CAS: 2370-61-8; 2-Amino-3-(2-Hydroxyphenyl)Propanoic Acid

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119660-45-6 7423-92-9 24008-77-3

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Hippuric Acid 3-acetamid°Coumarin N-benzoyl-2-hydroxy-phenylalanineN-benzoyl-2-hydroxy-phenylalanine 3,6-bis-(2-acetoxy-benzylidene)-piperazine-2,5-dionemethyl 2-amino-3-(2-hydroxyphenyl)propanoate (Hydr°Chloride) 2-hydroxy-3,5-diiodo-phenylalanine N-chloroacetyl-2-hydroxy-phenylalanineN-chloroacetyl-2-hydroxy-phenylalanine o-tyramine

N-亚水杨基-3-氨基香豆素置于钯 氢气,苄胺体系中,用 四氢呋喃,溶剂黄146 用作溶剂,化学反应 48.0H,反应生成Dl-O-络氨酸
参考文献:取代香豆素的合成与研究.一种简便的d,L-邻酪氨酸制剂
标题:取代香豆素的合成与研究.一种简便的d,L-邻酪氨酸制剂
摘要:描述了在温和条件下制备氨基香豆素和氨基羟基香豆素的一般程序.通过在碳上含10%钯的情况下用硼氢化钠还原相应的硝基衍生物来制备氨基和乙酰氨基氨基香豆素.(a)在乙醇中的浓盐酸,或(b)1 N的乙酰胺基氨基香豆素的酸水解盐酸在回流下分别得到二氨基香豆素和氨基羟基香豆素.甘氨酸乙酯与水杨醛的缩合得到3-水杨基亚氨基香豆素(xiii),3-氨基香豆素的席夫碱(xii).在上述条件(a)和(b)下酸水解xiii,分别得到xii和3-羟基香豆素(xvi).在二恶烷或二甲基甲酰胺中用10%的钯在木炭上氢化化合物xiii得到3-水杨基氨基香豆素(xvii),而xii,Xiii或xvii在乙酸中用微量水和钯黑氢化则得到氨基酸邻酪氨酸.
Doi:10.1002/jhet.5570230118

专利信息

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:WO-2008098280-A1
优先权日:2007-02-16
标题:Methods for the synthesis of dicarba bridges in growth hormone peptides
发明人：ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
权利人:POLYCHIP PHARMACEUTICALS PTY; UNIV MONASH; ROBINSON ANDREA JANE; VAN LIEROP BIANCA; WHELAN AMANDA
摘要:The invention relates to peptides comprising the carboxy terminal sequence of a growth hormone or an analogue of such a peptide in which the disulfide bridge is replaced by a dicarba bridge. Compositions containing such dicarba bridged peptides and method of treating obesity in an animal such as a human comprising administration of such dicarba bridged peptides are also disclosed.

专利号:US-3915949-A
优先权日:1974-02-12
标题:Solid phase synthesis of ACTH
发明人：COLESCOTT ROBERT L; KAISER EMIL; BOSSINGER CHARLES D; COOK PAUL I
权利人:ARMOUR PHARMA
摘要:Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing R -CH2-Phe-Glu at one end of an amino acid chain, R being the resin and Phe and Glu being the residues of the amino acids phenylalanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides are disclosed which contain amino acid chains identical with the amino acid chains of natural peptides having biological activity. Other resin peptides are disclosed which contain amino acid chains in which the amino acid residues differ in kind and sequence from amino acid chains of natural biologically active peptides but from which peptides having biological activity may be derived.

专利号:US-4301045-A
优先权日:1977-05-02
标 题:Synthesis of peptides
发明人：KAISER EMIL; COLESCOTT ROBERT L
权利人:ARMOUR PHARMA
摘要:Resin peptides useful in the preparation of peptides having biological activity, and particularly such resin peptides containing Pro-Asp-CH2- or Pro-Asn-CH2- at one end of an amino acid chain, being the resin and Pro, Asp and Asn being the residues of the amino acids proline, aspartic acid and asparagine; and processes for the preparation of such resin peptides.

专利号:US-4242238-A
优先权日:1976-02-13
标 题 :Synthesis of peptides
发明人：BOSSINGER CHARLES D; COLESCOTT ROBERT L; KAISER EMIL
权利人:ARMOUR &
摘要:Resin peptides useful in preparing peptides having biological activity, and particularly such resin peptides containing ALA-GLU-CH 2 - R at one end of an amino acid chain, R being the resin and ALA and GLU being the residues of the amino acids alanine and glutamic acid; and processes for the preparation of such resin peptides. Resin peptides including ACTH 1-28 are disclosed which have adrenocorticotropic activity along with processes for their preparation.