4-(喹啉-2-基)哌嗪-1-羧酸叔丁酯置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 喹哌嗪 参考文献:Discovery Of Imidazole Carboxamides As Potent And Selective Cck1R Agonists 标题:Discovery Of Imidazole Carboxamides As Potent And Selective Cck1R Agonists 摘要:High-Throughput Screening Revealed Diaryl Pyrazole 3 As A Selective Albeit Modest Cholecystokinin 1 Receptor (Cck1R) Agonist. Sar Studies Led To The Discovery And Optimization Of A Novel Class Of 1,2-Diaryl Imidazole Carboxamides. Compound 44,Which Was Pro. Led Extensively,Showed Good In Vivo Mouse Gallbladder Emptying (Mgbe) And Lean Mouse Overnight Food Intake (Onfi) Reduction Activities. (C) 2008 Elsevier Ltd. All Rights Reserved. DOI:10.1016/j.Bmcl.2008.06.057
专利号:CN-103596927-A 优先权日:2011-06-06 标 题:A new method for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline
专利号:CN-102898428-B 优先权日:2012-09-20 标 题:A kind of microwave synthesis method of spirocyclic piperazine quaternary ammonium salt compound
专利号:US-8076315-B2 优先权日:2005-10-14 标题:Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists 发明人:CARLEY DAVID W; RADULOVACKI MIODRAG 权利人:CARLEY DAVID W; RADULOVACKI MIODRAG; UNIV ILLINOIS 摘要:This invention is directed to methods for preventing or ameliorating sleep-related breathing disorders. The method comprises administration to a patient in need thereof an effective dose of one or a combination of prostanoid receptor antagonists (eg. ramatroban, ifetroban, diphloretin, phosphate, polyphloretin phosphate, seratrodast, SC19220). The prostanoid receptor antagonist or combination of prostanoid receptor antagonists can be administered in conjunction with one or more serotonin receptor agonists, one or more cannabinoids receptor agonists, one or more serotonin reuptake inhibitors, one or more noradrenalin reuptake inhibitors, a combination of reuptake inhibitors, an inhibitor of prostanoid synthesis, or any combination of the foregoing.
专利号:CN-102898428-A 优先权日:2012-09-20 标 题:A kind of microwave synthesis method of spirocyclic piperazine quaternary ammonium salt compound
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合成参考文献
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