CAS: 3877-15-4; Methyl Propyl Sulfide

上下游产品

1-thiopropane methylthiol propyl bromide thioureamethyl n-propyl sulfoxide (methylsulfonyl)propane benzyl-methyl-propyl sulfonium ; picrate methyl-(4-nitro-benzyl)-propyl sulfonium ; picrate

烯丙基甲基硫醚置于二(3-甲基丁烷-2-基)硼烷,溶剂黄146体系中,化学反应生成正辛基丙基硫醚
参考文献:用于合成的有机硼烷.1:三烷基硼烷的质子分解.通过硼氢化-质子分解将烯烃方便地非催化转化为饱和化合物
标题:用于合成的有机硼烷.1:三烷基硼烷的质子分解.通过硼氢化-质子分解将烯烃方便地非催化转化为饱和化合物
摘要:对于第一组,三烷基硼烷与羧酸的质子分解进行得非常快,而对于第二组来说,则要慢一些,但是需要升高温度才能除去第三组.仔细检查代表性的对称烃以及混合的三烷基硼烷的质子分解反应,发现连接至硼的烷基的空间要求在该速率中起重要作用.仲烷基比伯烷基更不容易质子水解.受阻更多的烷基仍具有更高的耐受性.由于氢硼化-质子分解序列涉及相对温和的条件,因此该程序可用于氢化包含不稳定基团(例如活性硫,卤素和氮官能团)的烯烃衍生物.质子分解的立体化学已经建立通过降冰片烯的去铁化和产品的去铁化.显然,质子分解在迁移的碳处保持构型而进行.可以将部分烷基化的硼烷用于区域选择性提高的硼氢化-质子水解.所得混合的三烷基硼烷的随后质子分解以非常好的收率提供了所需的烷烃.对热乙酸作用敏感的产品存在困难.例如,当该方法用于由d-柠檬烯制备1-薄荷烯时,产物是外消旋的.
Doi:10.1016/s0040-4020(01)88151-5

专利信息

专利号:US-12157751-B2
优先权日:2021-05-12
标题 :Process for the synthesis of oligomeric siloxane having sulfone moiety, and silicon-containing compounds having sulfone moiety
发明人：SINGHAL PRAVEEN KUMAR; TARAFDAR GOURAV; RAMESH APEKSHA
权利人:MOMENTIVE PERFORMANCE MAT INC
摘要:There is provided herein a process for the synthesis of sulfonyl silanes. There is also provided herein various sulfenylated and sulfonylated silicon-containing compounds made by the process.

专利号:US-9409945-B2
优先权日:1999-10-04
标 题 :Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery
发明人：DESLONGCHAMPS PIERRE; DORY YVES; BERTHIAUME GILLES; OUELLET LUC; LAN RUOXI
权利人:OCERA THERAPEUTICS INC
摘要:A library of macrocyclic compounds of the formula (I) n n n n n n n n n n n n where part (A) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) y — bivalent radical or a covalent bond; n where part (B) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) z — bivalent radical, or a covalent bond; n where part (C) is a n n n n n n n n n n n n n n n n  bivalent radical, a —(CH 2 ) t — bivalent radical, or a covalent bond; and n where part (T) is a —Y-L-Z— radical wherein Y is CH 2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

专利号:US-6172226-B1
优先权日:1993-12-22
标 题:Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
发明人：COULL JAMES M; EGHOLM MICHAEL; HODGE RICHARD P; ISMAIL MOHAMED; RAJUR S B
权利人:PERSEPTIVE BIOSYSTEMS INC
摘要:A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.

专利号:WO-2016090305-A1
优先权日:2014-12-04
标 题:Solid-phase synthesis of peptides containing bulky dehydroamino acids
发明人：CASTLE STEVEN L; JIANG JINTAO; JALAN ANKUR
权利人:CASTLE STEVEN L; JIANG JINTAO; JALAN ANKUR
摘要:Methods of incorporating bulky α,β-dehydroamino acids such as dehydrovaline and dehydroethylnorvaline into peptides via solid-phase peptide synthesis and the resulting peptide compositions is reported. The synthesis method involves using azlactone intermediates for coupling with resin bound peptides.

专利号:US-3978140-A
优先权日:1974-09-23
标题 :Process for the preparation of carbinols
发明人：LANE CLINTON FISHER; MYATT HAL LESLIE
权利人:ALDRICH BORANES INC
摘要:Organic compounds containing a carboxylic acid or carboxylic acid anhydride group are reduced when contacted with an alkali metal borohydride and a boron trihalide in a liquid medium in which diborane is soluble in the form of a labile borane adduct. Hydrolysis of the reaction mixture then provides a useful synthesis of the corresponding carbinols. n The alkali metal borohydride-boron trihalide reagent may either be preformed and reacted subsequently with an organic compound containing a carboxylic acid or anhydride group, or the alkali metal borohydride-boron trihalide reagent may be produced in the presence of an organic compound containing a carboxylic acid or anhydride group. This development makes it possible to synthesize a wide variety of carbinols which are valuable and useful intermediates in organic synthesis.