimethylsi Lane/sodium Iodide/zinc 标题:A New Method For Deoxygenation Of Heteroaromaticn-Oxides With Chlorotrimethylsi Lane/sodium Iodide/zinc 摘要:杂芳香n-氧化物在乙腈中容易通过氯三甲基硅烷/碘化钠/锌体系去氧,以非常好产率得到相应的母体碱. Doi:10.1246/cl.1981.921
专利号:US-2008086013-A1 优先权日:2006-06-15 标 题:Carbometallation of alkynes and improved synthesis of uniquinones 发明人:LIPSHUTZ BRUCE H 权利人:UNIV CALIFORNIA 摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-10011567-B1 优先权日:2017-03-09 标题 :Method for the synthesis of acrylate derivatives 发明人:WANG MINGWEN; ZHANG YUE 权利人:INNOSCI LLC 摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.
专利号:US-2007260076-A1 优先权日:2003-12-05 标 题:Practical, Cost-Effective Synthesis of Ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 权利人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-2006167289-A1 优先权日:2003-12-05 标题 :Practical, cost-effective synthesis of ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SCHEIN KARIN; WETTERICH FRANK 权利人:ZYMES LLC 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:WO-2025122636-A1 优先权日:2023-12-04 标题:Method for the synthesis of acrylate derivatives 发明人:CAICEDO-CARVAJAL CARLOS; KATZ JORDAN; CHOI SEAN 权利人:ORTHOBOND CORP 摘要:The disclosure relates to the synthesis of quaternary salts of various acrylates in high yield and high purity.
专利号:US-2015336866-A1 优先权日:2013-01-01 标题:Synthesis of difluoromethyl ethers and sulfides 发明人:HARTWIG JOHN; FIER PATRICK 权利人:UNIV CALIFORNIA 摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.
[参考文献]: Masazumi Tamura, Et Al. Self-Assembled Hybrid Metal Oxide Base Catalysts Prepared By Simply Mixing With Organic Modifiers. Nat Commun. 2015 Oct 5:6:8580.
合成参考文献
摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 149. 摘要:Hutskalova, V.; Sparr, C., Science of Synthesis Knowledge Updates, (2022) 1, 42. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 179. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 165. 摘要:Inamoto, K., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 400.