CAS: 59817-32-2; 3-(Piperazin-1-yl)Phenol

上下游产品

CAS号16015-71-7 1-(3-甲氧基苯基)哌嗪 | CAS号507263-18-5 tert-butyl 4-(3... | CAS号2398-37-0 间溴苯甲醚 | CAS号821-48-7 二(2-氯乙基)胺盐酸盐 | CAS号591-27-5 间氨基苯酚 | CAS号198627-86-0 1-B°C-4-(3-羟基苯基)哌嗪 | CAS号824409-50-9 acridin-9-yl-[4... | CAS号919088-08-7 4-[3-(4-methylp...

1-(3-甲氧基苯基)哌嗪置于氢溴酸体系中,化学反应 6.0H,以79%的收率获得产物间羟基苯基哌嗪
参考文献:New .Mu.-Opioid Receptor Agonists With Piperazine Moiety.
标题:New .Mu.-Opioid Receptor Agonists With Piperazine Moiety.
摘要:新μ-阿片受体(mor)激动剂的合成及其对mor的亲和力和激动效力研究.含哌嗪和同哌嗪结构的新型μ-阿片受体(mor)激动剂被合成,并评估了它们对mor的亲和力和激动效力.在合成的化合物中,4-[4-(2-甲氧基苯基)哌嗪-1-基]-N,N-二甲基-2,2-二苯基丁酰胺(20Aa)显示出对在中华仓鼠卵巢(cho)-K1细胞中表达的人类mor的最高亲和力,并且在离体豚鼠回肠制备中对mor具有最高的激动效力.
DOI:10.1248/cpb.49.1314

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