CAS: 20154-03-4; 3-(Trifluoromethyl)-1H-Pyrazole

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CAS号59938-06-6 (E)-4-乙氧基-1,1,1... | CAS号910136-24-2 (Z)-4-乙氧基-1,1,1... | CAS号2644-70-4 盐酸肼 | CAS号5535-48-8 苯基乙烯基砜 | CAS号145574-05-6 TRIFLUOROACETYL... | CAS号288-13-1 吡唑 | CAS号2314-97-8 三氟碘甲烷 | CAS号354-58-5 1,1,1-三氯-2,2,2-三氟乙烷 | CAS号109-92-2 乙烯基乙醚 | CAS号99498-65-4 1-苯基-3-三氟甲基吡唑 | CAS号866638-72-4 4-碘-3-(三氟甲基)-1H-吡唑 | CAS号128694-66-6 2-乙基-5-三氟甲基-2H-... | CAS号1621-91-6 吡唑-3-羧酸 | CAS号154471-65-5 1-甲基-3-三氟甲基-1H-吡唑 | CAS号19968-17-3 4-溴-3-三氟甲基吡唑 | CAS号401517-15-5 4-Chloro-5-(tri...

1-乙氧基-3-三氟甲基-1,3-丁二烯置于盐酸肼,三乙胺体系中,用 乙醇 用作溶剂,化学反应生成3-(三氟甲基)吡唑
参考文献: Substituted Pyrazolyl-Based Carboxamide And Urea Derivatives Bearing A Phenyl Moiety Substituted With An So2-Containing Group As Vanilloid Receptor Ligands[fr] Dérivés De Carboxamide Et D'Urée à Base De Pyrazolyle Substitué Portant Un Fragment Phényle Remplacé Par Un Groupe Contenant So2 Comme Ligands Des Récepteurs Vanilloïdes
标题: Substituted Pyrazolyl-Based Carboxamide And Urea Derivatives Bearing A Phenyl Moiety Substituted With An So2-Containing Group As Vanilloid Receptor Ligands[fr] Dérivés De Carboxamide Et D'Urée à Base De Pyrazolyle Substitué Portant Un Fragment Phényle Remplacé Par Un Groupe Contenant So2 Comme Ligands Des Récepteurs Vanilloïdes
摘要:这项发明涉及取代吡唑基的羧酰胺和脲衍生物,其苯基部分取代有含有s02基团的香草醛受体配体,以及含有这些化合物的药物组合物,以及这些化合物用于治疗和/或预防疼痛以及其他疾病和/或紊乱.

专利信息

专利号:US-11848117-B2
优先权日:2017-12-06
标题:Thin and uniform silver nanowires, method of synthesis and transparent conductive films formed from the nanowires
发明人：HU YONGXING; LI YING-SYI; YANG XIQIANG; ANG JING SHUN; VIRKAR AJAY
权利人:C3 NANO INC
摘要:Highly uniform and thin silver nanowires are described having average diameters below 20 nm and a small standard deviation of the diameters. The silver nanowires have a high aspect ratio. The silver nanowires can be characterized by a small number of nanowires having a diameter greater than 18 nm as well as with a blue shifted narrow absorption spectrum in a dilute solution. Methods are described to allow for the synthesis of the narrow uniform silver nanowires. Transparent conductive films formed from the thin, uniform silver nanowires can have very low levels of haze and low values of ΔL*, the diffusive luminosity, such that the transparent conductive films can provide little alteration of the appearance of a black background.

专利号:US-8981115-B2
优先权日:2008-09-30
标 题 :Process for the synthesis of halogenated cyclic compounds
发明人：BRAUN MAX
权利人:SOLVAY
摘要:A process for the manufacture of a cyclic compound of formula (I) n n n n n n n n n n which comprises (a) adding an acid halide of formula R 1 —C (O)—X, to a vinyl ether of formula (II): CH 2 â•?CH—OR 2 , to produce an addition product, and (b) reacting the addition product with a compound of formula (III): Y-A-Z; wherein R 1 is a halogenated alkyl group; wherein X is fluorine, chlorine, or bromine; wherein R 2 is an alkyl group, an aralkyl group, or an aryl group; wherein Z and Y designate independently carbon or a heteroatom; and wherein A is a linking group between Z and Y comprising 0, 1, 2 or 3 atoms in the cycle.

专利号:US-6465656-B2
优先权日:1999-10-21
标题 :Synthesis of 1,3,5-trisubstituted pyrazoles
发明人：ZHOU JIACHENG; OH LYNETTE MAY; CONFALONE PASQUALE N; LI HUI-YIN; MA PHILIP
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:A novel process for making 1,3,5-trisubstituted pyrazoles of the type shown below from appropriate phenyl hydrazines is described. n These compounds are useful as factor Xa inhibitors.

专利号:US-6306977-B1
优先权日:1998-03-02
标 题 :Mercaptoalkylamide-functionalized resins
发明人：COPPO FRANK TEEN
权利人:DU PONT
摘要:Disclosed are polymers comprising mercaptoalkylamide-functionalized styrene units of Formula Iwhereinm is an integer from 1 to 3;R is H or C1-C3 alkyl; andQ is a bond, -CH2-, -CH2CH2-, -CH2CH2CH2- ora process for their preparation, and their use as supports for solid phase synthesis of small molecules and as supported nucleophiles to aid solution phase synthesis.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).