CAS: 5905-69-1; 1-Bromo-4-(Difluoromethoxy)Benzene

上下游产品

4-bromo-phenol Chlorodifluoromethane 2-chloro-2,2-difluoroacetophenone (chlorodifluoromethylsulfonyl)benzene 2-(4-(difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Bis(4-difluoromethoxyphenyl)acetylene 4-(5-((4-(difluoromethoxy)phenyl)ethynyl)-2-fluorophenyl)morpholine 1-difluoromethoxy-4-{3-[3-(2-fluoro-ethyl)-cyclobutyl]phenyl-ethynyl}benzene

4-溴苯酚置于二氟代氙,Potassium Carbonate体系中,用 甲醇,氘代氯仿,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.08H,反应生成 1-溴-4-(二氟甲氧基)苯
参考文献:二氟化氙介导的氟代羧化反应合成二氟和三氟甲氧基芳烃
标题:二氟化氙介导的氟代羧化反应合成二氟和三氟甲氧基芳烃
摘要:在单和二氟芳氧基乙酸衍生物的氟脱羧反应中,Xef 2被证明是比nfsi或selectfluor更有效的氟转移试剂.该方法有效地转化了多种中性和电子贫乏的底物,以非常好至极好的收率提供了所需的二氟和三氟甲基芳基醚.纯化很容易,反应时间少于5分钟,这使得这些氟代脱羧有希望用于未来的pet成像应用.
DOI:10.1021/acs.Orglett.6B02208

专利信息

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:CN-117466744-A
优先权日:2023-11-02
标 题:A method for photochemical iron-catalyzed synthesis of aromatic amine compounds

专利号:WO-2014107380-A1
优先权日:2013-01-01
标 题 :Synthesis of difluoromethyl ethers and sulfides

专利号:WO-2023057548-A1
优先权日:2021-10-07
标题:Ccr6 receptor modulators
发明人：AISSAOUI HAMED; ALLEMANN OLIVER; CAROFF EVA; MEYER EMMANUEL; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:US-8178559-B2
优先权日:2004-12-30
标 题:Organic compounds
发明人：BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI
权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.