CAS: 84371-65-3; Mifepristone

该化合物是一个合成类固醇化合物,主要以其作为堕胎和治疗某些医疗条件如库辛综合症而闻名,具有先质受体抗体抗体作用,阻止对保持妊娠至关重要的progesterone的影响;Mifepristone具有诱发子宫收缩和帮助胚胎与prostaglandin结合使用时被排出的能力的特征;该化合物一般是口服,生物利用率较高;其化学结构包括17-Hyox-11(4-二甲基氨基苯基)-18-oxa-19-noprotrogentones框架,有助于其生物活动;注意到Mifepristone的潜在副作用,包括胃肠扰动,疲劳和荷尔蒙变化;由于对生殖健康的重大影响,mifepristone在许多国家受到严格的监管.

英文名称Mifepristone
中文名称米非司酮
IUPAC名称(8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-6,7,8,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
其它别名11b-[p-(Dimethylamino)phenyl]-17b-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
CAS编号84371-65-3
MFCD编号:MFCD00867226
EINECS号:617-559-7
FDA UNII编号:320T6RNW1F
分子式:C29H35NO2
分子量:429.59
产品CID: 1832226
同类组份化合物CAS109345-60-0 (methochloride)84371-65-3
产品分类原料药 → 激素及调节内分泌功能类药 → 垂体激素类药

相似结构搜索
产品信息参考
InChIKey: VKHAHZOOUSRJNA-GCNJZUOMSA-N
InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数3.0

物理性质

熔点195-198 °C
沸点628.6±55.0 °C at 760 mmHg
闪点334.0±31.5 °C
密度1.2±0.1 g/cm3
PH:D20 +138.5° (c = 0.5 in chloroform)
pKa:12.94±0.60(预测)
PSA:40.54
LogP:4.95
折射率1.623
蒸汽压0.0±1.9 mmHg at 25°C
溶解性Soluble In DMSO (Up To 40 mg/mL) Or In Ethanol (Up To 20 mg/mL).
敏感性按规定使用和贮存的不会分解，避氧化物
外观形态黄色黄色固体
储存条件2-8°C
产品应用为新型抗孕激素,并无孕激素,雌激素,雄激素及抗雌激素活性,能与孕酮受体及糖皮质激素受体结合,对子宫内膜孕酮受体的亲和力比黄体酮强5倍,对受孕动物各期妊娠均有引产效应,可作为非手术性抗早孕药.在有效剂量下对皮质醇水平无明显影响.由于该药不能引发足够的子宫活性,单用于抗早孕时不完全流产率较高,但能增加子宫对前列腺素的敏感性,故加用小剂量前列腺素后既可减少前列腺素的副作用,又可使完全流产率显著提高(达95％以上).本品同时具有软化和扩张子宫颈的作用,故临床除用于抗早孕,催经止孕,胎死宫内引产外,还用于妇科手术
性质描述米非司酮(84371-65-3)的化学性质:熔点150°C.[α]D20+138.5°(C=0.5,氯仿).急性毒性LD50小鼠(g/kg):＞2.6腹腔注射.

MSDS等安全信息

GHS象形图
GHS符号GHS08;
注释: Health hazard
危险类别生殖毒性类别1B
水生慢性毒性类别4
特定目标器官毒性-重复接触类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
警示词Danger(危险)
危险描述H360 |可能损害生育能力或胎儿.
H413 |可能对水生生物造成长期有害影响.
H373 |长期或反复接触可能损害器官.
H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
防范说明P201-P308+P313
UN编号NONH for all modes of transport
危险品标志T
安全声明53-22-36/37/39-45
危险类别码60-61
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号104004-96-8 N-去甲米非司酮

合成工艺路线路线简述

84371-64-2 = 84371-65-3
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C1.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

84371-64-2 = 84371-65-3
反应条件:1.1 Reagents: Acetic Acid Solvents: Water; 2 H,Rt -> 50 °C1.2 Solvents: Water1.3 Reagents: Sodium Hydroxide Solvents: Water; Ph 7
标题:Novel Ru486 (Mifepristone) Analogues With Increased Activity Against Venezuelan Equine Encephalitis Virus But Reduced Progesterone Receptor Antagonistic Activity
作者:Debono,Aaron; Et Al
参考文献:Scientific Reports 日期:2019 卷标:9(1) 页码:1-19]

91934-77-9 = 84371-65-3
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 15 Min,-40 °C1.2 Solvents: Tetrahydrofuran; -40 °C; 15 Min,-40 °C; -40 °C -> Rt; 2 H,Rt1.3 Reagents: Ammonium Chloride Solvents: Water1.4 Reagents: Acetic Acid Solvents: Water; 2 H,Rt -> 50 °C1.5 Solvents: Water1.6 Reagents: Sodium Hydroxide Solvents: Water; Ph 7
标题:Novel Ru486 (Mifepristone) Analogues With Increased Activity Against Venezuelan Equine Encephalitis Virus But Reduced Progesterone Receptor Antagonistic Activity
作者:Debono,Aaron; Et Al
参考文献:Scientific Reports 日期:2019 卷标:9(1) 页码:1-19]

= 84371-65-3
反应条件:1.1 Solvents: Dichloromethane,Water; Ph 7,Rt; Cooled1.2 Reagents: Hydrogen Peroxide Solvents: Hexachloroacetone,Water; 12 H,Rt2.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 - 55 °C; 55 °C -> 0 °C2.2 Catalysts: Cuprous Chloride; 10 - 15 Min,0 °C2.3 Reagents: Estr-9(11)-En-3-One,5,10-Epoxy-17-(1-Propyn-1-Yl)-17-[(Trimethylsilyl)Oxy]-,Cy... Solvents: Tetrahydrofuran; 10 - 15 Min,10 - 15 °C2.4 Reagents: Ammonium Chloride Solvents: Water3.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C3.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

75-77-4 + 84371-69-7 = 84371-65-3
反应条件:1.1 Reagents: Pyridine; 2 H,20 - 24 °C2.1 Solvents: Dichloromethane,Water; Ph 7,Rt; Cooled2.2 Reagents: Hydrogen Peroxide Solvents: Hexachloroacetone,Water; 12 H,Rt3.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 - 55 °C; 55 °C -> 0 °C3.2 Catalysts: Cuprous Chloride; 10 - 15 Min,0 °C3.3 Reagents: Estr-9(11)-En-3-One,5,10-Epoxy-17-(1-Propyn-1-Yl)-17-[(Trimethylsilyl)Oxy]-,Cy... Solvents: Tetrahydrofuran; 10 - 15 Min,10 - 15 °C3.4 Reagents: Ammonium Chloride Solvents: Water4.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C4.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

16053-58-0 + 2366140-35-2 = 84371-65-3 + 104004-96-8
反应条件:1.1 Solvents: Ethanol,Water; Ph 7.2
标题:Photorearrangement Of Quinoline-Protected Dialkylanilines And The Photorelease Of Aniline-Containing Biological Effectors
作者:Deodato,Davide; Et Al
参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(11) 页码:7342-7353]

2361320-85-4 = 84371-65-3 + 104004-96-8
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; 0 °C; 12 H,Rt2.1 Solvents: Acetonitrile; 5 H,Reflux2.2 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 5 H,Rt3.1 Solvents: Ethanol,Water; Ph 7.2
标题:Photorearrangement Of Quinoline-Protected Dialkylanilines And The Photorelease Of Aniline-Containing Biological Effectors
作者:Deodato,Davide; Et Al
参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(11) 页码:7342-7353]

= 84371-65-3
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C1.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

586-77-6 = 84371-65-3
反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 - 55 °C; 55 °C -> 0 °C1.2 Catalysts: Cuprous Chloride; 10 - 15 Min,0 °C1.3 Reagents: Estr-9(11)-En-3-One,5,10-Epoxy-17-(1-Propyn-1-Yl)-17-[(Trimethylsilyl)Oxy]-,Cy... Solvents: Tetrahydrofuran; 10 - 15 Min,10 - 15 °C1.4 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C2.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

586-77-6 + 84371-57-3 + 162681-70-1 = 84371-65-3
反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 - 55 °C; 55 °C -> 0 °C1.2 Catalysts: Cuprous Chloride; 10 - 15 Min,0 °C1.3 Solvents: Tetrahydrofuran; 10 - 15 Min,10 - 15 °C1.4 Reagents: Ammonium Chloride Solvents: Water2.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C2.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

586-77-6 + 39931-87-8 + 39931-88-9 = 84371-65-3
反应条件:1.1 Reagents: Magnesium,Iodine Solvents: Tetrahydrofuran; 1 H,50 °C; 50 °C -> Rt1.2 Solvents: Tetrahydrofuran; 50 °C; 1 H,50 °C1.3 Catalysts: Cuprous Chloride Solvents: Tetrahydrofuran; 30 Min,0 °C; 1 H,0 °C; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 15 Min,-40 °C2.2 Solvents: Tetrahydrofuran; -40 °C; 15 Min,-40 °C; -40 °C -> Rt; 2 H,Rt2.3 Reagents: Ammonium Chloride Solvents: Water2.4 Reagents: Acetic Acid Solvents: Water; 2 H,Rt -> 50 °C2.5 Solvents: Water2.6 Reagents: Sodium Hydroxide Solvents: Water; Ph 7
标题:Novel Ru486 (Mifepristone) Analogues With Increased Activity Against Venezuelan Equine Encephalitis Virus But Reduced Progesterone Receptor Antagonistic Activity
作者:Debono,Aaron; Et Al
参考文献:Scientific Reports 日期:2019 卷标:9(1) 页码:1-19]

5571-36-8 = 84371-65-3
反应条件:1.1 Reagents: Hexafluoroacetone,Hydrogen Peroxide Solvents: Dichloromethane; 45 Min,-5 °C1.2 Solvents: Dichloromethane; -5 °C1.3 Reagents: Trisodium Phosphate; 8 H,0 °C2.1 Reagents: Magnesium,Iodine Solvents: Tetrahydrofuran; 1 H,50 °C; 50 °C -> Rt2.2 Solvents: Tetrahydrofuran; 50 °C; 1 H,50 °C2.3 Catalysts: Cuprous Chloride Solvents: Tetrahydrofuran; 30 Min,0 °C; 1 H,0 °C; 0 °C -> Rt; Overnight,Rt3.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; 15 Min,-40 °C3.2 Solvents: Tetrahydrofuran; -40 °C; 15 Min,-40 °C; -40 °C -> Rt; 2 H,Rt3.3 Reagents: Ammonium Chloride Solvents: Water3.4 Reagents: Acetic Acid Solvents: Water; 2 H,Rt -> 50 °C3.5 Solvents: Water3.6 Reagents: Sodium Hydroxide Solvents: Water; Ph 7
标题:Novel Ru486 (Mifepristone) Analogues With Increased Activity Against Venezuelan Equine Encephalitis Virus But Reduced Progesterone Receptor Antagonistic Activity
作者:Debono,Aaron; Et Al
参考文献:Scientific Reports 日期:2019 卷标:9(1) 页码:1-19]

84371-69-7 = 84371-65-3
反应条件:1.1 Solvents: Dichloromethane,Water; Ph 7,Rt; Cooled1.2 Reagents: Hydrogen Peroxide Solvents: Hexachloroacetone,Water; 12 H,Rt2.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 - 55 °C; 55 °C -> 0 °C2.2 Catalysts: Cuprous Chloride; 10 - 15 Min,0 °C2.3 Solvents: Tetrahydrofuran; 10 - 15 Min,10 - 15 °C2.4 Reagents: Ammonium Chloride Solvents: Water3.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C3.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

5571-36-8 = 84371-65-3
反应条件:1.1 Reagents: Ethylmagnesium Bromide Solvents: Tetrahydrofuran; 1.5 - 2 H,28 - 32 °C1.2 Solvents: Tetrahydrofuran; 20 Min,Rt2.1 Solvents: Dichloromethane,Water; Ph 7,Rt; Cooled2.2 Reagents: Hydrogen Peroxide Solvents: Hexachloroacetone,Water; 12 H,Rt3.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 45 - 55 °C; 55 °C -> 0 °C3.2 Catalysts: Cuprous Chloride; 10 - 15 Min,0 °C3.3 Solvents: Tetrahydrofuran; 10 - 15 Min,10 - 15 °C3.4 Reagents: Ammonium Chloride Solvents: Water4.1 Reagents: Sulfuric Acid Solvents: Methyl Ethyl Ketone,Water; 30 Min,Rt; Rt -> 0 °C4.2 Reagents: Ammonia Solvents: Water; Ph 8,0 °C
标题:Method For Obtaining 17β-Hydroxy-11β-[4-(Dimethylamino)Phenyl]-17α-(Prop-1-Ynyl)Estra-4,9-Dien-3-One
参考文献:Eurasian Patent Organization]

84371-65-3 + 2361317-72-6 = 84371-65-3 + 104004-96-8
反应条件:1.1 Solvents: Acetonitrile; 5 H,Reflux1.2 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 5 H,Rt2.1 Solvents: Ethanol,Water; Ph 7.2
标题:Photorearrangement Of Quinoline-Protected Dialkylanilines And The Photorelease Of Aniline-Containing Biological Effectors
作者:Deodato,Davide; Et Al
参考文献:Journal Of Organic Chemistry 日期:2019 卷标:84(11) 页码:7342-7353

(8S,11R,13S,14S,17S)-11-[4-(Dimethylamino)Phenyl]-13-Methyl-17-Prop-1-Ynylspiro[1,2,6,7,8,11,12,14,15,16-Decahydrocyclopenta[a]Phenanthrene-3,2'-1,3-Dioxolane]-17-Ol 反应生成米非司酮
参考文献:Teutsch,J. G.;Torelli,V.;Deraedt,R.;Philibert,D.
标题:Teutsch,J. G.;Torelli,V.;Deraedt,R.;Philibert,D.

海关参考信息

2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
2901292000-乙炔
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2025049961-A1
优先权日:2021-12-23
标题 :Scalable and high-purity cell-free synthesis of closed-ended dna vectors
发明人：MONDS RUSSELL; CIPI JORIS; BLACKSTOCK DANIEL JASON; DURANT JOHN CHESTER
权利人:GENERATION BIO CO
摘要:This disclosure provides methods for scalable and high-purity cell-free synthesis of DNA vectors, particularly closed-ended DNA vectors (e.g., ceDNA vectors) having linear and continuous structure for delivery and expression of a transgene. The cell-free synthesis includes digesting a double-stranded DNA construct with at least one restriction endonuclease that is capable of cleaving the construct at cleavage sites, which are distinct from the recognition sites, to release an insert having unique overhangs that regulate the high specificity of the subsequent ligation reaction. The insert is then ligated with inverted terminal repeat (ITR) oligonucleotides to form the closed-ended DNA vector. Corresponding DNA vectors prepared by these methods and related products as well other base and intermediate vectors and constructs associated with the methods are also provided in this disclosure.

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-8183402-B2
优先权日:2007-06-27
标题:Industrial method for the synthesis of 17-acetoxy-11Î²[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process
发明人：BODI JOZSEF; VISKY GYOERGY; SZELES JANOS; MAHO SANDOR; SANTA CSABA; CSOERGEI JANOS; TUBA ZOLTAN; TERDY LASZLO; MOLNAR CSABA; ARANYI ANTAL; HORVATH ZOLTAN; BALOGH GABOR
权利人:BODI JOZSEF; VISKY GYOERGY; SZELES JANOS; MAHO SANDOR; SANTA CSABA; CSOERGEI JANOS; TUBA ZOLTAN; TERDY LASZLO; MOLNAR CSABA; ARANYI ANTAL; HORVATH ZOLTAN; BALOGH GABOR; RICHTER GEDEON NYRT
摘要:The present invention relates to a process for the synthesis of the 17-acetoxy-11Î²-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): n nfrom 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):

专利号:WO-2017100796-A1
优先权日:2015-12-11
标题 :Modulation of globoseries glycosphingolipid synthesis and cancer biomarkers
发明人：WONG CHI-HUEY; HSU TSUI-LING; WU CHUNG-YI; CHEUNG SARAH K C; CHUANG PO-KAI
权利人:SINACA ACAD; WONG CHI-HUEY; HSU TSUI-LING
摘要:The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta- 4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for disgnostic and therapeutic uses.

专利号:US-9662347-B2
优先权日:2010-05-11
标题 :Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system
发明人：LEE BONG HEE; BYUN KYUNG HEE
权利人:LEE BONG HEE; BYUN KYUNG HEE; GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND
摘要:The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death. Therefore, the AGE-albumin synthesis inhibitor of the present invention can be valuably used in the diagnosis or treatment of degenerative diseases or autoimmune diseases such as Alzheimer's disease, strokes, Parkinson's disease, amyotrophic lateral sclerosis, rheumatoid arthritis, diabetic retinopathy, AIDS, aging, pulmonary fibrosis, spinal cord injuries, etc.

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