专利号:US-7919630-B2 优先权日:2005-09-30 标题 :Synthesis of imidazole 2-thiones via thiohydantoins 发明人:GARST MICHAEL E; DOLBY LLOYD J; ESFANDIARI SHERVIN; AVEY JR ALFRED A; MACKENZIE VIVIAN ROSE; MUCHMORE CHARLES DAVID 权利人:ALLERGAN INC 摘要:The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.
专利号:US-10112955-B2 优先权日:2015-10-29 标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2 发明人:SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH 权利人:EFFECTOR THERAPEUTICS INC 摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
专利号:US-2007203344-A1 优先权日:2005-09-30 标 题 :Synthesis of imidazole 2-thiones via thiohydantoins
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