CAS: 5933-32-4; 4-Bromobenzohydrazide

上下游产品

CAS号5798-75-4 4-溴苯甲酸乙酯 | CAS号619-42-1 对溴苯甲酸甲酯 | CAS号586-76-5 对溴苯甲酸 | CAS号586-75-4 4-溴苯甲酰氯 | CAS号5798-76-5 Benzoic acid, 4... | CAS号1633-33-6 4-Bromobenzoic ... | CAS号39631-33-9 5-(4-BROMO-PHEN... | CAS号14917-59-0 4-bromobenzoyl azide | CAS号41420-90-0 2-(4-溴苯基)-1,3,4-噁二唑 | CAS号19542-05-3 2,5-双(4-溴苯基)-1,... | CAS号21510-43-0 2-(4-溴苯基)-5-苯基-... | CAS号220843-12-9 2-(4-bromopheny... | CAS号69673-99-0 4-bromo-N-(4-br... | CAS号74038-71-4 1-Acetyl-2-(p-b... | CAS号669715-28-0 1,3,4-OXADIAZOL... | CAS号68047-37-0 2-(4-溴苯基)-5-(1-...

4-溴苯甲酸置于硫酸,一水合肼体系中,化学反应生成 对溴苯甲酰肼
参考文献:基于1,2,4-三唑支架的新型肝x受体调节剂的开发.
标题:基于1,2,4-三唑支架的新型肝x受体调节剂的开发.
摘要:据报道,肝脏x受体(lxr)激动剂可作为动脉粥样硬化,阿尔茨海默氏病和丙型肝炎病毒(hcv)感染的潜在治疗方法.我们已经设计和合成了一系列基于1,2,4-三唑支架的有效化合物,这些化合物是新型的lxr调节剂.在基于细胞的共转染测定中,这些化合物通常起lxr激动剂的作用,我们观测到在效力方面对lxrα(7倍)和lxrβ(7倍)具有选择性的化合物.对所选化合物对hepg2细胞中lxr靶基因表达的影响的评估表明,即使化合物6A-B和8A-B在lxrα和lxrβ共转染测定中是激动剂,其对fasn的表达却起反向激动剂的作用.有趣的是,这些化合物对srebp-1C的表达没有影响,从而证实了独特的lxr调节剂药理学.分子对接研究和计算机模拟adme特性表明,活性化合物具有非常好的结合模式和adme谱.因此,这些化合物可用于具有独特特征的lxr调节剂的体内表征和确定其潜在的临床实用性.
DOI:10.1016/j.Bmcl.2018.12.025

专利信息

专利号:US-2024336559-A1
优先权日:2021-10-06
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; HARANAHALLI KRUPANANDAN; DEL POETA MAURIZIO; GARG ASHNA
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n n n n n n n n n n n n wherein n R 3 , R 4 , R 5 , R 6 , and R 7 are each independently, H, halogen, CN, —CF 3 , —OCF 3 , —NO 2 , alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycle, —OH, —OAc, —OR 13 , —COR 13 , —CH 2 OR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ; n R 9 , R 10 , R 11 , and R 12 are each independently, H, CN, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, —OAc, —COR 13 , —SH, —SR 13 , —SO 2 R 13 , —NH 2 , —NHR 13 , —NR 14 R 15 , —NHCOR 12 , or —CONR 14 R 15 ;n wherein each occurrence of R 13 is independently alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 14 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, wherein each occurrence of R 15 is independently —H, alkyl, alkenyl, alkynyl, aryl, or heteroaryl, n n wherein when R 14 is methyl, R 15 is not methyl; n wherein at least one of R 9 , R 10 , R 11 , and R 12 is not H; n wherein at least one of R 3 , R 4 , R 5 , R 6 , and R 7 is not H.

专利号:US-12325678-B2
优先权日:2017-06-16
标 题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids
发明人：OJIMA IWAO; DEL POETA MAURIZIO; LAZZARINI CRISTINA; HARANAHALLI KRUPANANDAN; SUN YI
权利人:UNIV NEW YORK STATE RES FOUND
摘要:The present invention provides a compound having the structure: n nand use of the compound for inhibiting the growth of or killing.

专利号:US-11858880-B2
优先权日:2017-06-16
标题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids

专利号:US-2022394973-A1
优先权日:2017-06-16
标 题:Anti-fungals compounds targeting the synthesis of fungal sphingolipids

专利号:WO-2018232298-A1
优先权日:2017-06-16
标题:Anti-fungals compounds targeting the synthesis of fungal sphingolipids

专利号:US-11414378-B2
优先权日:2017-06-16
标题 :Anti-fungals compounds targeting the synthesis of fungal sphingolipids