CAS: 56974-61-9; Ethyl 4-((6-Guanidinohexanoyl)Oxy)Benzoate Methanesulfonate

上下游产品

CAS号120-47-8 尼泊金乙酯 | CAS号6659-35-4 6-胍基己酸 | CAS号120-47-8 尼泊金乙酯 | CAS号80693-42-1 6-(hydrazinylme...

甲烷磺酸,Gabexate Carbonate 以 丙酮 作为反应溶剂,以77.8 %的收率获得产物甲磺酸加贝酯
参考文献:Cn115141124
标题:Cn115141124

专利信息

专利号:US-11977084-B2
优先权日:2015-02-11
标题 :Nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides
发明人：MARGOLIS SETH S; RAMACHANDRAN KAPIL V
权利人:UNIV JOHNS HOPKINS
摘要:The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or NMP) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. Moreover, the NMP appears to play a highly significant role in aspects of neuronal signaling known to be critical for neuronal function. The inventors have gone on to develop all tools to study this novel mechanisms including protocols and practice for generation and purification of SNAPPs as well as a new and specific inhibitor of the NMP allowing for selective control of this process in the nervous system. The present invention provides methods of making and using these SNAPPs for both laboratory and clinical purposes, the screening for molecules which modulate NMP function in vivo and in vitro, and methods for diagnosis of NMP related diseases.

专利号:WO-2018160662-A1
优先权日:2017-02-28
标题 :A novel nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides
发明人：MARGOLIS SETH; RAMACHANDRAN KAPIL V
权利人:UNIV JOHNS HOPKINS
摘要:The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural membrane bound proteasome (NMP). These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. The present invention provides methods of modulating NMP function, including in cases of NMP associated disease or disorder of neuronal cells, by stimulating or inhibiting NMP function. The present invention also provides methods for stimulation or enhancing cognitive function using SNAPPs, and methods for treating of NMP related diseases using SNAPPs.

专利号:US-2020071367-A1
优先权日:2017-02-28
标 题 :A novel nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides
发明人：MARGOLIS SETH; RAMACHANDRAN KAPIL V
权利人:UNIV JOHNS HOPKINS
摘要:The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural membrane bound proteasome (NMP). These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. The present invention provides methods of modulating NMP function, including in cases of NMP associated disease or disorder of neuronal cells, by stimulating or inhibiting NMP function. The present invention also provides methods for stimulation or enhancing cognitive function using SNAPPs, and methods for treating of NMP related diseases using SNAPPs.