专利号:US-9676783-B2 优先权日:2008-10-22 标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds 发明人:HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN 权利人:ARRAY BIOPHARMA INC 摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.
专利号:US-6465507-B2 优先权日:2000-02-28 标题 :3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors 发明人:TANG PENG CHO; MILLER TODD A; LI XIAOYUAN; ZHANG RUOFEI; CUI JINRONG; HUANG PING; WEI CHUNG CHUN 权利人:SUGEN INC 摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
专利号:US-6207836-B1 优先权日:1993-02-17 标 题 :Indolin-2-one derivatives 发明人:ESAKI TORU; EMURA TAKASHI; HOSHINO EIICHI 权利人:CHUGAI PHARMACEUTICAL CO LTD 摘要:A compound represented by formula (I):wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, -OR5, -SR5 or -NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent -CH2-, -NH- or -O-; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.
专利号:CN-109836365-A 优先权日:2019-01-15 标题 :A class of amine thioacyl fluoride derivatives and synthesis method thereof
专利号:CN-109836365-B 优先权日:2019-01-15 标题 :A class of amine thioacyl fluoride derivatives and synthesis method thereof